research communications\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 71| Part 11| November 2015| Pages 1270-1277
https://doi.org/10.1107/S2056989015017958

A comparison of the structures of some 2- and 3-substituted chromone derivatives: a structural study on the importance of the secondary carboxamide backbone for the inhibitory activity of MAO-B

Ligia R. Gomes,a,b John Nicolson Low,c* Fernando Cagide,d Alexandra Gaspard and Fernanda Borgesd

aFP-ENAS-Faculdade de Ciências de Saúde, Escola Superior de Saúde da UFP, Universidade Fernando Pessoa, Rua Carlos da Maia, 296, P-4200-150 Porto, Portugal, bREQUIMTE/Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal, cDepartment of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen, AB24 3UE, Scotland, and dCIQUP/Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal
*Correspondence e-mail: jnlow111@gmail.com

Edited by A. J. Lough, University of Toronto, Canada (Received 19 September 2015; accepted 25 September 2015; online 3 October 2015)

The crystal structures of the 3-substituted tertiary chromone carboxamide derivative, C17H13NO3, N-methyl-4-oxo-N-phenyl-4H-chromene-3-carboxamide (1), and the chromone carbonyl pyrrolidine derivatives, C14H13NO3, 3-(pyrrolidine-1-carbon­yl)-4H-chromen-4-one (3) and 2-(pyrrolidine-1-carbon­yl)-4H-chromen-4-one (4) have been determined. Their structural features are discussed and compared with similar compounds namely with respect to their MAO-B inhibitory activities. The chromone carboxamide presents a –syn conformation with the aromatic rings twisted with respect to each other [the dihedral angle between the mean planes of the chromone system and the exocyclic phenyl ring is 58.48 (8)°]. The pyrrolidine derivatives also display a significant twist: the dihedral angles between the chromone system and the best plane formed by the pyrrolidine atoms are 48.9 (2) and 23.97 (12)° in (3) and (4), respectively. Compound (3) shows a short C—H⋯O intra­molecular contact forming an S(7) ring. The supra­molecular structures for each compound are defined by weak C—H⋯O hydrogen bonds, which link the mol­ecules into chains and sheets. The Cambridge Structural Database gave 45 hits for compounds with a pyrrolidinecarbonyl group. A simple statistical analysis of their geometric parameters is made in order to compare them with those of the mol­ecules determined in the present work.

