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In the title compound, C11H11F3N2O, a urea derivative, the best plane through the pyrrole ring makes a dihedral angle of 9.69 (13)° with the benzene ring. The amino H atom is shielded, so that it is not involved in any hydrogen-bonding inter­actions.

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The title mol­ecule, C15H20O4, has an E conformation about its C=C bond and is almost planar (r.m.s. deviation of all non-H atoms = 0.04 Å). The crystal structurere features O—H...O and C—H...O hydrogen bonds.

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The title compound, C12H14BrN3O, is built up from two fused six-membered rings and one six-membered ring linked through a spiro C atom. The hydro­pyrimidine ring has an envelope conformation and the cyclo­hexane ring is in a chair conformation. In the crystal, mol­ecules are linked by N—H...O and N—H...N hydrogen bonds, forming a mol­ecular tape along the b axis.

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The title compound, C40H32N2, has crystallographic twofold rotation symmetry, with two C atoms lying on the axis. The dihedral angle between the two benzene rings of the 4-phenyl-2,6-dimethyl­phenyl group is 35.74 (17)°. The acenaphthene ring makes an angle of 76.93 (11)° with the benzene ring bonded to the N atom and an angle of 41.53 (13)° with the other benzene ring.

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In the title compound, [Zn(C7H4ClO2)2(C10H8N2)], the ZnII atom is coordinated by two O atoms from two 4-chloro­benzoate ligands and two N atoms from a chelating 2,2′-bipyridine (bpy) mol­ecule in a distorted N2O2 tetra­hedral geometry. The ZnII atom is located on a twofold rotation axis, which also passes through the mid-point of the central C—C bond of the bpy ligand. In the crystal, weak C—H...O hydrogen bonds and π–π stacking inter­actions between the pyridine rings of the bpy ligands [centroid–centroid distance = 3.642 (3) Å] link the complex mol­ecules into a two-dimensional supra­molecular structure parallel to (100). An intra­molecular C—H...O hydrogen bond is also observed.

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The mononuclear NiII amide, [Ni(C12H21N2Si)2], has the NiII atom N,N′-chelated by the N-silylated anilinide ligands. The ligands are arranged cis to each other and obey the C2-symmetry operation. The two ends of the N—Si—N chelating unit exhibit different affinities for the metal atom: the Ni—Nanilinide bond length is 1.913 (3) Å and Ni—Namine is 2.187 (3) Å. The four-coordinate NiII ion demonstrates a distorted tetra­hedral geometry.

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The title compound, C21H26NO4+·Br, also known as R-methyl­naltrexone (MNTX) bromide, is a selective peripher­ally acting μ-opioid receptor antagonist with a oroxymorphone skeleton, synthesized by hydroxyl protection, N-methyl­ation, deprotection and anion exchange of naltrexone. It comprises a five-ring system A/B/C/D/E. Rings C and E adopt distorted chair conformations, whereas ring D is in half-chair conformation. The C/E ring junctions are trans fused. The dihedral angle between rings D and E is 82.3 (1)°, while the dihedral angles between the planes of rings C and A, and rings D and E are respectively 81.7 (1), 75.9 (1) and 12.2 (1)°. In the crystal, mol­ecules are linked by O—H...Br hydrogen bonds.

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The dihedral angle between the planes of the two aromatic rings of the title compound, C16H13N3S, is 56.7 (3)°. The crystal packing is stabilized by inter­molecular N—H...N hydrogen bonds, which link the mol­ecules into chains along [11\overline{1}].

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The title complex, [Ag2(C25H22P2)2(C9H7N)2](CF3SO3)2·C9H7N, was prepared by the reaction of silver(I) trifluoro­methane­sulfonate with isoquinoline and bis­(diphenyl­phosphan­yl)methane (dppm). The dinuclear mol­ecule is located about a center of inversion and the AgI atom is coordinated by two dppm P atoms and one isoquinoline N atom, forming an eight-membered metalla ring. In addition, in the asymmetric unit, there is a half-mol­ecule of isoquinoline located about a center of inversion. Since this mol­ecule does not possess this symmetry, for one position in the ring there is superposition of both a C atom of a C—H group and the isoquinoline N atom. In the structure, the Ag—P distances [2.4296 (9) and 2.4368 (9) Å] agree with the corresponding distances in related structures, while the Ag—N bond length [2.489 (3) Å] is slightly longer than that in related structures. On the other hand, the P—Ag—P angle [156.44 (3)°] is much larger than the corresponding angles in related structures. The trifluoro­methane­sulfonate anions do not coordinate to AgI atoms. As is usually found for these anions, the –CF3 group is disordered over two orientations [occupancies = 0.57 (12) and 0.43 (12)].

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In the title one-dimensional coordination polymer, [Mn(NCS)3(C10H16N3)]n, the MnII atom is coordinated by an N,N′-bidentate Schiff base and four thio­cyanate ligands in a distorted octa­hedral N5S geometry. Bridging thio­cyanate ligands inter­connect adjacent [Mn(NCS)2(C10H16N3)] units, giving rise to helical chains extending along the b axis. The chains are further linked through N—H...S hydrogen bonds, leading to a three-dimensional supra­molecular network.

