Morphology of polysorbate 80 (Tween 80) micelles in aqueous 1,4-dioxane solutions

Changes in the structure of micelles of the surfactant polysorbate 80 (Tween 80) in 0-50% aqueous 1,4-dioxane solutions (pH 7.2, ionic strength 2.44 mM) were measured by small-angle X-ray scattering. The polysorbate 80 micelles changed from core-shell cylindrical micelles to core-shell discus micelles between concentrations of 20 and 30% 1,4-dioxane, and from core-shell discus micelles to core-shell elliptic discus micelles between concentrations of 40 and 50% 1,4-dioxane.