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In the complex between p-cumyl­calix­[4]­arene and para-xyl­ene [systematic name: 4-(2-phenyl­iso­propyl)­calix­[4]­arene-1,4-di­methyl­benzene (1/1)], C64H64O4·C8H10, the macrocycle has a cone conformation, which is stabilized by intramolecular hydrogen bonds. The guest para-xyl­ene mol­ecule is situated inside the cavity, giving an endo-calix complex. The host and guest molecules both have twofold rotation symmetry.
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