Four N-Benzyl-Substituted 2-Ethyl-3-hydroxypyridin-4-ones

The molecular structures of 1-benzyl-2-ethyl-3-hydroxypyridin-4-one hydrate [(1), C₁₄H₁₅NO₂.H₂O], 2-ethyl-3-hydroxy-1-(4-methylbenzyl)pyridin-4-one [(2), C₁₅H₁₇NO₂], 2-ethyl-1-(4-fluorobenzyl)-3-hydroxypyridin-4-one [(3), C₁₄H₁₄FNO₂] and 2-ethyl-3-hydroxy-1-(4-trifluoromethylbenzyl)pyridin-4-one hemihydrate [(4), C₁₅H₁₄F₃NO₂.0.5H₂O] have been determined. The compounds all exhibit mutually hydrogen-bonded dimeric pairs. In the case of (1) and (2), the molecules of the dimer are symmetry related, while in (3) and (4), two independent molecules of the asymmetric unit are linked. For the hydrates (1) and (4), the dimeric pairs are linked by further hydrogen bonds through the water molecules.

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