N-Acetyl-L-tyrosine methyl ester monohydrate at 293 and 123 K

The crystal structure of a protected L-tyrosine, namely N-acetyl-L-tyrosine methyl ester monohydrate, C₁₂H₁₅NO₄·H₂O, was determined at both 293 (2) and 123 (2) K. The structure exhibits a network of O—H...O and N—H...O hydrogen bonds, in which the water mol­ecule plays a crucial role as an acceptor of one and a donor of two hydrogen bonds. Mol­ecules of water and of the protected L-tyrosine form hydrogen-bonded layers perpendicular to [001]. C—H...π inter­actions are observed in the hydro­phobic regions of the structure. The structure is similar to that of N-acetyl-L-tyrosine ethyl ester monohydrate [Soriano-García (1993). Acta Cryst. C49, 96–97].