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The reaction of different substituted
-cyanooxiranes with thiourea resulted in the formation of the 2-aminothiazolinone derivative 2-amino-5-(2,5-dimethoxyphenyl)-1,3-thiazol-4(5
H)-one, C
11H
12N
2O
3S, (I), and the 2-aminothiazole derivative ethyl 2-amino-5-(2,5-dimethoxyphenyl)-1,3-thiazole-4-carboxylate, C
14H
16N
2O
4S, (II). The geometries of the two crystallographically independent molecules in (II) are nearly identical but mirror related. The crystal structures of both compounds contain two types of intermolecular hydrogen bonds.
Supporting information
CCDC references: 221075; 221076
For the preparation of (I), a mixture of 3-(2,5-dimethoxyphenyl)-2,2-oxiranedicarbonitrile (0.230 g, 1 mmol) and thiourea (0.076 g, 1 mmol) was dissolved in acetonitrile (5 ml) and stirred at room temperature for 24 h. The product precipitated from the reaction mixture in 68% yield (m.p. 469–471 K). 1H NMR (300 MHz, DMSO, p.p.m.): δ 3.68 (s, 3H), 3.70 (s, 3H), 5.34 (s, 1H), 6.73 (d, 1H), 6.87 (dd, 1H), 6.93 (d, 1H), 8.73 (s, 1H), 8.99 (s, 1H). Analysis found: C 52.08, H 4.36, N 10.96%; calculated for C11H12N2O3S: C 52.37, H 4.79, N 11.10%. Crystals suitable for X-ray diffraction were obtained by recrystallization from ethanol. For the preparation of (II), a mixture of ethyl 2-cyano-3-(2,5-dimethoxyphenyl)-2-oxiranecarboxylate (0.277 g, 1 mmol) and thiourea (0.076 g, 1 mmol) was dissolved in acetonitrile (5 ml) and refluxed for 6 h. Water (50 ml) was added to the reaction mixture and the solution was extracted with ether (3 x 50 ml). The organic layers were combined and dried over sodium sulfate(VI), and the solid residue was recrystallized from ethanol to give (II) in 49% yield (m.p. 404–405 K). 1H NMR (300 MHz, DMSO, p.p.m.): δ 1.03 (t, 3H), 3.66 (s, 3H), 3.71 (s, 3H), 4.01 (q, 2H), 6.79 (d, 1H), 6.89 (dd, 1H), 6.99 (d, 1H), 7.20 (s, 2H).
For (I), all H atoms were located in difference Fourier syntheses and were included in the refinement. For (II), H atoms were placed at calculated positions and treated as riding.
Data collection: Collect (Nonius, 1998) for (I); Collect Software (Nonius,1998) for (II). Cell refinement: DENZO and SCALEPACK (Otwinowski & Minor, 1997) for (I); DENZO and SCALEPACK (Otwinowski & Minor,1997) for (II). Data reduction: DENZO AND SCALEPACK for (I); DENZO AND SCALEPACK (Otwinowski & Minor, 1997) for (II). For both compounds, program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEP-3 for Windows (Farrugia,1997). Software used to prepare material for publication: SHELXL97 and PLATON (Spek, 1998) for (I); SHELXL97 (Sheldrick,1997), PLATON (Spek, 1998) for (II).
(I) 2-amino-5-(2,5-dimethoxyphenyl)-1,3-thiazol-4(5
H)-one
top
Crystal data top
C11H12N2O3S | Z = 2 |
Mr = 252.29 | F(000) = 264 |
Triclinic, P1 | Dx = 1.493 Mg m−3 |
Hall symbol: -P 1 | Mo Kα radiation, λ = 0.71073 Å |
a = 6.9572 (5) Å | Cell parameters from all reflections |
b = 8.1499 (7) Å | θ = 2.9–27.5° |
c = 10.4564 (10) Å | µ = 0.29 mm−1 |
α = 99.800 (2)° | T = 293 K |
β = 101.050 (2)° | Prism, colourless |
γ = 99.540 (2)° | 0.40 × 0.35 × 0.30 mm |
V = 561.21 (8) Å3 | |
Data collection top
Nonius KappaCCD diffractometer | 2349 reflections with I > 2σ(I) |
Radiation source: fine-focus sealed tube | Rint = 0.014 |
Graphite monochromator | θmax = 27.5°, θmin = 2.9° |
ϕ and ω scans | h = −8→9 |
3846 measured reflections | k = −10→10 |
2490 independent reflections | l = −12→13 |
Refinement top
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.029 | Hydrogen site location: difference Fourier map |
wR(F2) = 0.078 | All H-atom parameters refined |
S = 1.05 | w = 1/[σ2(Fo2) + (0.0341P)2 + 0.1774P] where P = (Fo2 + 2Fc2)/3 |
2490 reflections | (Δ/σ)max = 0.001 |
202 parameters | Δρmax = 0.27 e Å−3 |
0 restraints | Δρmin = −0.22 e Å−3 |
Crystal data top
C11H12N2O3S | γ = 99.540 (2)° |
Mr = 252.29 | V = 561.21 (8) Å3 |
Triclinic, P1 | Z = 2 |
a = 6.9572 (5) Å | Mo Kα radiation |
b = 8.1499 (7) Å | µ = 0.29 mm−1 |
c = 10.4564 (10) Å | T = 293 K |
