research papers
The crystal structure of AGME from Burkholderia thailandensis resistant to acid-induced denaturation revealed a decameric form. The in silico docking study of this enzyme with ADP-D,D-Hep supports a one-base mechanism as a major catalytic pathway.
research papers
The analyses of the crystal structure of Nm23-H1 combined with H/D exchange experiments under oxidative condition revealed an intramolecular disulfide bond triggering a large conformational change that destabilizes the hexameric state and provides an environment for the oxidation of Cys109 to sulfonic acid.