CCDC references: 1427459; 1427458; 1025355

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1. Chemical context

Chromone (1-benzo­pyran-4-one) is the building block of a large family of natural and synthetic compounds of the utmost importance in medicinal chemistry (Gaspar et al., 2014[Gaspar, A., Matos, M. J., Garrido, J., Uriarte, E. & Borges, F. (2014). Chem. Rev. 114, 4960-4992.]). Within this group of heterocycles, chromone carboxamide derivatives have been found to display inter­esting biological activities, namely as adenosine receptor ligands (Gaspar et al., 2012[Gaspar, A., Reis, J., Kachler, S., Paoletta, S., Uriarte, E., Klotz, K. N., Moro, S. & Borges, F. (2012). Biochem. Pharmacol. 84, 21-29.]) and as MAO-B inhibitors (Gaspar et al., 2012[Gaspar, A., Reis, J., Kachler, S., Paoletta, S., Uriarte, E., Klotz, K. N., Moro, S. & Borges, F. (2012). Biochem. Pharmacol. 84, 21-29.]; Gomes et al., 2015b[Gomes, L. R., Low, J. N., Cagide, F., Chavarria, D. & Borges, F. (2015b). Acta Cryst. E71, 547-554.]; Cagide et al., 2015[Cagide, F., Silva, T., Reis, J., Gaspar, A., Borges, F., Gomes, L. R. & Low, J. N. (2015). Chem. Commun. 51, 2832-2835.]). From the library synthesized so far, chromones (1)–(6) were selected for the present study, see Scheme. Previous data acquired on the development of new MAO-B inhibitors allowed us to conclude that 2-substituted chromones carboxamides based on the N-phenyl-4-oxo-4H-2-chromone carboxamide (6) skeleton have no significant IMAO-B activity whereas 3-substituted carboxamides based on the N-phenyl-4-oxo-4H-3-chromone carboxamide (5) core have been shown to be potent and selective inhibitors (Cagide et al., 2015[Cagide, F., Silva, T., Reis, J., Gaspar, A., Borges, F., Gomes, L. R. & Low, J. N. (2015). Chem. Commun. 51, 2832-2835.]). Structure–activity relationship (SAR) studies revealed the significance of phenyl­carboxamide as a key structure. Structural investigations made so far show that the derivatives of (5) have very similar conformations and indicate that the displayed IMAO-B activity is mostly dependent on electronic factors modulated by the nature and position of the substituent group attached to the exocyclic phenyl substituent (Gomes et al., 2015a[Gomes, L. R., Low, J. N., Cagide, F. & Borges, F. (2015a). Acta Cryst. E71, 88-93.],b[Gomes, L. R., Low, J. N., Cagide, F., Chavarria, D. & Borges, F. (2015b). Acta Cryst. E71, 547-554.]). Despite this, those studies do not allow inferences to be made about (i) the importance of the carboxamide group, including the amidic hydrogen atom or (ii) the configuration of the amide due to the C–N rotamer, in the mol­ecular docking. Thus new compounds were synthesised and structurally characterized viz. N-methyl-4-oxo-N-phenyl-4H-chromene-3-carboxamide (1) and its isomer N-methyl-4-oxo-N-phenyl-4H-chromene-2-carboxamide (2), both tertiary carboxamides, as opposed to the secondary carboxamides (5) and (6) and 3-(pyrrolidine-1-carbon­yl)-4H-chromen-4-one (3) and 2-(pyrrolidine-1-carbon­yl)-4H-chromen-4-one (4), which instead of the carboxamide have a carbonyl pyrrolidine linked to the chromone (see Scheme). Compounds (2), (5) and (6), N-methyl-4-oxo-N-phenyl-4H-chromene-2-carboxamide, N-phenyl-4-oxo-4H-3-chromone carboxamide and N-phenyl-4-oxo-4H-2-chromone carboxamide, have previously been characterized by X-ray diffraction (Gomes et al. 2013[Gomes, L. R., Low, J. N., Cagide, F., Gaspar, A., Reis, J. & Borges, F. (2013). Acta Cryst. B69, 294-309.], Cagide et al., 2015[Cagide, F., Silva, T., Reis, J., Gaspar, A., Borges, F., Gomes, L. R. & Low, J. N. (2015). Chem. Commun. 51, 2832-2835.] and Reis et al., 2014[Reis, J., Gaspar, A., Borges, F., Gomes, L. R. & Low, J. N. (2014). J. Mol. Struct. 1056-1057, 31-37.], respectively). They will be used in this study for comparative purposes.

[Scheme 1]

2. Structural commentary

2.1. Mol­ecular Conformations

As mentioned above, the compounds discussed in this work are presented in the Scheme. Compounds (2), (5) and (6) have previously been characterized. The ellipsoid plots for the remaining structures, e.g. for (1), (3) and (4), are given in Figs. 1[link]–3[link][link]. The results of the biological tests show that only (5) exhibits significant IMAO-B activity. Its isomer (6) is much less active while the remaining ones are inactive towards MAO-B, suggesting that substitution on position number 3 of the chromone is required and it must be a secondary carboxamide. As will be discussed, the presence of a tertiary amide induces significant conformational changes to the compounds that can explain the lack of activity for those compounds.

[Figure 1]
Figure 1
A view of the asymmetric unit of (1) with the atom-numbering scheme. Displacement ellipsoids are drawn at the 70% probability level.
[Figure 2]
Figure 2
A view of the asymmetric unit of (3) with the atom-numbering scheme. Displacement ellipsoids are drawn at the 70% probability level.
[Figure 3]
Figure 3
A view of the asymmetric unit of (4) with the atom-numbering scheme. Displacement ellipsoids are drawn at the 70% probability level.

