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Crystal structures of two truncated variants of the transcription factor PpsR from R. sphaeroides are presented that enabled the phasing of a triple PAS domain construct. Together, these structures reveal the importance of α-helical PAS extensions for multi-PAS domain-mediated protein oligomerization and function.
Keywords: Per–ARNT–Sim; N-cap; flanking region; AppA; coiled coil; linker; signalling helix; PAS dimer.
