4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide N-Oxide Hydrate (Loperamide N-Oxide Hydrate)

The crystal structure of the title compound, C₂₉H₃₃ClN₂O₃.2.25H₂O, has been determined. The three C-N(piperidyl) bond lengths reflect the tetracovalency of the piperidine N atom. A strong intermolecular hydrogen bond between the hydroxyl and the N-oxide of neighbouring molecules forms endless chains in the b direction of the C2/c space group. The positions of the water molecules are partially occupied.

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