Compound (1) is a phenyl chromone carboxamide similar to (5) where the amidic hydrogen atom has been replaced by a methyl substituent. Since the nitro­gen atom of the amide tends to be planar due to the partial sp2 hybridization of the C—N bond and, owing to the high rotational barrier around that bond, amides often exhibit –anti/–syn conformations with respect to the C–N rotamer. The inactive chromone carboxamides (1) and (2) present –syn conformations whereas chomone (5) (active) and (6) (inactive) are in the –anti form. In (5) and (6) the aromatic rings are roughly co-planar [dihedral angles between the mean planes of the aromatic rings are 10.77 (4) (Cagide et al., 2015[Cagide, F., Silva, T., Reis, J., Gaspar, A., Borges, F., Gomes, L. R. & Low, J. N. (2015). Chem. Commun. 51, 2832-2835.]) and 6.57 (7)° (Reis et al., 2013[Reis, J., Gaspar, A., Borges, F., Gomes, L. R. & Low, J. N. (2013). Acta Cryst. C69, 1527-1533.]), respectively], while in compounds (1) and (2) the aromatic rings are twisted with respect to each other [dihedral angles between the mean planes of the chromone and the exocyclic phenyl rings are 58.48 (8) and 73.86 (5)° (Gomes et al., 2013[Gomes, L. R., Low, J. N., Cagide, F., Gaspar, A., Reis, J. & Borges, F. (2013). Acta Cryst. B69, 294-309.]), respectively]. The twisting is probably driven by the minimization of steric hindrance that would arise from the prox­imity of the rings.

Mol­ecules (3) and (4) present a chromone residue and an exocycle pyrrolidine ring separated by a carbonyl spacer. The pyrrolidine ring in (3) assumes a mostly envelope shape as it is puckered at C313, with θ(2) = 0.349 (5) Å and φ(2) = 78.8 (7)°. In (4) the pyrrolidine conformation is between an envelope and a half-chair, the ring being twisted at C213—C214, with θ(2) = 0.380 (3) Å and φ(2) = 91.0 (3)°. The inactive pyrrolidines (3) and (4) also display a high degree of torsion; the dihedral angles between the chromone and the best plane formed by the pyrrolidine atoms are 48.9 (2) and 23.97 (12)° respectively. A close analysis of the –(C=O)—N bond lengths for (3) [1.337 (4) Å] and (4) [1.340 (3) Å] shows that these values are comparable with those presented for the corresponding bonds in the carboxamides (1) [1.361 (2) Å] and (2) [1.3528 (14) Å], indicating partial sp2 hybridization of the nitro­gen atom in (3) and (4). Furthermore, a search made in the Cambridge Structural Database (Groom & Allen, 2014[Groom, C. R. & Allen, F. H. (2014). Angew. Chem. Int. Ed. 53, 662-671.]) for structures containing the pyrrolidinecarbonyl unit (see Database survey section below) shows that the C—N distances range between 1.294 and 1.361 Å [the mean value is 1.335 (2) Å], suggesting that in carbonyl pyrrolidines the C—N bond displays partial hybrid­ization (Laursen et al., 2013[Laursen, J. S., Engel-Andreasen, J., Fristrup, P., Harris, P. & Olsen, C. A. (2013). J. Am. Chem. Soc. 135, 2835-2844.]).

