Buy article online - an online subscription or single-article purchase is required to access this article.
Download citation
Download citation
link to html
The title compound (systematic name: 17-ethyl­idene-4,4,13,14-tetra­methyl-3-methyl­amino­dodeca­hydro­cyclo­propa[9,10]cyclo­penta­[a]phenanthren-16-one), C25H39NO, was semi-synthesized from cyclo­virobuxine D. It has a four-ring triterpenoid nucleus in a trans–cis–trans configuration. The carbonyl and methyl groups have a trans configuration about the C=C bond in the α,β-unsaturated ketone group.

Supporting information

cif

Crystallographic Information File (CIF) https://doi.org/10.1107/S160053680701495X/sk3099sup1.cif
Contains datablocks I, global

hkl

Structure factor file (CIF format) https://doi.org/10.1107/S160053680701495X/sk3099Isup2.hkl
Contains datablock I

CCDC reference: 648230

Key indicators

  • Single-crystal X-ray study
  • T = 193 K
  • Mean [sigma](C-C) = 0.005 Å
  • R factor = 0.058
  • wR factor = 0.119
  • Data-to-parameter ratio = 8.9

checkCIF/PLATON results

No syntax errors found



Alert level C ABSTM02_ALERT_3_C The ratio of expected to reported Tmax/Tmin(RR') is < 0.90 Tmin and Tmax reported: 0.776 0.987 Tmin(prime) and Tmax expected: 0.971 0.986 RR(prime) = 0.799 Please check that your absorption correction is appropriate. PLAT061_ALERT_3_C Tmax/Tmin Range Test RR' too Large ............. 0.80 PLAT220_ALERT_2_C Large Non-Solvent C Ueq(max)/Ueq(min) ... 2.86 Ratio PLAT222_ALERT_3_C Large Non-Solvent H Ueq(max)/Ueq(min) ... 3.56 Ratio PLAT340_ALERT_3_C Low Bond Precision on C-C bonds (x 1000) Ang ... 5 PLAT420_ALERT_2_C D-H Without Acceptor N1 - H1 ... ?
Alert level G REFLT03_ALERT_4_G Please check that the estimate of the number of Friedel pairs is correct. If it is not, please give the correct count in the _publ_section_exptl_refinement section of the submitted CIF. From the CIF: _diffrn_reflns_theta_max 25.35 From the CIF: _reflns_number_total 2269 Count of symmetry unique reflns 2281 Completeness (_total/calc) 99.47% TEST3: Check Friedels for noncentro structure Estimate of Friedel pairs measured 0 Fraction of Friedel pairs measured 0.000 Are heavy atom types Z>Si present no PLAT791_ALERT_1_G Confirm the Absolute Configuration of C3 = . S PLAT791_ALERT_1_G Confirm the Absolute Configuration of C4 = . S PLAT791_ALERT_1_G Confirm the Absolute Configuration of C6 = . S PLAT791_ALERT_1_G Confirm the Absolute Configuration of C12 = . R PLAT791_ALERT_1_G Confirm the Absolute Configuration of C17 = . S
0 ALERT level A = In general: serious problem 0 ALERT level B = Potentially serious problem 6 ALERT level C = Check and explain 6 ALERT level G = General alerts; check 5 ALERT type 1 CIF construction/syntax error, inconsistent or missing data 2 ALERT type 2 Indicator that the structure model may be wrong or deficient 4 ALERT type 3 Indicator that the structure quality may be low 1 ALERT type 4 Improvement, methodology, query or suggestion 0 ALERT type 5 Informative message, check

Computing details top

Data collection: CrystalClear (Rigaku, 2000); cell refinement: CrystalClear; data reduction: CrystalStructure (Rigaku, 2000); program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: SHELXTL (Siemens, 1994); software used to prepare material for publication: SHELXTL and PLATON (Spek, 2003).