α = 99.800 (2)° | 0.40 × 0.35 × 0.30 mm |
β = 101.050 (2)° | |
Data collection top
Nonius KappaCCD diffractometer | 2349 reflections with I > 2σ(I) |
3846 measured reflections | Rint = 0.014 |
2490 independent reflections | |
Refinement top
R[F2 > 2σ(F2)] = 0.029 | 0 restraints |
wR(F2) = 0.078 | All H-atom parameters refined |
S = 1.05 | Δρmax = 0.27 e Å−3 |
2490 reflections | Δρmin = −0.22 e Å−3 |
202 parameters | |
Special details top
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top | x | y | z | Uiso*/Ueq | |
S1 | 0.55666 (4) | 0.59805 (4) | 0.66437 (3) | 0.03000 (11) | |
O4 | 0.07240 (13) | 0.62722 (12) | 0.78502 (9) | 0.0365 (2) | |
O12 | 0.41528 (15) | 0.95265 (11) | 0.77662 (9) | 0.0393 (2) | |
O14 | 0.05392 (16) | 0.82197 (14) | 0.24062 (10) | 0.0481 (3) | |
N2 | 0.71460 (17) | 0.55027 (16) | 0.90370 (11) | 0.0368 (2) | |
N3 | 0.38166 (15) | 0.57493 (13) | 0.86499 (9) | 0.0296 (2) | |
C2 | 0.55238 (17) | 0.57240 (14) | 0.82656 (11) | 0.0263 (2) | |
C4 | 0.23831 (16) | 0.60987 (13) | 0.77023 (11) | 0.0262 (2) | |
C5 | 0.29562 (16) | 0.61638 (14) | 0.63517 (11) | 0.0249 (2) | |
C6 | 0.25934 (16) | 0.76502 (14) | 0.57272 (11) | 0.0253 (2) | |
C7 | 0.16979 (17) | 0.73475 (15) | 0.43822 (12) | 0.0285 (2) | |
C8 | 0.14498 (18) | 0.86868 (17) | 0.37384 (13) | 0.0343 (3) | |
C9 | 0.2108 (2) | 1.03383 (17) | 0.44517 (15) | 0.0394 (3) | |
C10 | 0.3012 (2) | 1.06602 (16) | 0.57982 (15) | 0.0376 (3) | |
C11 | 0.32656 (17) | 0.93353 (15) | 0.64472 (12) | 0.0303 (2) | |
C13 | 0.4826 (3) | 1.1233 (2) | 0.85348 (19) | 0.0529 (4) | |
C15 | 0.0463 (3) | 0.9545 (3) | 0.1677 (2) | 0.0575 (4) | |
H7 | 0.126 (2) | 0.6212 (19) | 0.3880 (15) | 0.035 (4)* | |
H5 | 0.219 (2) | 0.5100 (18) | 0.5741 (14) | 0.030 (3)* | |
H13A | 0.367 (3) | 1.180 (3) | 0.854 (2) | 0.069 (6)* | |
H2A | 0.705 (3) | 0.524 (2) | 0.9833 (19) | 0.054 (5)* | |
H13B | 0.585 (3) | 1.185 (3) | 0.815 (2) | 0.067 (6)* | |
H13C | 0.545 (3) | 1.112 (3) | 0.943 (2) | 0.073 (6)* | |
H15A | −0.016 (3) | 0.894 (3) | 0.075 (2) | 0.079 (7)* | |
H15B | 0.180 (3) | 1.022 (2) | 0.1770 (19) | 0.060 (5)* | |
H15C | −0.039 (3) | 1.032 (3) | 0.197 (2) | 0.075 (6)* | |
H2B | 0.824 (3) | 0.554 (2) | 0.8758 (17) | 0.047 (4)* | |
H10 | 0.348 (3) | 1.181 (2) | 0.6283 (17) | 0.050 (4)* | |
H9 | 0.189 (3) | 1.124 (2) | 0.4044 (18) | 0.055 (5)* | |
Atomic displacement parameters (Å2) top | U11 | U22 | U33 | U12 | U13 | U23 |
S1 | 0.03223 (17) | 0.04005 (18) | 0.02628 (16) | 0.01544 (12) | 0.01433 (11) | 0.01368 (12) |
O4 | 0.0290 (4) | 0.0438 (5) | 0.0412 (5) | 0.0088 (4) | 0.0157 (4) | 0.0111 (4) |
O12 | 0.0463 (5) | 0.0287 (4) | 0.0359 (5) | 0.0031 (4) | 0.0042 (4) | −0.0016 (4) |
O14 | 0.0514 (6) | 0.0577 (6) | 0.0395 (5) | 0.0122 (5) | 0.0050 (4) | 0.0268 (5) |
N2 | 0.0310 (5) | 0.0559 (7) | 0.0302 (5) | 0.0133 (5) | 0.0110 (4) | 0.0182 (5) |
N3 | 0.0309 (5) | 0.0362 (5) | 0.0250 (5) | 0.0068 (4) | 0.0111 (4) | 0.0102 (4) |
C2 | 0.0304 (5) | 0.0259 (5) | 0.0243 (5) | 0.0051 (4) | 0.0094 (4) | 0.0068 (4) |
C4 | 0.0281 (5) | 0.0231 (5) | 0.0278 (5) | 0.0026 (4) | 0.0107 (4) | 0.0047 (4) |
C5 | 0.0270 (5) | 0.0239 (5) | 0.0245 (5) | 0.0051 (4) | 0.0077 (4) | 0.0047 (4) |
C6 | 0.0234 (5) | 0.0250 (5) | 0.0299 (5) | 0.0057 (4) | 0.0094 (4) | 0.0082 (4) |
C7 | 0.0250 (5) | 0.0311 (6) | 0.0321 (6) | 0.0065 (4) | 0.0088 (4) | 0.0100 (5) |
C8 | 0.0274 (6) | 0.0443 (7) | 0.0382 (6) | 0.0110 (5) | 0.0111 (5) | 0.0198 (5) |
C9 | 0.0356 (6) | 0.0367 (7) | 0.0569 (8) | 0.0126 (5) | 0.0178 (6) | 0.0261 (6) |
C10 | 0.0350 (6) | 0.0246 (6) | 0.0564 (8) | 0.0061 (5) | 0.0161 (6) | 0.0107 (5) |
C11 | 0.0268 (5) | 0.0273 (5) | 0.0373 (6) | 0.0051 (4) | 0.0102 (5) | 0.0057 (5) |
C13 | 0.0547 (9) | 0.0348 (7) | 0.0569 (10) | 0.0022 (7) | 0.0079 (8) | −0.0118 (7) |
C15 | 0.0536 (10) | 0.0758 (12) | 0.0562 (10) | 0.0195 (9) | 0.0121 (8) | 0.0443 (9) |
Geometric parameters (Å, º) top
S1—C2 | 1.7488 (11) | C8—O14 | 1.3741 (16) |
S1—C5 | 1.8185 (11) | C8—C9 | 1.379 (2) |
C2—N2 | 1.3134 (16) | C9—C10 | 1.388 (2) |
C2—N3 | 1.3270 (15) | C9—H9 | 0.928 (18) |
N3—C4 | 1.3671 (15) | C10—C11 | 1.3871 (17) |
