Crystal structure of salts luminol with Li, Na and K

The molecular and crystal structures of new drugs Tamerit® (A) and Galavit® (B) which possess high effective immunomodulator, anti-inflammatory and anti-oxidant properties, were studied by single crystal and powder X-ray diffraction methods. As shown, A and B are aminodihydrophtalazindion (luminol) sodium salts, but A - is a dihydrate form and B anhydrous one, moreover it is a mixture two different crystal phases B1 and B2. The phase transition B1 <---> B2 is not registered by DSC method [1]. Crystal data for A: monoclinic system with a = 8.3429(4), b = 22.0562(11), c =5.2825(2) Å, β = 99.893(3)o, V = 957.59(8) Å3, Z = 4, sp.gr. R21/s. Crystal data for B1: monoclinic system with a = 14.7157(18), b = 3.7029(19), c = 16.0233(15) Å, β = 116.682(13)o, V = 780.1(4) Å3, Z = 4, sp.gr. R21/s. Crystal data for B2: orthorhombic system with a = 27.7765(15), b = 3.3980(19), c = 8.1692(19) Å, V = 771.0(5) Å3, Z = 4, sp.gr. Pna21. As a continuation of this work, we studied by the same methods other luminol salts: with Li - monohydrate (C1) and anhydrous (C2) and with K - trihydrate (D1) and anhydrous (D2). Crystal data for C1: monoclinic system with a = 13.0311(15), b = 9.6002(7), c = 7.3227(7) Å, β = 101.320(9)o, V = 898.26(15) Å3, Z = 4, sp.gr. R21/s. Crystal data for C2: monoclinic system with a = 13.0979(14), b = 8.7537(12), c = 14.5358(17) Å, β = 107.061(16)o, V = 1593.3(4) Å3, Z = 8, sp.gr. C2/c. Crystal data for D1: monoclinic system with a = 10.6760(6), b = 14.2905(8), c = 7.4902(5) Å, β = 99.246(5)o, V = 1127.90(12) Å3, Z = 4, sp.gr. R21/s. Crystal data for D2: orthorhombic system with a = 27.3961(19), b = 3.6811(14), c = 8.6672(12) Å, V = 874.1(4) Å3, Z = 4, sp.gr. Pna21 [2]. All X-ray experiments were made at T = 295 K. The features of molecular and crystal structures are discussed.