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The title compound, C19H19N3O7S·CH3OH, was synthesized from syringic acid and sulfamethoxazole. The benzene rings make a dihedral angle of 41.8 (1)° and the isoxazole ring is twisted by 74.3 (1)° from the central benzene ring. The crystal packing features O—H...O and O—H...N hydrogen bonds in which the hy­droxy groups from the main mol­ecule and methanol solvent mol­ecules serve as donor groups.
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