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ARCIMBOLDO combines the location of small fragments with Phaser and density modification with SHELXE of all possible Phaser solutions. Its uses are explained and illustrated through practical test cases.

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The 1.0 Å crystal structure of an alternating L-homoalanyl, D-alanyl peptide nucleic acid reveals a novel tetrameric cage with Watson–Crick pairing of the stacked nucleobases.
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