Structure and in silico substrate-binding mode of ADP-L-glycero-D-manno-heptose 6-epimerase from Burkholderia thailandensis

The crystal structure of AGME from Burkholderia thailandensis resistant to acid-induced denaturation revealed a decameric form. The in silico docking study of this enzyme with ADP-D,D-Hep supports a one-base mechanism as a major catalytic pathway.

High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26

This study presents crystal structures of the catalytic domain of human DUSP26 and a catalytically inactive mutant at 1.67 and 2.20 Å resolution, respectively.