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In the asymmetric unit of the title compound, [Ag(C10H6N4)2(CF3CO2)], there two mononuclear but slightly different complex units. In each, two κ2N:N-chelating 5-(pyridin-2-yl)pyrazine-2-carbonitrile ligands surround the AgI atom, giving an N4O square-pyramidal coordination geometry with one trifluoro­acetate O atom at the apex. The difference between the two lies in the Ag—N bond lengths: in one complex, three normal [range 2.272 (5)–2.552 (5) Å] and one long [2.706 (4) Å] and in the second, two normal [2.254 (5) and 2.290 (5) Å] and two long [2.647 (5) and 2.675 (5) Å] are present. Short inter­molecular F...F contacts [2.586 (4) Å] and weak π–π stacking inter­actions [minimum ring centroid separation 3.836 (5) Å] between pyridyl and pyrazinyl rings connect the complex units, forming columns which extend along the b-axis direction.

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The supra­molecular structure of the title compound, C9H11N3O3S2, is defined by two inter­molecular hydrogen bonds. Pairs of N—H...N hydrogen bonds link the mol­ecules into centrosymmetric dimers and N—H...O hydrogen bonds link the dimers into a tubular chain structure running parallel to the a axis.

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The title compound, C14H15BrN2O2, an inter­mediate in drug discovery, was synthesized by the reaction of 5-bromo­pyridin-2-amine and 3,4-dimeth­oxy­benzaldehyde. In the crystal, molecules are linked via pairs ofN—H...N hydrogen bonds, leading to the formation of inversion dimers. A short contact occurs between the aryl H atom (ortho position from N) and the centroid of the benzene ring.

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In the title complex, {[Ni2(C14H4N2O8)(H2O)6]·2H2O}n, the two NiII atoms are located in different special positions (one on a twofold rotation axis and the second on a centre of symmetry) and have different distorted octa­hedral environments (one by two N atoms from a bipyridine unit, two O atoms from two water mol­ecules and two O atoms from two carboxyl­ate groups, and the second by four O atoms from four water mol­ecules and two O atoms from two carboxyl­ate groups). Thus, the environments of the NiII atoms may be denoted as NiN2O4 and NiO6. In the crystal, there exists an extensive network of classical O—H...O hydrogen bonds.

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The title compound, C20H16N6, is centrosymmetric with the mid-point of the N—N bond located on an inversion center. The imidazole ring is oriented at a dihedral angle of 28.03 (6)° with respect to the attached benzene ring. In the crystal, molecules are linked via C—H...N interactions.

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In the title compound, C16H11N3O, the dihedral angles between the 3-cyano­benzene and benzene planes and the 1H-pyrazol-5(4H)-one plane are 4.97 (9) and 9.91 (9)°, respectively.

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The title compound [systematic name: 9-ethyl-13-hy­droxy-14-methyl-2-(3,4,5-trimeth­oxy-6-methyl­tetra­hydro-2H-pyran-2-yl­oxy)-3,3a,5b,6,9,10,11,12,13,14,16a,16b-dodeca­hydro-1H-as-indaceno[3,2-d][1]oxacyclo­dodecine-7,15(2H,5aH)-dione], C33H50O9, was obtained by hydrolysis of Spinosyn A. The fused cyclo­pentene ring adopts a twisted conformation, while the fused cyclo­hexene and cyclo­pentane rings are in envelope conformations with the same C atom at the flaps. In the crystal, mol­ecules are linked by O—H...O and C—H...O hydrogen bonds into a layer parallel to the ab plane.

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The title compound, C12H17N5O, was obtained by cyclo­condensation of 2,4-diamino­pyrimidine-5-carbonitrile with cyclo­hepta­none. The tetra­hydro­pyrimidine ring has a dis­torted boat conformation and the cyclo­heptane ring adopts a chair conformation. In the crystal, molecules are linked via N—H...O and N—H...N hydrogen bonds generating a three-dimensional network.

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The asymmetric unit of the title compound, C9H12O4, consists of two crystallographically independent mol­ecules with similar conformations: essentially planar [r.m.s deviations for C6O4 = 0.0057 and 0.0137 Å] except for the central meth­oxy-methyl group [C—C—O—C torsion angles = 83.3 (2) and 83.9 (2)°]. In the crystal, O—H...O hydrogen bonds link the mol­ecules, generating supra­molecular chains along the b axis.The three-dimensional crystal structure is stabilized by C—H...O and C—H...π inter­actions.

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In the title gem-dinitro­azetidinium chloride salt, C3H6N3O4+·Cl, the cations and anions lie on a mirror plane. The azetidine ring is virtually planar, with a mean deviation from the plane of 0.0569 Å. The dihedral angle between the two nitro groups is 90.00 (5)°. In the crystal, the ions are linked by N—H...Cl interactions, forming a chain along the c-axis direction, and C—H...O inter­actions, forming a layer parallel to (010).
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