17-ethylidene-4,4,13,14-tetramethyl-3- methylaminododecahydrocyclopropa[9,10]cyclopenta[a]phenanthren-16-one top
Crystal data top
C25H39NODx = 1.144 Mg m3
Mr = 369.57Melting point = 434–435 K
Orthorhombic, P212121Mo Kα radiation, λ = 0.71070 Å
Hall symbol: P 2ac 2abCell parameters from 7398 reflections
a = 7.1102 (13) Åθ = 3.2–25.3°
b = 11.054 (2) ŵ = 0.07 mm1
c = 27.294 (5) ÅT = 193 K
V = 2145.2 (7) Å3Block, colorless
Z = 40.42 × 0.40 × 0.20 mm
F(000) = 816
Data collection top
Rigaku Mercury
diffractometer
2269 independent reflections
Radiation source: fine-focus sealed tube2128 reflections with I > 2σ(I)
Graphite monochromatorRint = 0.061
Detector resolution: 7.31 pixels mm-1θmax = 25.4°, θmin = 3.2°
ω scansh = 88
Absorption correction: multi-scan
(Jacobson, 1998)
k = 1313
Tmin = 0.776, Tmax = 0.987l = 3232
20717 measured reflections
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.058Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.119H atoms treated by a mixture of independent and constrained refinement
S = 1.01 w = 1/[σ2(Fo2) + (0.0376P)2 + 1.5605P]
where P = (Fo2 + 2Fc2)/3
2269 reflections(Δ/σ)max < 0.001
255 parametersΔρmax = 0.16 e Å3
0 restraintsΔρmin = 0.18 e Å3
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
O10.1216 (4)0.8705 (3)0.19647 (9)0.0588 (8)
N10.2315 (5)0.4117 (3)0.57886 (12)0.0497 (8)
H10.237 (6)0.330 (4)0.5684 (15)0.070 (14)*
C10.1742 (5)0.8049 (3)0.22956 (13)0.0406 (8)
C20.3553 (5)0.7369 (3)0.23114 (12)0.0346 (8)
C30.3517 (5)0.6595 (3)0.27698 (11)0.0326 (7)
C40.2219 (4)0.7348 (3)0.31148 (11)0.0315 (7)
C50.0675 (5)0.7792 (3)0.27645 (12)0.0393 (8)
H5A0.02940.71620.27130.047*
H5B0.00630.85340.28910.047*
C60.1516 (4)0.6556 (3)0.35382 (11)0.0305 (7)
H60.06540.59450.33880.037*
C70.3132 (4)0.5831 (3)0.37769 (11)0.0301 (7)
C80.5143 (5)0.6056 (3)0.35858 (12)0.0384 (8)
H8A0.59010.53260.36570.046*
H8B0.56900.67290.37780.046*
C90.5392 (5)0.6362 (3)0.30324 (12)0.0388 (8)
H9A0.61970.70880.30010.047*
H9B0.60460.56820.28690.047*
C100.2612 (5)0.4550 (3)0.39277 (12)0.0361 (8)
H10A0.12990.42850.38730.043*
H10B0.35710.39110.38830.043*
C110.2961 (5)0.5491 (3)0.43197 (11)0.0320 (7)
C120.1343 (4)0.5987 (3)0.46305 (11)0.0297 (7)
H120.18470.67430.47830.036*
C130.0321 (5)0.6394 (3)0.43223 (11)0.0342 (8)
H13A0.12460.68170.45320.041*
H13B0.09460.56800.41760.041*
C140.0344 (5)0.7243 (3)0.39165 (11)0.0341 (8)
H14A0.11080.79010.40610.041*
H14B0.07600.76120.37540.041*
