Acta Crystallographica Section F

Structural Biology and Crystallization Communications

Volume 62, Part 5 (May 2006)

structural genomics communications

 

Structure of ribose 5-phosphate isomerase from Plasmodium falciparum

M. A. Holmes, F. S. Buckner, W. C. Van Voorhis, C. L. M. J. Verlinde, C. Mehlin, E. Boni, G. DeTitta, J. Luft, A. Lauricella, L. Anderson, O. Kalyuzhniy, F. Zucker, L. W. Schoenfeld, T. N. Earnest, W. G. J. Hol and E. A. Merritt

Abstract: The structure of ribose 5-phosphate isomerase from Plasmodium falciparum, PFE0730c, has been determined by molecular replacement at 2.09 Å resolution. The enzyme, which catalyzes the isomerization reaction that interconverts ribose 5-phosphate and ribulose 5-phosphate, is a member of the pentose phosphate pathway. The P. falciparum enzyme belongs to the ribose 5-phosphate isomerase A family, Pfam family PF06562 (DUF1124), and is structurally similar to other members of the family.

PDB reference: 2f8m

Keywords: ribose 5-phosphate isomerase.

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