Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives

H. Niwa, N. Handa, Y. Tomabechi, K. Honda, M. Toyama, N. Ohsawa, M. Shirouzu, H. Kagechika, T. Hirano, T. Umehara and S. Yokoyama

The crystal structures of histone methyltransferase SET7/9 in complexes with two previously developed AdoMet analogues revealed the structural bases for the efficient inhibition of SET7/9 by DAAM-3 and the stabilization of AAM-1, a weaker inhibitor than DAAM-3, within SET7/9 in the crystal.

Keywords: chromatin; epigenetics; methylases; nucleosome.

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