2.2. Intra­molecular C—H⋯O bonding

There is no intra­molecular hydrogen bonding in compounds (1) and (2). This contrasts with what occurs in (5) and (6) where, due to the presence of the imidic nitro­gen atom, the mol­ecules display N—H⋯O intra­molecular S(6) rings and, due to the –anti configuration, they present weak Carom—H⋯O hydrogen bonds (the carbonyl group of the amide acting as acceptor for the ortho-carbon atom of the benzyl ring), resulting in second S(6) rings (Cagide et al., 2015[Cagide, F., Silva, T., Reis, J., Gaspar, A., Borges, F., Gomes, L. R. & Low, J. N. (2015). Chem. Commun. 51, 2832-2835.]; Reis et al., 2014[Reis, J., Gaspar, A., Borges, F., Gomes, L. R. & Low, J. N. (2014). J. Mol. Struct. 1056-1057, 31-37.]). In (3) there is a short intra­molecular contact C312—H312⋯O4 in which the pyrollidine carbon atom acts as a donor to the carbonyl oxygen atom, O4, of the chromone, forming an S(7) ring. The search of the CSD (Groom & Allen, 2014[Groom, C. R. & Allen, F. H. (2014). Angew. Chem. Int. Ed. 53, 662-671.]) described below found five mol­ecules containing a pyrrolidine carbonyl moiety that exhibit similar intra­molecular hydrogen bonding. In conclusion, apart from precluding the formation of an intra­molecular N—H⋯A bond, substitution of the amidic hydrogen atom by a methyl group in the carboxamide or the insertion of a carb­oxy­pyrrolidine unit in the chromone causes a large change in the conformational geometry of the mol­ecules that prevents a link to the active site of the MAO-B enzyme.

3. Supra­molecular features

Details of the hydrogen bonding are given in Tables 1[link], 2[link] and 3[link].

Table 1
Hydrogen-bond geometry (Å, °) for (1)[link]

D—H⋯A D—H H⋯A D⋯A D—H⋯A
C2—H2⋯O4i 0.95 2.47 3.253 (3) 140
C5—H5⋯O1ii 0.95 2.49 3.432 (3) 172
C314—H314⋯O3iii 0.95 2.33 3.255 (3) 164
Symmetry codes: (i) x+1, y, z; (ii) x-1, y, z; (iii) x-1, y+1, z.

Table 2
Hydrogen-bond geometry (Å, °) for (3)[link]

Cg is the centroid of the benzene ring C4A/C5–C8/C8A
D—H⋯A D—H H⋯A D⋯A D—H⋯A
C312—H31A⋯O4 0.99 2.29 3.082 (5) 136
C2—H2⋯O4i 0.95 2.47 3.338 (4) 152
C6—H6⋯O4ii 0.95 2.48 3.389 (4) 161
C8—H8⋯O4iii 0.95 2.57 3.514 (4) 170
C314—H31E⋯O3iv 0.99 2.42 3.128 (5) 128
C313—H31D⋯Cgv 0.99 2.59 3.570 (6) 170
Symmetry codes: (i) [x+{\script{1\over 2}}, -y+{\script{3\over 2}}, -z+1]; (ii) [-x+1, y-{\script{1\over 2}}, -z+{\script{1\over 2}}]; (iii) [-x+{\script{3\over 2}}, -y+1, z+{\script{1\over 2}}]; (iv) [-x+{\script{3\over 2}}, -y+2, z-{\script{1\over 2}}]; (v) [x-{\script{1\over 2}}, -y+{\script{3\over 2}}, -z+1].

Table 3
Hydrogen-bond geometry (Å, °) for (4)[link]

D—H⋯A D—H H⋯A D⋯A D—H⋯A
C8—H8⋯O2i 0.95 2.55 3.137 (3) 121
C214—H21C⋯O4ii 0.99 2.47 3.340 (3) 146
Symmetry codes: (i) [x+{\script{1\over 2}}, -y+{\script{1\over 2}}, z]; (ii) [-x+1, -y+{\script{1\over 2}}, z-{\script{1\over 2}}].

In compound (1) the C2—H2⋯O4(x + 1, y, z) and C5—H5⋯O1(x + 1, y, z) hydrogen bonds link the mol­ecules into R22(8) rings which link the, mol­ecules into chains running parallel to the a axis, Fig. 4[link]. These chains are then linked by the C314—314⋯O3(x − 1, y + 1, z) hydrogen bond, Fig. 5[link], to form sheets lying parallel to [001], Fig. 6[link]. A centrosymmetric sheet inter­penetrates the first sheet, and these two sheets are linked by π–π stacking between the chromone rings [centroid–centroid distance = 3.557 (2) Å].