C150.4712 (5)0.5335 (3)0.46266 (13)0.0388 (8)
H15A0.51290.61310.47520.047*
H15B0.57350.49940.44230.047*
C160.4300 (5)0.4491 (3)0.50527 (13)0.0421 (9)
H16A0.54400.44210.52590.051*
H16B0.40070.36760.49230.051*
C170.2664 (5)0.4919 (3)0.53701 (12)0.0358 (8)
H170.30440.57190.55090.043*
C180.0854 (5)0.5144 (3)0.50687 (12)0.0337 (8)
C190.4766 (5)0.7474 (3)0.19422 (13)0.0390 (8)
H190.44130.80290.16930.047*
C200.6601 (6)0.6847 (4)0.18633 (14)0.0496 (10)
H20A0.67960.62480.21230.074*
H20B0.76230.74420.18710.074*
H20C0.65890.64400.15440.074*
C210.2637 (5)0.5362 (3)0.26292 (12)0.0412 (9)
H21A0.33960.49810.23720.062*
H21B0.13540.54900.25080.062*
H21C0.26020.48360.29180.062*
C220.3253 (6)0.8493 (3)0.32973 (12)0.0413 (9)
H22A0.23460.90470.34480.062*
H22B0.38650.88950.30200.062*
H22C0.42050.82620.35400.062*
C230.0001 (5)0.3929 (3)0.49034 (14)0.0425 (9)
H23A0.11060.40810.46980.064*
H23B0.03710.34580.51920.064*
H23C0.09360.34740.47150.064*
C240.0572 (5)0.5778 (3)0.54015 (12)0.0431 (9)
H24A0.17720.58620.52280.065*
H24B0.00970.65800.54900.065*
H24C0.07590.52960.56990.065*
C250.3646 (8)0.4276 (5)0.61868 (15)0.0851 (17)
H25A0.34180.50550.63470.128*
H25B0.49300.42590.60570.128*
H25C0.34890.36210.64250.128*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
O10.0522 (16)0.0773 (19)0.0468 (15)0.0143 (16)0.0053 (14)0.0236 (15)
N10.0510 (19)0.053 (2)0.0450 (18)0.0064 (18)0.0010 (16)0.0211 (17)
C10.0381 (19)0.046 (2)0.0381 (18)0.0004 (18)0.0020 (17)0.0038 (17)
C20.0354 (18)0.0361 (18)0.0322 (16)0.0060 (16)0.0013 (15)0.0030 (15)
C30.0301 (16)0.0344 (17)0.0332 (17)0.0005 (16)0.0027 (15)0.0008 (15)
C40.0285 (17)0.0359 (17)0.0301 (16)0.0008 (15)0.0009 (14)0.0001 (14)
C50.0343 (18)0.049 (2)0.0345 (18)0.0061 (17)0.0024 (15)0.0044 (16)
C60.0270 (16)0.0349 (18)0.0296 (16)0.0000 (15)0.0009 (14)0.0001 (14)
C70.0250 (16)0.0344 (17)0.0308 (16)0.0032 (15)0.0023 (14)0.0004 (14)
C80.0279 (17)0.051 (2)0.0362 (19)0.0004 (17)0.0016 (15)0.0061 (16)
C90.0309 (17)0.048 (2)0.0371 (18)0.0035 (18)0.0051 (16)0.0005 (17)
C100.0329 (18)0.0342 (18)0.0411 (19)0.0065 (16)0.0092 (16)0.0029 (15)
C110.0292 (17)0.0353 (17)0.0317 (17)0.0007 (15)0.0012 (14)0.0016 (14)
C120.0270 (16)0.0303 (16)0.0317 (16)0.0013 (15)0.0029 (14)0.0020 (14)
C130.0265 (16)0.0423 (18)0.0339 (17)0.0049 (16)0.0050 (14)0.0007 (15)
C140.0294 (17)0.0392 (18)0.0337 (17)0.0067 (17)0.0038 (15)0.0018 (15)
C150.0313 (18)0.047 (2)0.0381 (19)0.0024 (17)0.0011 (16)0.0095 (16)