C4—O4 | 1.2211 (14) | C10—H10 | 0.956 (18) |
C4—C5 | 1.5462 (15) | C11—O12 | 1.3697 (16) |
C5—C6 | 1.5051 (15) | O12—C13 | 1.4350 (16) |
C5—H5 | 0.986 (14) | C13—H13A | 0.99 (2) |
N2—H2A | 0.905 (19) | C13—H13B | 0.99 (2) |
N2—H2B | 0.860 (18) | C13—H13C | 0.98 (2) |
C6—C7 | 1.3863 (16) | O14—C15 | 1.4264 (18) |
C6—C11 | 1.4042 (16) | C15—H15A | 0.99 (2) |
C7—C8 | 1.3937 (17) | C15—H15B | 0.98 (2) |
C7—H7 | 0.952 (15) | C15—H15C | 0.99 (2) |
| | | |
C2—S1—C5 | 90.41 (5) | C9—C8—C7 | 119.40 (12) |
N2—C2—N3 | 123.15 (11) | C8—C9—C10 | 120.16 (12) |
N2—C2—S1 | 119.43 (9) | C8—C9—H9 | 120.1 (11) |
N3—C2—S1 | 117.41 (9) | C10—C9—H9 | 119.7 (11) |
C2—N3—C4 | 112.25 (9) | C11—C10—C9 | 120.84 (12) |
O4—C4—N3 | 124.39 (10) | C11—C10—H10 | 119.4 (10) |
O4—C4—C5 | 120.63 (10) | C9—C10—H10 | 119.7 (10) |
N3—C4—C5 | 114.90 (9) | O12—C11—C10 | 125.04 (11) |
C6—C5—C4 | 117.84 (9) | O12—C11—C6 | 115.68 (10) |
C6—C5—S1 | 112.49 (7) | C10—C11—C6 | 119.28 (12) |
C4—C5—S1 | 104.59 (7) | C11—O12—C13 | 117.02 (12) |
C6—C5—H5 | 109.3 (8) | O12—C13—H13A | 109.6 (12) |
C4—C5—H5 | 105.4 (8) | O12—C13—H13B | 108.8 (12) |
S1—C5—H5 | 106.4 (8) | H13A—C13—H13B | 111.4 (17) |
C2—N2—H2A | 118.1 (12) | O12—C13—H13C | 105.2 (13) |
C2—N2—H2B | 120.0 (11) | H13A—C13—H13C | 112.2 (17) |
H2A—N2—H2B | 121.8 (16) | H13B—C13—H13C | 109.3 (17) |
C7—C6—C11 | 119.27 (11) | C8—O14—C15 | 117.14 (13) |
C7—C6—C5 | 118.89 (10) | O14—C15—H15A | 104.3 (13) |
C11—C6—C5 | 121.68 (10) | O14—C15—H15B | 111.0 (11) |
C6—C7—C8 | 121.05 (11) | H15A—C15—H15B | 112.5 (17) |
C6—C7—H7 | 120.1 (9) | O14—C15—H15C | 112.4 (13) |
C8—C7—H7 | 118.9 (9) | H15A—C15—H15C | 108.3 (18) |
O14—C8—C9 | 125.16 (12) | H15B—C15—H15C | 108.4 (17) |
O14—C8—C7 | 115.44 (12) | | |
Hydrogen-bond geometry (Å, º) top
D—H···A | D—H | H···A | D···A | D—H···A |
N2—H2A···N3i | 0.905 (19) | 2.04 (2) | 2.9281 (15) | 165.3 (17) |
N2—H2B···O4ii | 0.860 (18) | 2.176 (19) | 3.0102 (15) | 163.1 (16) |
Symmetry codes: (i) −x+1, −y+1, −z+2; (ii) x+1, y, z. |
(II) ethyl 2-amino-5-(2,5-dimethoxyphenyl)-1,3-thiazole-4-carboxylate
top
Crystal data top
C14H16N2O4S | F(000) = 648 |
Mr = 308.35 | Dx = 1.358 Mg m−3 |
Monoclinic, P21 | Mo Kα radiation, λ = 0.71073 Å |
Hall symbol: P 2yb | Cell parameters from all reflections |
a = 8.1740 (5) Å | θ = 2.8–27.5° |
b = 22.8266 (12) Å | µ = 0.23 mm−1 |
c = 9.0300 (5) Å | T = 293 K |
β = 116.444 (1)° | Prismatic, colourless |
V = 1508.57 (15) Å3 | 0.40 × 0.40 × 0.30 mm |
Z = 4 | |
Data collection top
Nonius Kappa CCD diffractometer | 5468 reflections with I > 2σ(I) |
Radiation source: fine-focus sealed tube | Rint = 0.031 |
Graphite monochromator | θmax = 27.5°, θmin = 2.8° |
ϕ and ω scans | h = −10→10 |
6339 measured reflections | k = −29→23 |
6339 independent reflections | l = −11→11 |
Refinement top
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.053 | H-atom parameters constrained |
wR(F2) = 0.139 | w = 1/[σ2(Fo2) + (0.0772P)2 + 0.6156P] where P = (Fo2 + 2Fc2)/3 |
S = 1.04 | (Δ/σ)max = 0.001 |
6339 reflections | Δρmax = 0.83 e Å−3 |
385 parameters | Δρmin = −0.23 e Å−3 |
1 restraint | Absolute structure: Flack H D (1983), Acta Cryst. A39, 876-881 |
Primary atom site location: structure-invariant direct methods | Absolute structure parameter: 0.02 (8) |
Crystal data top
C14H16N2O4S | V = 1508.57 (15) Å3 |
Mr = 308.35 | Z = 4 |
Monoclinic, P21 | Mo Kα radiation |
a = 8.1740 (5) Å | µ = 0.23 mm−1 |
b = 22.8266 (12) Å | T = 293 K |
c = 9.0300 (5) Å | 0.40 × 0.40 × 0.30 mm |
β = 116.444 (1)° | |
Data collection top
Nonius Kappa CCD diffractometer | 5468 reflections with I > 2σ(I) |
6339 measured reflections | Rint = 0.031 |
6339 independent reflections | |
Refinement top
R[F2 > 2σ(F2)] = 0.053 | H-atom parameters constrained |
wR(F2) = 0.139 | Δρmax = 0.83 e Å−3 |
S = 1.04 | Δρmin = −0.23 e Å−3 |
6339 reflections | Absolute structure: Flack H D (1983), Acta Cryst. A39, 876-881 |
385 parameters | Absolute structure parameter: 0.02 (8) |
1 restraint | |
Special details top
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top | x | y | z | Uiso*/Ueq | |
