(E)-16-(4-Chloro­benzyl­idene)estrone

In the title compound, C₂₅H₂₅ClO₂, the C ring adopts a chair conformation, while the B ring approximates a half-chair conformation. The five-membered ring D has a twist con­form­ation on the C—C bond fused with the C ring. Aromatic rings A and E are not coplanar, as evidenced by the dihedral angle of 7.51 (1)°. In the crystal, O—H...O hydrogen bonds form a double chain along the ab plane inter­connected by C—H...O inter­actions.

rac-5′′-(4-Fluoro­benzyl­idene)-1′-(4-fluoro­phen­yl)-1′′-methyl-1′,2′,3′,5′,6′,7′,8′,8a′-octa­hydro­dispiro­[acenaphthyl­ene-1,3′-indolizine-2′,3′′-piperidine]-2,4′′(1H)-dione

In the title E isomer of the racemic compound, C₃₇H₃₂F₂N₂O₂, the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by −0.355 (3) Å and with the methyl­ene C atom next to octa­hydro­indolizine moiety deviating by 0.415 (3) Å from the mean plane defined by other four atoms. In the octa­hydro­indolizine system, the pyrrolidine ring exhibits an envelope conformation with the fused methyne C atom deviating by 0.6496 (1) Å from the mean plane defined by four other atoms, and the piperidine ring exhibits a distorted chair conformation as evident from the puckering parameters Q = 0.568 (2) Å, θ = 1.0 (2) and Φ = 256 (11)°. In the crystal, C—H...O inter­actions connect the mol­ecules into chains along [101].