Structure of the laccase from Coprinus cinereus at 1.68 Å resolution: evidence for different `type 2 Cu-­depleted' isoforms

Laccases (E.C. 1.10.3.2; benzenediol oxygen oxidoreductases) couple the four-electron reduction of dioxygen to water to four one-electron oxidations of a reducing substrate. The three-dimensional structure of the `blue' multi-copper oxidase laccase from the fungus Coprinus cinereus at 1.68 Å reveals the structural basis for isoforms of the type 2 Cu-­depleted species.