Crystallization and preliminary crystallographic investigation of a low-pH native insulin monomer with flexible behaviour

Porcine insulin has been crystallized as a monomer in the presence of 20% acetic acid. X-ray data has been collected to 1.6 Å resolution.

Structure of a Cys25→Ser mutant of human cathepsin S

The preparation and crystal structure determination of the active-site Cys25→Ser mutant of human cathepsin S at 2.2 Å resolution is described. This structure clearly defines both the catalytic triad and the substrate-binding region.