S1A | 1.13783 (11) | −0.00152 (3) | −0.04470 (10) | 0.04194 (19) | |
C2A | 1.0425 (4) | 0.05598 (14) | −0.1861 (4) | 0.0397 (7) | |
N2A | 1.1069 (5) | 0.06959 (15) | −0.2937 (4) | 0.0593 (9) | |
H2A | 1.0611 | 0.0986 | −0.3604 | 0.071* | |
H2B | 1.1944 | 0.0494 | −0.2964 | 0.071* | |
N3A | 0.9104 (3) | 0.08360 (11) | −0.1714 (3) | 0.0376 (5) | |
C4A | 0.8840 (4) | 0.06114 (13) | −0.0416 (3) | 0.0335 (6) | |
C5A | 0.9910 (4) | 0.01458 (13) | 0.0420 (3) | 0.0323 (6) | |
C6A | 1.0072 (4) | −0.01893 (12) | 0.1880 (3) | 0.0332 (6) | |
C7A | 1.1627 (4) | −0.01171 (14) | 0.3369 (4) | 0.0375 (7) | |
H7A | 1.2538 | 0.0139 | 0.3424 | 0.045* | |
C8A | 1.1843 (5) | −0.04215 (16) | 0.4777 (4) | 0.0423 (8) | |
C9A | 1.0498 (5) | −0.08051 (17) | 0.4681 (4) | 0.0482 (8) | |
H9A | 1.0640 | −0.1011 | 0.5619 | 0.058* | |
C10A | 0.8941 (5) | −0.08886 (17) | 0.3214 (4) | 0.0450 (8) | |
H10A | 0.8051 | −0.1153 | 0.3163 | 0.054* | |
C11A | 0.8712 (4) | −0.05736 (14) | 0.1807 (4) | 0.0362 (6) | |
O12A | 0.7222 (3) | −0.06278 (11) | 0.0288 (3) | 0.0500 (6) | |
C13A | 0.5775 (5) | −0.0996 (2) | 0.0164 (5) | 0.0676 (12) | |
H13A | 0.6194 | −0.1394 | 0.0365 | 0.101* | |
H13B | 0.4780 | −0.0964 | −0.0925 | 0.101* | |
H13C | 0.5370 | −0.0880 | 0.0968 | 0.101* | |
O14A | 1.3304 (4) | −0.03468 (14) | 0.6318 (3) | 0.0621 (7) | |
C15A | 1.4820 (5) | −0.0023 (2) | 0.6411 (5) | 0.0573 (10) | |
H15A | 1.5210 | −0.0177 | 0.5631 | 0.086* | |
H15B | 1.5802 | −0.0052 | 0.7508 | 0.086* | |
H15C | 1.4478 | 0.0381 | 0.6156 | 0.086* | |
C17A | 0.7405 (4) | 0.08922 (14) | −0.0075 (4) | 0.0368 (6) | |
O18A | 0.6388 (4) | 0.12646 (13) | −0.0924 (4) | 0.0631 (7) | |
O19A | 0.7417 (3) | 0.06896 (11) | 0.1308 (3) | 0.0477 (6) | |
C20A | 0.6021 (4) | 0.09115 (16) | 0.1732 (4) | 0.0456 (8) | |
H20A | 0.4817 | 0.0854 | 0.0821 | 0.055* | |
H20B | 0.6199 | 0.1327 | 0.1983 | 0.055* | |
C21A | 0.6204 (6) | 0.0573 (2) | 0.3220 (5) | 0.0619 (10) | |
H21A | 0.5906 | 0.0169 | 0.2924 | 0.093* | |
H21B | 0.5386 | 0.0731 | 0.3618 | 0.093* | |
H21C | 0.7438 | 0.0601 | 0.4071 | 0.093* | |
S1B | 0.70083 (11) | 0.26178 (3) | 0.38645 (10) | 0.0451 (2) | |
C2B | 0.7944 (4) | 0.20365 (15) | 0.5258 (4) | 0.0420 (7) | |
N2B | 0.7292 (5) | 0.18978 (16) | 0.6345 (4) | 0.0608 (9) | |
H2C | 0.7724 | 0.1600 | 0.6987 | 0.073* | |
H2D | 0.6444 | 0.2107 | 0.6398 | 0.073* | |
N3B | 0.9218 (3) | 0.17508 (11) | 0.5079 (3) | 0.0377 (5) | |
C4B | 0.9503 (4) | 0.19837 (13) | 0.3795 (3) | 0.0332 (6) | |
C5B | 0.8457 (4) | 0.24461 (13) | 0.2981 (4) | 0.0345 (6) | |
C6B | 0.8284 (4) | 0.27817 (12) | 0.1507 (3) | 0.0333 (6) | |
C7B | 0.6754 (4) | 0.26925 (14) | 0.0022 (4) | 0.0370 (7) | |
H7B | 0.5846 | 0.2436 | −0.0031 | 0.044* | |
C8B | 0.6571 (4) | 0.29882 (14) | −0.1404 (4) | 0.0381 (7) | |
C9B | 0.7933 (5) | 0.33668 (15) | −0.1306 (4) | 0.0452 (7) | |
H9B | 0.7821 | 0.3563 | −0.2249 | 0.054* | |
C10B | 0.9455 (5) | 0.34567 (15) | 0.0174 (4) | 0.0445 (7) | |
H10B | 1.0364 | 0.3712 | 0.0220 | 0.053* | |
C11B | 0.9646 (4) | 0.31690 (15) | 0.1606 (4) | 0.0374 (7) | |
O12B | 1.1103 (3) | 0.32378 (11) | 0.3123 (3) | 0.0516 (6) | |
C13B | 1.2519 (6) | 0.3615 (3) | 0.3255 (5) | 0.0717 (13) | |
H13D | 1.3011 | 0.3485 | 0.2525 | 0.108* | |
H13E | 1.3464 | 0.3613 | 0.4373 | 0.108* | |
H13F | 1.2048 | 0.4006 | 0.2959 | 0.108* | |
O14B | 0.5110 (3) | 0.29203 (12) | −0.2930 (3) | 0.0545 (6) | |
C15B | 0.3604 (5) | 0.2577 (2) | −0.3027 (5) | 0.0569 (9) | |
H15D | 0.3967 | 0.2174 | −0.2808 | 0.085* | |
H15E | 0.2607 | 0.2612 | −0.4115 | 0.085* | |
H15F | 0.3224 | 0.2716 | −0.2225 | 0.085* | |
C17B | 1.0913 (4) | 0.16904 (14) | 0.3448 (4) | 0.0363 (6) | |
O18B | 1.1909 (4) | 0.13113 (12) | 0.4278 (3) | 0.0607 (7) | |
O19B | 1.0945 (3) | 0.19020 (11) | 0.2086 (3) | 0.0478 (6) | |
C20B | 1.2327 (4) | 0.16804 (16) | 0.1654 (4) | 0.0450 (7) | |
H20C | 1.2128 | 0.1267 | 0.1382 | 0.054* | |
H20D | 1.3530 | 0.1729 | 0.2573 | 0.054* | |
C21B | 1.2185 (6) | 0.20242 (19) | 0.0186 (5) | 0.0578 (10) | |
H21D | 1.0950 | 0.2010 | −0.0669 | 0.087* | |
H21E | 1.2989 | 0.1859 | −0.0218 | 0.087* | |
