Acta Crystallographica Section D
Acta Crystallographica
Section D
STRUCTURAL BIOLOGY
IUCr
IT
WDC
search IUCr Journals
home
archive
editors
for authors
for readers
submit
subscribe
open access
journal menu
home
archive
editors
for authors
for readers
submit
subscribe
open access
research papers
Share
Share
Issue contents
Article statistics
Download citation
Format
BIBTeX
EndNote
RefMan
Refer
Medline
CIF
SGML
Text
Plain Text
Download PDF of article
Acta Cryst.
(2007).
D
63
,
80-93
https://doi.org/10.1107/S0907444906047287
Download PDF of article
Download citation
Format
BIBTeX
EndNote
RefMan
Refer
Medline
CIF
SGML
Text
Plain Text
Article statistics
Issue contents
Share
Open
access
Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia
S. W. Cowan-Jacob
,
G. Fendrich
,
A. Floersheimer
,
P. Furet
,
J. Liebetanz
,
G. Rummel
,
P. Rheinberger
,
M. Centeleghe
,
D. Fabbro
and
P. W. Manley
A case study showing how the determination of multiple cocrystal structures of the protein tyrosine kinase c-Abl was used to support drug discovery, resulting in a compound effective in the treatment of chronic myelogenous leukaemia.
Keywords:
tyrosine kinase
;
drug discovery
;
imatinib
;
nilotinib
.
Read article
Similar articles
Follow Acta Cryst. D
E-alerts
Twitter
Facebook
RSS