C160.0351 (19)0.045 (2)0.046 (2)0.0025 (17)0.0017 (17)0.0158 (18)
C170.0367 (19)0.0375 (18)0.0331 (18)0.0043 (16)0.0018 (16)0.0066 (15)
C180.0364 (19)0.0290 (17)0.0356 (18)0.0018 (15)0.0036 (15)0.0017 (14)
C190.0404 (19)0.0393 (19)0.0371 (18)0.0026 (18)0.0024 (17)0.0036 (16)
C200.052 (2)0.048 (2)0.048 (2)0.002 (2)0.016 (2)0.0036 (18)
C210.051 (2)0.0358 (19)0.0371 (19)0.0046 (18)0.0101 (18)0.0074 (15)
C220.046 (2)0.0395 (19)0.0382 (18)0.0059 (19)0.0058 (17)0.0013 (16)
C230.043 (2)0.0331 (18)0.052 (2)0.0083 (17)0.0044 (18)0.0013 (16)
C240.048 (2)0.045 (2)0.0358 (19)0.0030 (19)0.0088 (17)0.0020 (17)
C250.087 (4)0.117 (4)0.051 (3)0.029 (4)0.017 (3)0.041 (3)
Geometric parameters (Å, º) top
O1—C11.217 (4)C13—C141.526 (4)
N1—C251.452 (5)C13—H13A0.9900
N1—C171.467 (4)C13—H13B0.9900
N1—H10.95 (4)C14—H14A0.9900
C1—C21.491 (5)C14—H14B0.9900
C1—C51.515 (5)C15—C161.520 (4)
C2—C191.332 (5)C15—H15A0.9900
C2—C31.516 (5)C15—H15B0.9900
C3—C91.536 (5)C16—C171.525 (5)
C3—C211.548 (4)C16—H16A0.9900
C3—C41.559 (4)C16—H16B0.9900
C4—C61.534 (4)C17—C181.548 (5)
C4—C51.537 (4)C17—H171.0000
C4—C221.545 (5)C18—C241.531 (5)
C5—H5A0.9900C18—C231.541 (4)
C5—H5B0.9900C19—C201.493 (5)
C6—C141.529 (4)C19—H190.9500
C6—C71.545 (4)C20—H20A0.9800
C6—H61.0000C20—H20B0.9800
C7—C101.520 (5)C20—H20C0.9800
C7—C111.533 (4)C21—H21A0.9800
C7—C81.543 (4)C21—H21B0.9800
C8—C91.558 (4)C21—H21C0.9800
C8—H8A0.9900C22—H22A0.9800
C8—H8B0.9900C22—H22B0.9800
C9—H9A0.9900C22—H22C0.9800
C9—H9B0.9900C23—H23A0.9800
C10—C111.512 (5)C23—H23B0.9800
C10—H10A0.9900C23—H23C0.9800
C10—H10B0.9900C24—H24A0.9800
C11—C151.511 (5)C24—H24B0.9800
C11—C121.530 (4)C24—H24C0.9800
C12—C131.520 (4)C25—H25A0.9800
C12—C181.556 (4)C25—H25B0.9800
C12—H121.0000C25—H25C0.9800
C25—N1—C17113.5 (3)C12—C13—H13B109.7
C25—N1—H1108 (3)C14—C13—H13B109.7
C17—N1—H1110 (3)H13A—C13—H13B108.2
O1—C1—C2125.9 (3)C13—C14—C6110.7 (3)
O1—C1—C5125.7 (3)C13—C14—H14A109.5
C2—C1—C5108.3 (3)C6—C14—H14A109.5
C19—C2—C1119.6 (3)C13—C14—H14B109.5
C19—C2—C3133.2 (3)C6—C14—H14B109.5
C1—C2—C3107.1 (3)H14A—C14—H14B108.1
C2—C3—C9117.7 (3)C11—C15—C16109.6 (3)
C2—C3—C21107.4 (3)C11—C15—H15A109.7
C9—C3—C21108.6 (3)C16—C15—H15A109.7
C2—C3—C4102.0 (2)C11—C15—H15B109.7
C9—C3—C4108.8 (3)C16—C15—H15B109.7
C21—C3—C4112.4 (3)H15A—C15—H15B108.2
C6—C4—C5114.7 (3)C15—C16—C17113.0 (3)
C6—C4—C22112.3 (3)C15—C16—H16A109.0
C5—C4—C22106.2 (3)C17—C16—H16A109.0
C6—C4—C3110.1 (3)C15—C16—H16B109.0
