A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex

The high-resolution crystal structure of an all-LNA G-quadruplex provides important information on the role of this modified residue on structural and physical properties of quadruplexes. The highly packed assembly observed in the crystal suggests a way by which quadruplexes can be arranged in crowded environments and can be used in nanotechnological applications.