Download citation
Acta Cryst. (2014). A70, C1831
Download citation

link to html
A series of copper(II) complexes containing phosphonium substituted hydrazone, (L) with the formulations [CuL]Cl and [Cu(L')L]Cl, where L = doubly deprotonated hydrazone; L' = 1,10'-phenanthroline, 2,2'-bipyridine, 4,4-bipyridine and 5,5'-dimethyl-2,2'-bipyridine has been synthesized. The compounds were characterized by elemental analysis, IR and NMR spectroscopic methods and in the case of crystalline products by X-ray crystallography. The crystal structure of [CuL]Cl and the extent of distortion from ideal square pyramidal geometry for CuL')(l)]Cl will be discussed. The cytotoxicity and topoisomerase I (topo I) inhibition activities of these compounds were also studied. It is noteworthy that the addition of N,N-ligands to the copper(II) complex lead to the enhancement in the cytotoxicity of the compounds, especially against human prostate adenocarcinoma cell line (PC-3). The complexes can also inhibit topo I through the binding to DNA and the enzyme.
Follow Acta Cryst. A
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds