(-)-Tetrahydropalmatine Monohydrate

The title compound, C₂₁H₂₅NO₄.H₂O, was isolated from the rhizome of Stefania rotunda L. of Vietnam and its structure elucidated. An S configuration was found at the asymmetric C13 atom of the (-)-enantiomer. The water molecule generates endless helically arranged molecular columns around the screw axes in the z direction through intermolecular hydrogen bonds.

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