Structure and in silico substrate-binding mode of ADP-L-glycero-D-manno-heptose 6-epimerase from Burkholderia thailandensis

The crystal structure of AGME from Burkholderia thailandensis resistant to acid-induced denaturation revealed a decameric form. The in silico docking study of this enzyme with ADP-D,D-Hep supports a one-base mechanism as a major catalytic pathway.