A structural and functional investigation of a novel protein from Mycobacterium smegmatis implicated in mycobacterial macrophage survivability

A. Shahine, D. Littler, R. Brammananath, P. Y. Chan, P. K. Crellin, R. L. Coppel, J. Rossjohn and T. Beddoe

The 2.40 Å resolution crystal structure of MSMEG_5817 revealed structural homology to sterol carrier proteins, suggesting a lipid-transport role in the survival of mycobacteria within host macrophages.

Keywords: Mycobacterium smegmatis; MSMEG_5817; selenomethionine; sterol carrier protein; PI3P.

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