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The title compound, C27H28N2O, is a lophine (2,4,5-triphenyl-1H-imidazole) derivative with an n-pentyl chain on the amine N atom and a 4-methoxy substituent on the benzene ring. The two phenyl and methoxybenzene rings are inclined to the imidazole ring at angles of 25.32 (7), 76.79 (5) and 35.42 (7)°, respectively, while the methoxy substituent lies close to the plane of its benzene ring, with a maximum deviation of 0.126 (3) Å for the methoxy C atom. In the crystal, inversion dimers linked by pairs of C—HO hydrogen bonds generate R22(22) loops. These dimers are stacked along the a-axis direction.
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In the title compound, C21H21BrClNO4, the dihydropyridine ring adopts a flattened boat conformation. The 3-bromo-5-chloro-2-hydroxyphenyl ring forms a dihedral angles of 84.44 (7)° with the dihydropyridine mean plane. The molecular conformation is stabilized by an intramolecular O—HO hydrogen bond, with an S(8) ring motif. In the crystal, O—HO and C—HO hydrogen bonds link the molecules, forming a three-dimensional network.
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In the title compound, C19H17NO2, the dihedral angle between the benzene ring and the naphthalene ring system is 9.72 (5)°, while the torsion angle of the C—N—C—C bridging group is 179.24 (17)°. The methyl group of the 1-phenylethanol moiety is disordered over two positions with a refined occupancy ratio of 0.775 (5):0.225 (5). The molecular conformation is stabilized by an intramolecular N—HO hydrogen bond, which generates an S(6) ring motif. In the crystal, molecules are linked by O—HO hydrogen bonds, forming zigzag chains propagating along the c-axis direction. Neighbouring chains are linked via C—HO interactions, forming a two-dimensional slab-like network parallel to the bc plane.
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The molecular conformation of the title compound, C13H8BrFN2O3, is essentially planar, with maximum deviations of 0.076 (1) and −0.080 (2) Å for the O atoms of the NO2 group. The molecular conformation is stabilized by an intramolecular O—HN hydrogen bond, forming an S(6) ring motif. In the crystal, pairs of molecules are linked via two pairs of C—HO hydrogen bonds, forming inversion dimers that enclose R22(7)R22(10)R22(7) ring motifs.
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In the title molecule, C14H15NO3, the ring system is essentially planar, with an r.m.s. deviation of 0.003 Å. The atoms of the ethane-1,2-diol group were refined as disordered over two sets of sites in a ratio of 0.815 (3):0.185 (3). The molecular conformation is stabilized in part by an intramolecular N—HO hydrogen bond, which forms an S(6) ring. In the crystal, molecules are connected by N—HO and O—HO hydrogen bonds, forming a two-dimensional network parallel to (100). The network also features weak C—HO hydrogen bonds. Weak C—Hπ interactions also observed.
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The title compound, C26H25N3, crystallizes with four independent molecules, 1–4, in the asymmetric unit of the triclinic unit cell. The allyl substituents on the imidazole rings adopt similar conformations in all four molecules. The imadazole and the 4-and 5-substituted phenyl rings of two pairs of molecules in the asymmetric unit stack parallel to (110). In contrast, the dimethylaniline systems in these pairs of molecules are almost normal to one another, with dihedral angles of 85.84 (10) and 85.65 (10)° between the benzene rings of the two dimethylaniline fragments of molecules 1 and 2, and 3 and 4, respectively. The crystal structure features an extensive series of C—Hπ interactions that link the molecules into undulating rows along the c axis. The crystal studied was a pseudo-merohedral twin with twin law [-100, 0-10, 111] and the BASF parameter refined to 0.513 (3).
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In the xanthene ring system in the title compound, C19H18O4, the 4H-pyran ring has a maximum deviation of 0.110 (2) Å from planarity and the cyclohexene ring exhibits a puckered conformation [puckering parameters QT = 0.452 (3) Å, θ = 57.0 (4) and φ = 131.7 (4)°]. The cyclohexene ring attached to the xanthene system adopts an envelope conformation, with the middle of the three methylene C atoms as the flap atom. In the crystal, O—HO and C—HO hydrogen bonds form infinite chains of R12(6) ring motifs along [100] with the xanthene groups arranged in an alternating zigzag manner.
