High-resolution structure of the Tiam1 PH_n-CC-Ex domain

The structures of two Tiam1 PH_n-CC-Ex domain variants have been determined to resolutions of 1.98 and 2.15 Å. Biochemical data indicate that this domain binds the coiled-coil domain of Par3b. SAXS data are in excellent agreement with the structures, indicating that the solution and crystal structures are very similar.