H21F | 1.2525 | 0.2424 | 0.0506 | 0.087* | |
Atomic displacement parameters (Å2) top | U11 | U22 | U33 | U12 | U13 | U23 |
S1A | 0.0478 (4) | 0.0416 (4) | 0.0462 (4) | 0.0106 (3) | 0.0298 (3) | 0.0115 (3) |
C2A | 0.0478 (16) | 0.0393 (17) | 0.0368 (15) | 0.0033 (13) | 0.0233 (13) | 0.0075 (12) |
N2A | 0.078 (2) | 0.062 (2) | 0.0621 (19) | 0.0233 (17) | 0.0528 (18) | 0.0252 (16) |
N3A | 0.0442 (13) | 0.0390 (14) | 0.0361 (12) | 0.0037 (11) | 0.0238 (11) | 0.0067 (10) |
C4A | 0.0351 (14) | 0.0357 (16) | 0.0323 (14) | −0.0016 (11) | 0.0173 (12) | 0.0031 (11) |
C5A | 0.0337 (13) | 0.0339 (16) | 0.0310 (13) | 0.0008 (11) | 0.0159 (11) | 0.0025 (11) |
C6A | 0.0387 (14) | 0.0300 (15) | 0.0362 (14) | 0.0045 (11) | 0.0215 (12) | 0.0042 (11) |
C7A | 0.0387 (14) | 0.0397 (18) | 0.0357 (14) | 0.0000 (13) | 0.0181 (12) | 0.0068 (12) |
C8A | 0.0440 (17) | 0.048 (2) | 0.0317 (15) | 0.0021 (14) | 0.0142 (13) | 0.0037 (13) |
C9A | 0.0559 (19) | 0.055 (2) | 0.0384 (16) | −0.0025 (16) | 0.0250 (15) | 0.0117 (14) |
C10A | 0.0520 (18) | 0.0430 (19) | 0.0453 (17) | −0.0083 (15) | 0.0264 (15) | 0.0082 (15) |
C11A | 0.0396 (14) | 0.0344 (16) | 0.0373 (15) | −0.0023 (12) | 0.0197 (12) | 0.0027 (12) |
O12A | 0.0461 (12) | 0.0540 (15) | 0.0448 (12) | −0.0159 (11) | 0.0157 (10) | 0.0051 (11) |
C13A | 0.050 (2) | 0.083 (3) | 0.059 (2) | −0.025 (2) | 0.0142 (18) | 0.015 (2) |
O14A | 0.0570 (15) | 0.085 (2) | 0.0337 (12) | −0.0096 (14) | 0.0106 (11) | 0.0116 (12) |
C15A | 0.0442 (18) | 0.074 (3) | 0.0437 (18) | −0.004 (2) | 0.0106 (15) | 0.0036 (19) |
C17A | 0.0391 (15) | 0.0364 (16) | 0.0392 (15) | 0.0014 (13) | 0.0215 (13) | 0.0041 (12) |
O18A | 0.0668 (16) | 0.0699 (18) | 0.0622 (16) | 0.0328 (14) | 0.0373 (13) | 0.0276 (14) |
O19A | 0.0474 (12) | 0.0585 (15) | 0.0505 (13) | 0.0174 (11) | 0.0338 (11) | 0.0161 (11) |
C20A | 0.0440 (16) | 0.048 (2) | 0.057 (2) | 0.0036 (14) | 0.0336 (15) | 0.0015 (15) |
C21A | 0.073 (2) | 0.069 (3) | 0.068 (2) | 0.001 (2) | 0.053 (2) | 0.0051 (19) |
S1B | 0.0524 (4) | 0.0455 (5) | 0.0489 (4) | 0.0143 (3) | 0.0328 (4) | 0.0140 (3) |
C2B | 0.0504 (17) | 0.0447 (18) | 0.0386 (16) | 0.0078 (14) | 0.0266 (14) | 0.0058 (13) |
N2B | 0.081 (2) | 0.064 (2) | 0.0633 (19) | 0.0268 (17) | 0.0559 (18) | 0.0272 (16) |
N3B | 0.0439 (13) | 0.0398 (14) | 0.0339 (12) | 0.0065 (11) | 0.0214 (11) | 0.0109 (10) |
C4B | 0.0354 (13) | 0.0336 (15) | 0.0318 (14) | 0.0007 (11) | 0.0161 (11) | 0.0045 (11) |
C5B | 0.0356 (14) | 0.0355 (16) | 0.0358 (15) | 0.0008 (11) | 0.0189 (12) | 0.0040 (11) |
C6B | 0.0379 (14) | 0.0328 (16) | 0.0319 (14) | 0.0027 (11) | 0.0181 (12) | 0.0079 (11) |
C7B | 0.0380 (15) | 0.0348 (17) | 0.0397 (16) | 0.0001 (13) | 0.0185 (13) | 0.0041 (13) |
C8B | 0.0440 (15) | 0.0386 (17) | 0.0328 (14) | 0.0054 (13) | 0.0180 (12) | 0.0064 (12) |
C9B | 0.0547 (18) | 0.0429 (18) | 0.0425 (17) | 0.0046 (14) | 0.0258 (15) | 0.0141 (13) |
C10B | 0.0496 (17) | 0.0381 (18) | 0.0490 (18) | −0.0041 (14) | 0.0249 (15) | 0.0101 (14) |
C11B | 0.0392 (15) | 0.0369 (17) | 0.0367 (15) | 0.0009 (13) | 0.0175 (13) | 0.0030 (12) |
O12B | 0.0454 (12) | 0.0596 (16) | 0.0410 (12) | −0.0128 (11) | 0.0111 (10) | 0.0087 (11) |
C13B | 0.055 (2) | 0.086 (3) | 0.059 (2) | −0.028 (2) | 0.012 (2) | 0.006 (2) |
O14B | 0.0513 (13) | 0.0683 (17) | 0.0353 (12) | −0.0068 (12) | 0.0116 (10) | 0.0108 (11) |
C15B | 0.0515 (19) | 0.064 (2) | 0.0428 (18) | −0.0089 (18) | 0.0093 (15) | 0.0013 (17) |
C17B | 0.0357 (14) | 0.0396 (17) | 0.0337 (14) | 0.0020 (13) | 0.0154 (12) | 0.0039 (12) |
O18B | 0.0707 (16) | 0.0624 (17) | 0.0612 (16) | 0.0299 (14) | 0.0403 (14) | 0.0250 (14) |
O19B | 0.0511 (13) | 0.0554 (15) | 0.0517 (13) | 0.0164 (11) | 0.0363 (11) | 0.0173 (11) |
C20B | 0.0447 (16) | 0.048 (2) | 0.0540 (19) | 0.0034 (14) | 0.0327 (15) | 0.0012 (15) |
C21B | 0.067 (2) | 0.062 (2) | 0.065 (2) | 0.0026 (18) | 0.048 (2) | 0.0077 (18) |
Geometric parameters (Å, º) top
S1A—C5A | 1.739 (3) | S1B—C5B | 1.742 (3) |
S1A—C2A | 1.753 (3) | S1B—C2B | 1.753 (3) |
C2A—N3A | 1.307 (4) | C2B—N3B | 1.298 (4) |