[Figure 4]
Figure 4
Compound (1): the chain of R22(8) rings running parallel to the a axis. Hydrogen atoms not involved in the hydrogen bonding are omitted.
[Figure 5]
Figure 5
Compound (1): the chain formed by the C314—314⋯O3 hydrogen bond. Hydrogen atoms not involved in the hydrogen bonding are omitted.
[Figure 6]
Figure 6
Compound (1): view of the sheets which lie parallel to [001] formed by the combination of the chains shown in Figs. 4[link] and 5[link]. Hydrogen atoms not involved in the hydrogen bonding are omitted.

In compound (3) the mol­ecules are linked by C—H⋯O inter­actions and by C—H⋯π inter­actions. The C8—H8⋯O4(−x + [{3\over 2}], −y + 1, z + [{1\over 2}]) and C314—H31E⋯O3(−x + [{3\over 2}], −y + 2, z − [{1\over 2}]) contacts both form C(6) chains running parallel to the c axis which are propagated by the twofold screw axes at ([{3\over 4}], [{1\over 2}], z) and ([{3\over 4}], 1, z), respectively, Figs. 7[link] and 8[link]. These combine to form a corrugated sheet in the bc plane, Fig. 9[link]. The C2—H2⋯O4(x + [{1\over 2}], −y + [{3\over 2}], −z + 1) inter­action links the mol­ecules into C(5) chains running along the a axis propagated by the twofold screw axis at (x, [{3\over 4}], [{1\over 2}]), Fig. 10[link]. The C6—H6⋯O4(−x + 1, y − [{1\over 2}], −z + [{1\over 2}]) inter­action links the mol­ecules into C(6) chains running along the b axis which are propagated by the twofold screw axis at ([{1\over 2}], y, [{1\over 4}]), Fig. 11[link]. There is also a C—H⋯π inter­action C313—H31D⋯Cg(x − 2, y + [{1\over 2}], −z + [{1\over 2}]). These inter­actions combine to form a complex three-dimensional network.

[Figure 7]
Figure 7
Compound (3): mol­ecular C(6) chain running parallel to the c axis. Mol­ecules i and ii are at (−x + [{3\over 2}], −y + 1, z + [{1\over 2}]) and (−x + [{3\over 2}], −y + 1, z − [{1\over 2}]), respectively. Hydrogen atoms not involved in the hydrogen bonding are omitted.
[Figure 8]
Figure 8
Compound (3): mol­ecular C(6) chain running parallel to the c axis. Mol­ecules i and ii are at (−x + [{3\over 2}], −y + 2, z − [{1\over 2}]) and (−x + [{3\over 2}], −y + 2, z + [{1\over 2}]), respectively. Hydrogen atoms not involved in the hydrogen bonding are omitted.
[Figure 9]
Figure 9
Compound (3): corrugated sheet in the bc plane formed by the inter­actions of the two C(6) chains shown in Figs. 7[link] and 8[link]. Hydrogen atoms not involved in the hydrogen bonding are omitted.
[Figure 10]
Figure 10
Compound (3): mol­ecular C(5) chain running parallel to the a axis. Mol­ecules i, ii and iii are at (x + [{1\over 2}], −y + [{3\over 2}], −z + 1), (x − [{1\over 2}], −y + [{3\over 2}], −z + 1) and (x − 1, y, z), respectively. Hydrogen atoms not involved in the hydrogen bonding are omitted.
[Figure 11]
Figure 11
Compound (3): mol­ecular C(6) chain running parallel to the b axis. Mol­ecules i and ii are at (−x + 1, y − [{1\over 2}], −z + [{1\over 2}]) and (−x + 1, y + [{1\over 2}], −z + [{1\over 2}]), respectively. Hydrogen atoms not involved in the hydrogen bonding are omitted.

In compound (4) there is a short contact between C214—H21C and O4(−x + 1, −y + [{1\over 2}], z − [{1\over 2}]). This forms a C(9) chain which runs along the c axis, propagated by the twofold screw axis at ([{1\over 2}], [{1\over 4}], z), Fig. 12[link]. There is also a short contact between C8—H8 and O2(x + [{1\over 2}], −y − [{1\over 2}], z) but in this case the angle at H8 is 121° and so this inter­action will be relatively weak. It forms a C(7) chain parallel to the a axis propagated by the glideplane at [{1\over 4}] along the b axis, Fig. 13[link]. There are no C—H⋯π or π–π inter­actions.

