Acta Crystallographica Section D
Acta Crystallographica
Section D
STRUCTURAL BIOLOGY
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Acta Cryst.
(2002).
D
58
,
451-455
https://doi.org/10.1107/S0907444901021825
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Structure of a Cys25→Ser mutant of human cathepsin S
J. P. Turkenburg
,
M. B. A. C. Lamers
,
A. M. Brzozowski
,
L. M. Wright
,
R. E. Hubbard
,
S. L. Sturt
and
D. H. Williams
The preparation and crystal structure determination of the active-site Cys25→Ser mutant of human cathepsin S at 2.2 Å resolution is described. This structure clearly defines both the catalytic triad and the substrate-binding region.
Keywords:
cathepsin S
;
cysteine proteinase
;
inhibitor
.
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