research communications
Peroxiredoxins (Prxs), a large family of antioxidant enzymes, are abundant in all living organisms. Peroxiredoxin A (PrxA) from Arabidopsis thaliana belongs to the typical 2-Cys Prx family and is localized in the chloroplast. This article reports the crystal structure of a PrxA C119S mutant refined to 2.6 Å resolution. The protein exists as a decamer both in the crystal structure and in solution. The structure is in the reduced state suitable for the approach of peroxide, though conformational changes are needed for the resolving process.
Keywords: peroxiredoxins; peroxiredoxin A; Arabidopsis thaliana; redox regulation; chloroplast thioredoxin systems; oxidative and photo-oxidative stress.
Supporting information
Portable Document Format (PDF) file https://doi.org/10.1107/S2053230X18010920/tb5126sup1.pdf |
PDB reference: Arabidopsis thaliana peroxiredoxin A C119S mutant, 5zte