protein structure communications
Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 Å resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.
Supporting information
PDB references: A. globiformis amine oxidase, benzylhydrazine complex, 1w5z, r1w5zsf; tranylcypromine complex, 1w4n, r1w4nsf