C2A—N2A | 1.332 (4) | C2B—N2B | 1.347 (4) |
N2A—H2A | 0.8600 | N2B—H2C | 0.8600 |
N2A—H2B | 0.8600 | N2B—H2D | 0.8600 |
N3A—C4A | 1.381 (4) | N3B—C4B | 1.386 (4) |
C4A—C5A | 1.370 (4) | C4B—C5B | 1.351 (4) |
C4A—C17A | 1.484 (4) | C4B—C17B | 1.482 (4) |
C5A—C6A | 1.478 (4) | C5B—C6B | 1.487 (4) |
C6A—C7A | 1.388 (4) | C6B—C7B | 1.382 (4) |
C6A—C11A | 1.394 (4) | C6B—C11B | 1.393 (4) |
C7A—C8A | 1.390 (4) | C7B—C8B | 1.401 (4) |
C7A—H7A | 0.9300 | C7B—H7B | 0.9300 |
C8A—C9A | 1.377 (5) | C8B—O14B | 1.373 (4) |
C8A—O14A | 1.382 (4) | C8B—C9B | 1.381 (5) |
C9A—C10A | 1.382 (5) | C9B—C10B | 1.376 (5) |
C9A—H9A | 0.9300 | C9B—H9B | 0.9300 |
C10A—C11A | 1.398 (4) | C10B—C11B | 1.395 (4) |
C10A—H10A | 0.9300 | C10B—H10B | 0.9300 |
C11A—O12A | 1.376 (4) | C11B—O12B | 1.366 (4) |
O12A—C13A | 1.414 (4) | O12B—C13B | 1.405 (5) |
C13A—H13A | 0.9600 | C13B—H13D | 0.9600 |
C13A—H13B | 0.9600 | C13B—H13E | 0.9600 |
C13A—H13C | 0.9600 | C13B—H13F | 0.9600 |
O14A—C15A | 1.413 (5) | O14B—C15B | 1.428 (5) |
C15A—H15A | 0.9600 | C15B—H15D | 0.9600 |
C15A—H15B | 0.9600 | C15B—H15E | 0.9600 |
C15A—H15C | 0.9600 | C15B—H15F | 0.9600 |
C17A—O18A | 1.198 (4) | C17B—O18B | 1.196 (4) |
C17A—O19A | 1.328 (4) | C17B—O19B | 1.332 (4) |
O19A—C20A | 1.447 (4) | O19B—C20B | 1.441 (4) |
C20A—C21A | 1.498 (5) | C20B—C21B | 1.499 (5) |
C20A—H20A | 0.9700 | C20B—H20C | 0.9700 |
C20A—H20B | 0.9700 | C20B—H20D | 0.9700 |
C21A—H21A | 0.9600 | C21B—H21D | 0.9600 |
C21A—H21B | 0.9600 | C21B—H21E | 0.9600 |
C21A—H21C | 0.9600 | C21B—H21F | 0.9600 |
| | | |
C5A—S1A—C2A | 89.86 (14) | C5B—S1B—C2B | 89.43 (14) |
N3A—C2A—N2A | 125.1 (3) | N3B—C2B—N2B | 124.9 (3) |
N3A—C2A—S1A | 114.0 (2) | N3B—C2B—S1B | 114.1 (2) |
N2A—C2A—S1A | 120.9 (3) | N2B—C2B—S1B | 120.9 (3) |
C2A—N2A—H2A | 120.0 | C2B—N2B—H2C | 120.0 |
C2A—N2A—H2B | 120.0 | C2B—N2B—H2D | 120.0 |
H2A—N2A—H2B | 120.0 | H2C—N2B—H2D | 120.0 |
C2A—N3A—C4A | 110.8 (3) | C2B—N3B—C4B | 110.8 (3) |
C5A—C4A—N3A | 116.9 (3) | C5B—C4B—N3B | 117.0 (3) |
C5A—C4A—C17A | 126.2 (3) | C5B—C4B—C17B | 126.9 (3) |
N3A—C4A—C17A | 116.9 (3) | N3B—C4B—C17B | 116.1 (3) |
C4A—C5A—C6A | 132.4 (3) | C4B—C5B—C6B | 132.4 (3) |
C4A—C5A—S1A | 108.3 (2) | C4B—C5B—S1B | 108.7 (2) |
C6A—C5A—S1A | 119.1 (2) | C6B—C5B—S1B | 118.8 (2) |
C7A—C6A—C11A | 119.2 (3) | C7B—C6B—C11B | 120.5 (3) |
C7A—C6A—C5A | 118.8 (3) | C7B—C6B—C5B | 118.5 (3) |
C11A—C6A—C5A | 122.0 (3) | C11B—C6B—C5B | 121.0 (3) |
C6A—C7A—C8A | 121.0 (3) | C6B—C7B—C8B | 120.0 (3) |
C6A—C7A—H7A | 119.5 | C6B—C7B—H7B | 120.0 |
C8A—C7A—H7A | 119.5 | C8B—C7B—H7B | 120.0 |
C9A—C8A—O14A | 116.7 (3) | O14B—C8B—C9B | 116.8 (3) |
C9A—C8A—C7A | 119.2 (3) | O14B—C8B—C7B | 123.9 (3) |
O14A—C8A—C7A | 124.1 (3) | C9B—C8B—C7B | 119.3 (3) |
C8A—C9A—C10A | 121.1 (3) | C10B—C9B—C8B | 120.6 (3) |
C8A—C9A—H9A | 119.5 | C10B—C9B—H9B | 119.7 |
C10A—C9A—H9A | 119.5 | C8B—C9B—H9B | 119.7 |
C9A—C10A—C11A | 119.6 (3) | C9B—C10B—C11B | 120.6 (3) |
C9A—C10A—H10A | 120.2 | C9B—C10B—H10B | 119.7 |
C11A—C10A—H10A | 120.2 | C11B—C10B—H10B | 119.7 |
O12A—C11A—C6A | 115.9 (3) | O12B—C11B—C6B | 116.9 (3) |
O12A—C11A—C10A | 124.1 (3) | O12B—C11B—C10B | 124.3 (3) |
C6A—C11A—C10A | 119.9 (3) | C6B—C11B—C10B | 118.9 (3) |
C11A—O12A—C13A | 118.0 (3) | C11B—O12B—C13B | 118.2 (3) |
O12A—C13A—H13A | 109.5 | O12B—C13B—H13D | 109.5 |
O12A—C13A—H13B | 109.5 | O12B—C13B—H13E | 109.5 |
H13A—C13A—H13B | 109.5 | H13D—C13B—H13E | 109.5 |
O12A—C13A—H13C | 109.5 | O12B—C13B—H13F | 109.5 |
H13A—C13A—H13C | 109.5 | H13D—C13B—H13F | 109.5 |
H13B—C13A—H13C | 109.5 | H13E—C13B—H13F | 109.5 |
C8A—O14A—C15A | 117.8 (3) | C8B—O14B—C15B | 117.7 (3) |
O14A—C15A—H15A | 109.5 | O14B—C15B—H15D | 109.5 |
O14A—C15A—H15B | 109.5 | O14B—C15B—H15E | 109.5 |
H15A—C15A—H15B | 109.5 | H15D—C15B—H15E | 109.5 |
O14A—C15A—H15C | 109.5 | O14B—C15B—H15F | 109.5 |
H15A—C15A—H15C | 109.5 | H15D—C15B—H15F | 109.5 |
H15B—C15A—H15C | 109.5 | H15E—C15B—H15F | 109.5 |
O18A—C17A—O19A | 124.2 (3) | O18B—C17B—O19B | 123.6 (3) |
O18A—C17A—C4A | 124.1 (3) | O18B—C17B—C4B | 124.8 (3) |
O19A—C17A—C4A | 111.7 (3) | O19B—C17B—C4B | 111.6 (2) |