[Figure 12]
Figure 12
Compound (4): mol­ecular C(9) chain running parallel to the c axis. Mol­ecules i, ii and iii are at (−x + 1, −y + [{1\over 2}], z − [{1\over 2}]), (−x + 1, −y + [{1\over 2}], z + [{1\over 2}]) and (x, y, z + 1), respectively. Hydrogen atoms not involved in the hydrogen bonding are omitted.
[Figure 13]
Figure 13
Compound (4): mol­ecular C(7) chain running parallel to the a axis. Mol­ecules i and ii are at (x + [{1\over 2}], −y − [{1\over 2}], z) and (x − [{1\over 2}], −y − [{1\over 2}], z), respectively. Hydrogen atoms not involved in the hydrogen bonding are omitted.

4. Database survey

A search of the Cambridge Structural Database (Groom & Allen, 2014[Groom, C. R. & Allen, F. H. (2014). Angew. Chem. Int. Ed. 53, 662-671.]) gave 45 hits for the pyrrolidinecarbonyl group for structures with R ≤ 0.10 (see supplementary data for the search fragment). The mean value for the C—O bond length was 1.235 (2) Å with a range of 1.209–1.282 Å. The values for (3) and (4) are 1.239 (4) and 1.230 (2) Å, respectively. The mean C—N bond length is 1.335 (2) Å with a range of 1.294–1.361Å. The values for (3) and (4) are 1.337 (4) and 1.340 (3) Å, respectively. The values for these compounds are close to the mean values in each case.

The torsion angles around the C(carbon­yl) and N(pyrrolidine) bond involving the carbonyl O atom lie in ranges between −9.15 and 8.023° with a mean value of close to zero and between −161.33 and 166.71° with a mean value close to 180° for both the C atoms attached to the N atom within the pyrolidine group. The respective torsion angles for (3) [−0.5 (5) and 171.9 (3)°] and those for (4) [1.1 (3) and −175.3 (2)°] are well within the ranges specified above.

Intra­molecular C—H⋯O short contacts similar to that in (3) are found in five compounds in the CSD: LISLAB, 1-(1-pyrrolidinylcarbon­yl)cyclo­propyl sulfamate (Morin et al., 2007[Morin, M. S. T., Toumieux, S., Compain, P., Peyrat, S. & Kalinowska-Tluscik, J. (2007). Tetrahedron Lett. 48, 8531-8535.]), PEQHAU, 2-[3′-(4′′-chloro­phen­yl)-4′,6′-di­meth­oxy­indol-7′-yl]glyoxyl-1-pyrrolidine (Black et al., 1997[Black, D. St C., Craig, D. C. & McConnell, D. B. (1997). Tetrahedron Lett. 38, 4287-4290.]), QIBBEJ, [2-hy­droxy-5-(2-hy­droxy­benzo­yl)phen­yl](pyrrolidin-1-yl)methanone (Holtz et al., 2007[Holtz, E., Albrecht, U. & Langer, P. (2007). Tetrahedron, 63, 3293-3301.]), SINHAZ, 2-meth­oxy-1-(1-pyrrolidinylcarbon­yl)naphthalene (Sakamoto et al., 2007[Sakamoto, M., Unosawa, A., Kobaru, S., Fujita, K., Mino, T. & Fujita, T. (2007). Chem. Commun. pp. 3586-3588.]) and TAJDIR, (4S,5S)-4,5-bis­(pyrrolidinylcarbon­yl)-2,2-dimethyl-1,3-dioxolane (Garcia et al., 1991[Garcia, J. G., Fronczek, F. R. & McLaughlin, M. L. (1991). Acta Cryst. C47, 206-209.]), Fig. 10[link]. In LISLAB and TAJDIR, S(6) rings are formed. In QIBBEJ and SINHAZ, an S(7) ring similar to that in (2) is formed. In PEQHAU, an S(8) ring is formed, Fig. 14[link].

