4-(4-Fluoro­phen­yl)-1-phenyl-3-(pyridin-4-yl)-1H-pyrazol-5-amine

In the title compound, C₂₀H₁₅FN₄, the pyrazole ring forms dihedral angles of 43.51 (6), 39.95 (6) and 32.23 (6)° with the directly attached 4-fluoro­phenyl, pyridine and phenyl rings, respectively. The crystal packing is stabilized by inter­molecular N—H...N and N—H...F hydrogen bonds.

4-(4-Fluoro­phen­yl)-1-(4-nitro­phen­yl)-3-(pyridin-4-yl)-1H-pyrazol-5-amine

In the crystal structure of the title compound, C₂₀H₁₄FN₅O₂, the pyrazole ring forms dihedral angles of 59.3 (2), 25.6 (2) and 46.0 (2)° with the directly attached 4-fluoro­phenyl, pyridine and nitro­phenyl rings, respectively. The crystal packing is characterized by inter­molecular N—H...N and N—H...O hydrogen bonds.

Ethyl 5-amino-3-(pyridin-4-yl)-1-(2,4,6-tri­chloro­phen­yl)-1H-pyrazole-4-carb­oxyl­ate dimethyl sulfoxide hemisolvate

The asymmetric unit of the title compound, C₁₇H₁₃Cl₃N₄O₂·0.5C₂H₆OS, contains two almost identical mol­ecules and one dimethyl sulfoxide (DMSO-d₆) solvent mol­ecule. The pyrazole ring forms dihedral angles of 54.6 (4) and 80.0 (4)° in one mol­ecule, and dihedral angles of 54.2 (4) and 81.2 (4)° in the other mol­ecule, with the directly attached pyridine and trichloro­phenyl rings, respectively. The dihedral angles of the pyridine and trichloro­phenyl rings are 51.2 (4) and 52.0 (4)°, respectively. The crystal packing is characterized by intra- and inter­molecular hydrogen bonds. The crystal is a nonmerohedral twin with a contribution of 0.488 (1) for the minor twin component. The terminal ethyl group of one mol­ecule and the S atom of DMSO are disordered over two sites.

4-[5-Amino-4-(4-fluoro­phen­yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl]benzo­nitrile

In the crystal structure of the title compound, C₂₁H₁₄FN₅, the pyrazole ring forms dihedral angles of 38.0 (1), 40.0 (1) and 28.5 (1)° with the directly attached 4-fluoro­phenyl, pyridine and benzonitrile rings, respectively. The crystal packing is characterized by N—H...N hydrogen bonds, which result in a two-dimensional network parallel to the ac-plane.

4-(4-Fluoro­phen­yl)-3-(pyridin-4-yl)-1-(2,4,6-trichloro­phen­yl)-1H-pyrazol-5-amine

In the title compound, C₂₀H₁₂Cl₃FN₄, the pyrazole ring forms dihedral angles of 47.51 (9), 47.37 (9) and 74.37 (9)° with the directly attached 4-fluoro­phenyl, pyridine and 2,4,6-trichloro­phenyl rings, respectively. Only one of the two amino H atoms is involved in hydrogen bonding. The crystal packing is characterized by N—H...N hydrogen bonds, which result in infinite chains parallel to the c axis.

N-[(3RS,4SR)-1-Benzyl-4-methyl­piperi­din-3-yl]-1-(4-methylphenyl­sulfonyl)-5-nitro-1H-pyrrolo­[2,3-b]pyridin-4-amine

The structure of the title compound, C₂₇H₂₉N₅O₄S, displays an intra­molecular N—H...O hydrogen bond. The pyrrolo­[2,3-b]pyridine core makes a dihedral angle of 85.5 (4)° with the benzyl residue and a dihedral angle of 89.4 (9)° with the tosyl ring. The nitro group is slightly twisted out of the plane of the planar pyrrolo­pyridine system [(—N—)C—C—N—O torsion angle = −4.61 (18)° and (—NH—)C—C—N—O = −6.46 (18)°].

N-[(3RS,4RS)-1-Benzyl-4-methyl­piperidin-3-yl]-5-nitro-1-phenyl­sulfonyl-1H-pyrrolo­[2,3-b]pyridine-4-amine

The pyrrolo­pyridine system in the title compound, C₂₇H₂₉N₅O₄S, is oriented at a dihedral angle of 71.20 (5)° towards the phenyl ring of the tosyl residue and at a dihedral angle of 45.43 (4)° towards the benzyl group. The structure shows an intra­molecular N—H...O and a weak intra­molecular N—H...N hydrogen bond. The piperidine ring adopts a chair conformation, with the cis substituents displaying a torsion angle of −54.59 (18)°.

1-[(3RS,4RS)-1-Benzyl-4-methyl­piperi­din-3-yl]-1,6-dihydro­imidazo[4,5-d]pyrrolo­[2,3-b]pyridine hemihydrate

The benzyl residue in the title compound, C₂₁H₂₃N₅·0.5H₂O, is oriented at a dihedral angle of 83.8 (3)° towards the 1,6-dihydro­imidazo[4,5-d]pyrrolo­[2,3-b]pyridine system. The piperidine ring adopts a chair conformation with the cis substituents displaying a torsion angle of -45.91 (16)°. In the crystal, mol­ecules are accumulated as racemic dimers by two inter­molecular hydrogen bonds between the pyrrolo­pyridine systems. Another hydrogen bond is formed between the imidazole ring and the cocrystallized water mol­ecule, which is located on a twofold rotation axis.

2-[5-Bromo-1-(3-chloro­benz­yl)-2-methyl-1H-indol-3-yl]acetic acid

In the title compound, C₁₈H₁₅BrClNO₂, the indole ring system forms a dihedral angle of 86.9 (2)° with the 3-chloro­benzyl ring. In the crystal, mol­ecules form inversion dimers connected via pairs of O—H...O hydrogen bonds.

3-(4-Bromo­phen­yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The asymmetric unit of the title compound, C₁₆H₁₁BrN₂O, contains two independent mol­ecules with slightly different geometries. The 4-bromo­benzene ring forms dihedral angles of 26.0 (2) and 39.9 (7)° with the pyrazole ring in the two mol­ecules while the phenyl ring is oriented at 19.7 (5) and 7.3 (0)° with respect to the pyrazole ring.