C5—C4—C3102.6 (3)C17—C16—H16B109.0
C22—C4—C3110.5 (3)H16A—C16—H16B107.8
C1—C5—C4103.1 (3)N1—C17—C16112.6 (3)
C1—C5—H5A111.1N1—C17—C18111.7 (3)
C4—C5—H5A111.1C16—C17—C18112.5 (3)
C1—C5—H5B111.1N1—C17—H17106.5
C4—C5—H5B111.1C16—C17—H17106.5
H5A—C5—H5B109.1C18—C17—H17106.5
C14—C6—C4113.8 (3)C24—C18—C23108.2 (3)
C14—C6—C7112.2 (3)C24—C18—C17108.0 (3)
C4—C6—C7111.8 (3)C23—C18—C17110.0 (3)
C14—C6—H6106.1C24—C18—C12109.3 (3)
C4—C6—H6106.1C23—C18—C12112.6 (3)
C7—C6—H6106.1C17—C18—C12108.6 (3)
C10—C7—C1159.4 (2)C2—C19—C20129.4 (3)
C10—C7—C8117.9 (3)C2—C19—H19115.3
C11—C7—C8116.1 (3)C20—C19—H19115.3
C10—C7—C6114.6 (3)C19—C20—H20A109.5
C11—C7—C6118.4 (3)C19—C20—H20B109.5
C8—C7—C6117.6 (3)H20A—C20—H20B109.5
C7—C8—C9117.9 (3)C19—C20—H20C109.5
C7—C8—H8A107.8H20A—C20—H20C109.5
C9—C8—H8A107.8H20B—C20—H20C109.5
C7—C8—H8B107.8C3—C21—H21A109.5
C9—C8—H8B107.8C3—C21—H21B109.5
H8A—C8—H8B107.2H21A—C21—H21B109.5
C3—C9—C8113.0 (3)C3—C21—H21C109.5
C3—C9—H9A109.0H21A—C21—H21C109.5
C8—C9—H9A109.0H21B—C21—H21C109.5
C3—C9—H9B109.0C4—C22—H22A109.5
C8—C9—H9B109.0C4—C22—H22B109.5
H9A—C9—H9B107.8H22A—C22—H22B109.5
C11—C10—C760.8 (2)C4—C22—H22C109.5
C11—C10—H10A117.7H22A—C22—H22C109.5
C7—C10—H10A117.7H22B—C22—H22C109.5
C11—C10—H10B117.7C18—C23—H23A109.5
C7—C10—H10B117.7C18—C23—H23B109.5
H10A—C10—H10B114.8H23A—C23—H23B109.5
C15—C11—C10116.7 (3)C18—C23—H23C109.5
C15—C11—C12110.7 (3)H23A—C23—H23C109.5
C10—C11—C12121.0 (3)H23B—C23—H23C109.5
C15—C11—C7119.9 (3)C18—C24—H24A109.5
C10—C11—C759.9 (2)C18—C24—H24B109.5
C12—C11—C7120.5 (3)H24A—C24—H24B109.5
C13—C12—C11112.6 (3)C18—C24—H24C109.5
C13—C12—C18115.4 (3)H24A—C24—H24C109.5
C11—C12—C18112.3 (3)H24B—C24—H24C109.5
C13—C12—H12105.1N1—C25—H25A109.5
C11—C12—H12105.1N1—C25—H25B109.5
C18—C12—H12105.1H25A—C25—H25B109.5
C12—C13—C14110.0 (3)N1—C25—H25C109.5
C12—C13—H13A109.7H25A—C25—H25C109.5
C14—C13—H13A109.7H25B—C25—H25C109.5
O1—C1—C2—C191.1 (5)C6—C7—C10—C11109.7 (3)
C5—C1—C2—C19178.3 (3)C7—C10—C11—C15110.7 (3)
O1—C1—C2—C3175.1 (4)C7—C10—C11—C12109.6 (3)
C5—C1—C2—C35.4 (4)C10—C7—C11—C15105.4 (3)
C19—C2—C3—C937.2 (5)C8—C7—C11—C153.0 (4)
C1—C2—C3—C9147.2 (3)C6—C7—C11—C15151.3 (3)
C19—C2—C3—C2185.6 (5)C8—C7—C11—C10108.4 (3)
C1—C2—C3—C2190.0 (3)C6—C7—C11—C10103.3 (3)
C19—C2—C3—C4156.1 (4)C10—C7—C11—C12110.5 (3)
C1—C2—C3—C428.3 (3)C8—C7—C11—C12141.2 (3)
C2—C3—C4—C6163.0 (3)C6—C7—C11—C127.1 (4)
C9—C3—C4—C672.0 (3)C15—C11—C12—C13168.6 (3)
C21—C3—C4—C648.3 (4)C10—C11—C12—C1349.6 (4)