C17A—O19A—C20A | 116.8 (3) | C17B—O19B—C20B | 117.5 (3) |
O19A—C20A—C21A | 106.3 (3) | O19B—C20B—C21B | 107.1 (3) |
O19A—C20A—H20A | 110.5 | O19B—C20B—H20C | 110.3 |
C21A—C20A—H20A | 110.5 | C21B—C20B—H20C | 110.3 |
O19A—C20A—H20B | 110.5 | O19B—C20B—H20D | 110.3 |
C21A—C20A—H20B | 110.5 | C21B—C20B—H20D | 110.3 |
H20A—C20A—H20B | 108.7 | H20C—C20B—H20D | 108.5 |
C20A—C21A—H21A | 109.5 | C20B—C21B—H21D | 109.5 |
C20A—C21A—H21B | 109.5 | C20B—C21B—H21E | 109.5 |
H21A—C21A—H21B | 109.5 | H21D—C21B—H21E | 109.5 |
C20A—C21A—H21C | 109.5 | C20B—C21B—H21F | 109.5 |
H21A—C21A—H21C | 109.5 | H21D—C21B—H21F | 109.5 |
H21B—C21A—H21C | 109.5 | H21E—C21B—H21F | 109.5 |
Hydrogen-bond geometry (Å, º) top
D—H···A | D—H | H···A | D···A | D—H···A |
N2A—H2A···N3Bi | 0.86 | 2.13 | 2.980 (4) | 168 |
N2A—H2B···O14Ai | 0.86 | 2.45 | 3.248 (4) | 156 |
N2B—H2C···N3Aii | 0.86 | 2.12 | 2.971 (4) | 168 |
N2B—H2D···O14Bii | 0.86 | 2.37 | 3.178 (4) | 158 |
Symmetry codes: (i) x, y, z−1; (ii) x, y, z+1. |
Experimental details
| (I) | (II) |
Crystal data |
Chemical formula | C11H12N2O3S | C14H16N2O4S |
Mr | 252.29 | 308.35 |
Crystal system, space group | Triclinic, P1 | Monoclinic, P21 |
Temperature (K) | 293 | 293 |
a, b, c (Å) | 6.9572 (5), 8.1499 (7), 10.4564 (10) | 8.1740 (5), 22.8266 (12), 9.0300 (5) |
α, β, γ (°) | 99.800 (2), 101.050 (2), 99.540 (2) | 90, 116.444 (1), 90 |
V (Å3) | 561.21 (8) | 1508.57 (15) |
Z | 2 | 4 |
Radiation type | Mo Kα | Mo Kα |
µ (mm−1) | 0.29 | 0.23 |
Crystal size (mm) | 0.40 × 0.35 × 0.30 | 0.40 × 0.40 × 0.30 |
|
Data collection |
Diffractometer | Nonius KappaCCD diffractometer | Nonius Kappa CCD diffractometer |
Absorption correction | – | – |
No. of measured, independent and observed [I > 2σ(I)] reflections | 3846, 2490, 2349 | 6339, 6339, 5468 |
Rint | 0.014 | 0.031 |
(sin θ/λ)max (Å−1) | 0.649 | 0.649 |
|
Refinement |
R[F2 > 2σ(F2)], wR(F2), S | 0.029, 0.078, 1.05 | 0.053, 0.139, 1.04 |
No. of reflections | 2490 | 6339 |
No. of parameters | 202 | 385 |
No. of restraints | 0 | 1 |
H-atom treatment | All H-atom parameters refined | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.27, −0.22 | 0.83, −0.23 |
Absolute structure | ? | Flack H D (1983), Acta Cryst. A39, 876-881 |
Absolute structure parameter | ? | 0.02 (8) |
Selected geometric parameters (Å, º) for (I) topS1—C2 | 1.7488 (11) | C6—C11 | 1.4042 (16) |
S1—C5 | 1.8185 (11) | C7—C8 | 1.3937 (17) |
C2—N2 | 1.3134 (16) | C8—O14 | 1.3741 (16) |
C2—N3 | 1.3270 (15) | C8—C9 | 1.379 (2) |
N3—C4 | 1.3671 (15) | C9—C10 | 1.388 (2) |
C4—O4 | 1.2211 (14) | C10—C11 | 1.3871 (17) |
C4—C5 | 1.5462 (15) | C11—O12 | 1.3697 (16) |
C5—C6 | 1.5051 (15) | O12—C13 | 1.4350 (16) |
C6—C7 | 1.3863 (16) | O14—C15 | 1.4264 (18) |
| | | |
C2—S1—C5 | 90.41 (5) | C7—C6—C5 | 118.89 (10) |
N2—C2—N3 | 123.15 (11) | C11—C6—C5 | 121.68 (10) |
N2—C2—S1 | 119.43 (9) | C6—C7—C8 | 121.05 (11) |
N3—C2—S1 | 117.41 (9) | O14—C8—C9 | 125.16 (12) |
C2—N3—C4 | 112.25 (9) | O14—C8—C7 | 115.44 (12) |
O4—C4—N3 | 124.39 (10) | C9—C8—C7 | 119.40 (12) |
O4—C4—C5 | 120.63 (10) | C8—C9—C10 | 120.16 (12) |
N3—C4—C5 | 114.90 (9) | C11—C10—C9 | 120.84 (12) |
C6—C5—C4 | 117.84 (9) | O12—C11—C10 | 125.04 (11) |
C6—C5—S1 | 112.49 (7) | O12—C11—C6 | 115.68 (10) |
C4—C5—S1 | 104.59 (7) | C10—C11—C6 | 119.28 (12) |
C7—C6—C11 | 119.27 (11) | C11—O12—C13 | 117.02 (12) |
Hydrogen-bond geometry (Å, º) for (I) top
D—H···A | D—H | H···A | D···A | D—H···A |
N2—H2A···N3i | 0.905 (19) | 2.04 (2) | 2.9281 (15) | 165.3 (17) |
N2—H2B···O4ii | 0.860 (18) | 2.176 (19) | 3.0102 (15) | 163.1 (16) |
Symmetry codes: (i) −x+1, −y+1, −z+2; (ii) x+1, y, z. |
Selected bond lengths (Å) for (II) topS1A—C5A | 1.739 (3) | S1B—C5B | 1.742 (3) |
S1A—C2A | 1.753 (3) | S1B—C2B | 1.753 (3) |
C2A—N3A | 1.307 (4) | C2B—N3B | 1.298 (4) |
C2A—N2A | 1.332 (4) | C2B—N2B | 1.347 (4) |
N3A—C4A | 1.381 (4) | N3B—C4B | 1.386 (4) |
C4A—C5A | 1.370 (4) | C4B—C5B | 1.351 (4) |
C4A—C17A | 1.484 (4) | C4B—C17B | 1.482 (4) |
C5A—C6A | 1.478 (4) | C5B—C6B | 1.487 (4) |
C6A—C7A | 1.388 (4) | C6B—C7B | 1.382 (4) |
C6A—C11A | 1.394 (4) | C6B—C11B | 1.393 (4) |