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In the title compound, C19H16BrClO4, both the fused xanthene rings and one of the cyclohexane rings adopt envelope conformations, while the other cyclohexane ring is in a chair conformation. In the crystal, molecules are linked by C—HO hydrogen bonds, forming infinite chains running along [10-1] incorporating R22(16) ring motifs. In addition, C—Hπ interactions and weak π–π stacking interactions [centroid–centroid distance = 3.768 (3) Å] help to consolidate the packing.
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The title compound, C26H24Cl2N2, crystallizes with two independent molecules (1 and 2) in the asymmetric unit. In molecule 1, the two phenyl and 2,6-dichlorophenyl rings are inclined to the imidazole ring at angles of 74.12 (14), 26.13 (14) and 67.30 (14)°, respectively. In molecule 2, due to the different molecular environment in the crystal, the corresponding angles are different, viz. 71.72 (15), 16.14 (15) and 80.41 (15)°, respectively. In the crystal, molecules 1 and 2 are linked by C—HCl interactions, and inversion-related 2 molecules are linked by C—Hπ interactions. There are no other significant intermolecular interactions present.
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The title molecule, C17H11FN2O3, is nearly planar [maximum deviation = 0.197 (1) Å] and the molecular conformation is stabilized by an N—HO hydrogen bond forming an S(6) ring motif. The H atom of the intramolecular hydrogen bond was found to be disordered over two sites and thus both the hydroxy and keto tautomers are simultaneously present in the solid. Refinement of the occupancy of this site suggests that the hydroxy form is the major component [occupancy refined to 0.59 (3):0.41 (3)]. Bond lengths are also largely consistent with dominance of the hydroxy form. In the crystal, molecules are linked by C—HO hydrogen bonds, forming layers parallel to (101). π–π stacking interactions [centroid–centroid distances = 3.5649 (9) and 3.7579 (9) Å] inter-connect these layers.
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In the title compound, C26H24N2O2, the two phenyl and the 2,5-dimethoxyphenyl rings are inclined to the imidazole ring at dihedral angles of 30.38 (8), 56.59 (9) and 73.11 (9)°, respectively. In the crystal, molecules are linked by pairs of C—HO interactions into centrosymmetric dimers with graph-set notation R22(8). C—Hπ interactions are also observed.
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The title compound, C25H20N2O2, crystallized with two molecules in the asymmetric unit, in one of which the atoms of the terminal propenyl group are disordered over two sets of sites, with a refined occupancy ratio of 0.870 (4):0.130 (4). The central imidazole ring makes dihedral angles of 25.51 (11), 40.73 (11) and 27.36 (11)° with the three pendant rings in one molecule and 22.56 (10), 60.72 (10) and 5.85 (10)° in the other. In the crystal, molecules are linked by N—HN and C—HO hydrogen bonds, forming a three-dimensional network. The crystal structure also features C—Hπ interactions and π–π stacking [centroid–centroid distances = 3.8834 (18) and 3.9621 (17) Å] interactions.
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In the title compound, C26H25ClN2, the phenyl rings and the 2-(4-chlorophenyl) group make dihedral angles of 30.03 (11), 67.49 (12) and 41.56 (11)°, respectively, with the imidazole ring. In the crystal, the molecules interact with each other via very weak C—Hπ contacts, forming layers parallel to (110).
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In the xanthenone system of the title compound, C23H20O4, the pyran ring has a maximum deviation of 0.111 (1) Å from planarity and the outer cyclohexene ring exhibits a puckered conformation. The three methylene C atoms of the cyclohexene ring bonded to the pyran unit are disordered over two sets of sites [occupancies = 0.570 (3) and 0.430 (3)]. In the crystal, molecules are linked by C—HO and O—HO hydrogen bonds, forming a two-dimensional network parallel to (110). A C—Hπ interaction occurs between these networks.