The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer

Fam96a is a mammalian DUF59 protein, but its structure diverges from those of bacterial DUF59 proteins. Structural clues suggest similarities between Fam96a and amyloidogenic proteins.

Structural basis of nuclear import of flap endonuclease 1 (FEN1)

The crystal structure of the complex between the nuclear transport factor importin-α and the peptide corresponding to the nuclear localization sequence from flap 1 endonuclease (FEN1) has been determined. The structure rectifies the binding mode previously proposed and therefore explains the functional results that were previously controversial.