C2—C3—C4—C540.4 (3)C7—C11—C12—C1321.4 (4)
C9—C3—C4—C5165.5 (3)C15—C11—C12—C1859.1 (4)
C21—C3—C4—C574.3 (3)C10—C11—C12—C1882.7 (4)
C2—C3—C4—C2272.4 (3)C7—C11—C12—C18153.7 (3)
C9—C3—C4—C2252.6 (3)C11—C12—C13—C1451.0 (4)
C21—C3—C4—C22172.9 (3)C18—C12—C13—C14178.3 (3)
O1—C1—C5—C4159.2 (4)C12—C13—C14—C668.7 (3)
C2—C1—C5—C420.3 (4)C4—C6—C14—C13179.4 (3)
C6—C4—C5—C1156.6 (3)C7—C6—C14—C1352.4 (4)
C22—C4—C5—C178.7 (3)C10—C11—C15—C1685.7 (3)
C3—C4—C5—C137.3 (3)C12—C11—C15—C1658.0 (4)
C5—C4—C6—C1469.1 (4)C7—C11—C15—C16154.6 (3)
C22—C4—C6—C1452.3 (4)C11—C15—C16—C1756.4 (4)
C3—C4—C6—C14175.9 (3)C25—N1—C17—C1677.2 (5)
C5—C4—C6—C7162.5 (3)C25—N1—C17—C18155.1 (4)
C22—C4—C6—C776.1 (3)C15—C16—C17—N1178.3 (3)
C3—C4—C6—C747.4 (3)C15—C16—C17—C1854.4 (4)
C14—C6—C7—C1089.2 (3)N1—C17—C18—C2462.2 (4)
C4—C6—C7—C10141.5 (3)C16—C17—C18—C24170.1 (3)
C14—C6—C7—C1122.1 (4)N1—C17—C18—C2355.7 (4)
C4—C6—C7—C11151.4 (3)C16—C17—C18—C2372.1 (4)
C14—C6—C7—C8125.7 (3)N1—C17—C18—C12179.4 (3)
C4—C6—C7—C83.6 (4)C16—C17—C18—C1251.7 (4)
C10—C7—C8—C9110.5 (4)C13—C12—C18—C2457.0 (4)
C11—C7—C8—C9178.0 (3)C11—C12—C18—C24172.1 (3)
C6—C7—C8—C933.4 (5)C13—C12—C18—C2363.2 (4)
C2—C3—C9—C8155.7 (3)C11—C12—C18—C2367.6 (4)
C21—C3—C9—C882.0 (4)C13—C12—C18—C17174.6 (3)
C4—C3—C9—C840.5 (4)C11—C12—C18—C1754.5 (3)
C7—C8—C9—C39.3 (5)C1—C2—C19—C20176.7 (3)
C8—C7—C10—C11105.4 (3)C3—C2—C19—C201.5 (6)
 

Subscribe to Acta Crystallographica Section E: Crystallographic Communications

The full text of this article is available to subscribers to the journal.

If you have already registered and are using a computer listed in your registration details, please email support@iucr.org for assistance.

Buy online

You may purchase this article in PDF and/or HTML formats. For purchasers in the European Community who do not have a VAT number, VAT will be added at the local rate. Payments to the IUCr are handled by WorldPay, who will accept payment by credit card in several currencies. To purchase the article, please complete the form below (fields marked * are required), and then click on `Continue'.
E-mail address* 
Repeat e-mail address* 
(for error checking) 

Format*   PDF (US $40)
   HTML (US $40)
   PDF+HTML (US $50)
In order for VAT to be shown for your country javascript needs to be enabled.

VAT number 
(non-UK EC countries only) 
Country* 
 

Terms and conditions of use
Contact us

Follow Acta Cryst. E
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds