research papers
Peptidoglycan O-acetylesterase (Ape1), which is required for host survival in Neisseria sp., belongs to the diverse SGNH hydrolase superfamily, which includes important viral and bacterial virulence factors. Here, multi-domain crystal structures of Ape1 with an SGNH catalytic domain and a newly identified putative peptidoglycan-detection module are reported.
research papers
Arylamine N-acetyltransferases (NAT) are xenobiotic metabolizing-enzymes that can acetylate aromatic amine antibiotics. The structure of NAT from the pathogen Mycobacterium abscessus is reported and shows differences with other mycobacterial isoforms.