Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

The crystal structure of M. tuberculosis L,D-transpeptidase (Ldt_Mt2; Rv2518c) has been determined in both ligand-free and meropenem-bound forms. The detailed view of the interactions between meropenem and Ldt_Mt2 will be useful in structure-guided discovery of new antituberculosis drugs.

Structural and functional characterization of HP0377, a thioredoxin-fold protein from Helicobacter pylori

The results of structural and functional characterizations of H. pylori HP0377, a thioredoxin-fold protein, are reported. HP0377 can reduce apocytochrome c₅₅₃ (HP1227) and forms a covalent complex with a putative L,D-transpeptidase (HP0518) via a disulfide bond, suggesting that HP0377 may serve multiple functions as a reductase in H. pylori.