C7A—C8A | 1.390 (4) | C7B—C8B | 1.401 (4) |
C8A—C9A | 1.377 (5) | C8B—O14B | 1.373 (4) |
C8A—O14A | 1.382 (4) | C8B—C9B | 1.381 (5) |
C9A—C10A | 1.382 (5) | C9B—C10B | 1.376 (5) |
C10A—C11A | 1.398 (4) | C10B—C11B | 1.395 (4) |
C11A—O12A | 1.376 (4) | C11B—O12B | 1.366 (4) |
O12A—C13A | 1.414 (4) | O12B—C13B | 1.405 (5) |
O14A—C15A | 1.413 (5) | O14B—C15B | 1.428 (5) |
C17A—O18A | 1.198 (4) | C17B—O18B | 1.196 (4) |
C17A—O19A | 1.328 (4) | C17B—O19B | 1.332 (4) |
O19A—C20A | 1.447 (4) | O19B—C20B | 1.441 (4) |
C20A—C21A | 1.498 (5) | C20B—C21B | 1.499 (5) |
Hydrogen-bond geometry (Å, º) for (II) top
D—H···A | D—H | H···A | D···A | D—H···A |
N2A—H2A···N3Bi | 0.86 | 2.13 | 2.980 (4) | 167.8 |
N2A—H2B···O14Ai | 0.86 | 2.45 | 3.248 (4) | 155.5 |
N2B—H2C···N3Aii | 0.86 | 2.12 | 2.971 (4) | 168.0 |
N2B—H2D···O14Bii | 0.86 | 2.37 | 3.178 (4) | 157.6 |
Symmetry codes: (i) x, y, z−1; (ii) x, y, z+1. |
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Many naturally occurring and synthetic thiazole derivatives exhibit biological activities, such as antibiotic, anti-inflammatory, anthelmintic or fungicide properties (Metzger, 1984; Crews et al., 1988; Shinagawa et al., 1997; Shivarama Holla et al., 2003). The 1,3-thiazole ring can be prepared using several different methods (Metzger, 1984), although the most widely used approach relies on the synthesis described by Hantzsch (1887), which starts from α-halocarbonyl derivatives. This method can be modified by the replacement of α-halocarbonyl derivatives with 2-cyanooxiranes reacting as synthetic equivalents of the ketene dication (Robert et al., 1995, and references therein). We focus our attention here on the synthesis of thiazole and thiazoline derivatives from 2,2-dicyanooxirane and 2-cyano-2-oxiranecarboxylate derivatives. On addition of thiourea, on one hand, geminal dicyano oxirane derivatives were transformed into 2-aminothiazolinones, and on the other hand, ethyl 2-cyano-2-oxiranecarboxylate yielded 2-aminothiazols. In this paper we present the synthesis and structure of 2-amino-5-(2,5-dimethoxyphenyl)-4,5-dihydro-1,3-thiazol-4-one, (I), and ethyl 2-amino-5-(2,5-dimethoxyphenyl)-1,3-thiazole-4-carboxylate, (II). To the best of our knowledge, this is the first report of the crystal structure of the 2-aminothiazole derivative.
The molecular structure of (I) is shown in Fig. 1. The heterocyclic (thiazole) ring is close to perfectly planar, and the angle between the least-square planes of the phenyl and thiazole rings is 86.46 (4)°. Other geometric parameters are listed in Table 1. The two types of hydrogen-bonding interaction are illustrated in Fig. 2. The first involves N—H···N bonds between the amino group and the endocyclic thiazole N atom of two molecules symmetry-related by an inversion centre. These dimers are further connected into chains along the a axis via N—H···O interactions with adjacent dimeric units. For hydrogen-bonding details see Table 2.
X-ray analysis of (II) reveals that the crystals consist of two crystallographically independent molecules (A and B) related by a local pseudo-inversion centre. The atomic labeling schemes for these two molecules include the letter corresponding to the independent molecule (Fig. 3). The two independent mirror-related molecules have similar conformations (Fig. 4), and there are no significant differences in bond lengths and angles for molecules A and B (Table 3). The angles between the planes of dimethoxyphenyl ring and the thiazole ring are 69.32 (12) and 71.44 (12)° in molecules A and B, respectively. As in (I), two types of intermolecular hydrogen bond are present. Amino groups of both molecules are involved in an interaction with the endocyclic N atom and in the formation of an N—H···O bond with a neighbouring molecule. While in compound (I), the carbonyl O atom of the thiazolinone ring acts as a hydrogen-bond acceptor, in compound (II), one of the methoxy groups on both substituted phenyl rings serves as a hydrogen-bond acceptor. For hydrogen bonding details see Table 4.