[Figure 14]
Figure 14
View of compounds in the CSD with C—H⋯O short intra­molecular contacts involving an o-pyrolidine hydrogen atom.

5. Synthesis and crystallization

N-methyl-4-oxo-N-phenyl-4H-chromene-3-carboxamide, (1) was synthesized in a low yield (10%) by a one-pot reaction using 4-oxo-4H-chromene-3-carb­oxy­lic acid as starting mat­erial. The activation of the carb­oxy­lic acid was obtained by the coupling reagent bromo­tripyrrolidino­phospho­nium hexa­fluoro­phosphate (PyBrOP) and the amide obtained by reacting the ester derivative with N-methyl­aniline. The crude product was purified by flash chromatography (ethyl acetate and ethyl acetate/ CH2Cl2 in an 4:1 ratio). Crystals suitable for X-ray diffraction were obtained from ethyl acetate.

3-(Pyrrolidine-1-carbon­yl)-4H-chromen-4-one, (3) and 2-(pyrrolidine-1-carbon­yl)-4H-chromen-4-one, (4) were synthesized in moderate yields, 57% and 45%, by a one-pot reaction using 4-oxo-4H-chromene-3-carb­oxy­lic and 4-oxo-4H-chromene-2-carb­oxy­lic acids, respectively, as starting materials. The synthetic strategy encompasses the activation of the chromone carb­oxy­lic acids by reaction with phospho­rus(V) oxychloride with formation in situ of an acid chloride inter­mediate. The acid chlorides react with pyrrolidine giving the desired amides. Crystals suitable for X-ray diffraction for both compounds were obtained from a solution of CH2Cl2/n-hexane solvent 1:1, m.p. for (3): 421–426K; m.p. for (4): 382–386K.

6. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 4[link]. H atoms were treated as riding atoms with C—H(aromatic) = 0.95 Å and C—H(CH2) = 0.99 Å with Uiso = 1.2Ueq(C), and C—H(meth­yl) = 0.98Å with Uiso = 1.5Ueq(C). The methyl hydrogen atoms were generated in idealized positions and checked on a final difference map.

Table 4
Experimental details

  (1) (3) (4)
Crystal data
Chemical formula C17H13NO3 C14H13NO3 C14H13NO3
Mr 279.28 243.25 243.25
Crystal system, space group Monoclinic, P21/c Orthorhombic, P212121 Orthorhombic, Aba2
Temperature (K) 100 100 100
a, b, c (Å) 6.716 (4), 6.809 (4), 29.425 (17) 7.430 (3), 11.963 (6), 12.648 (6) 15.337 (6), 21.940 (8), 6.808 (3)
α, β, γ (°) 90, 94.784 (7), 90 90, 90, 90 90, 90, 90
V (Å3) 1340.9 (14) 1124.2 (9) 2290.8 (16)
Z 4 4 8
Radiation type Mo Kα Mo Kα Mo Kα
μ (mm−1) 0.10 0.10 0.10
Crystal size (mm) 0.25 × 0.07 × 0.06 0.22 × 0.07 × 0.03 0.50 × 0.04 × 0.02
 
Data collection
Diffractometer Rigaku Saturn724+ Rigaku Saturn724+ Rigaku Saturn724+
Absorption correction Multi-scan (CrystalClear-SM Expert; Rigaku, 2012[Rigaku (2012). CrystalClear SM Expert. Rigaku Corporation, Tokyo, Japan.]) Multi-scan (CrystalClear-SM Expert; Rigaku, 2012[Rigaku (2012). CrystalClear SM Expert. Rigaku Corporation, Tokyo, Japan.]) Multi-scan (CrystalClear-SM Expert; Rigaku, 2012[Rigaku (2012). CrystalClear SM Expert. Rigaku Corporation, Tokyo, Japan.])
Tmin, Tmax 0.572, 1.000 0.978, 0.997 0.952, 0.998
No. of measured, independent and observed [I > 2σ(I)] reflections 6206, 3032, 2304 7547, 3294, 3066 9598, 3374, 3079
Rint 0.043 0.031 0.034
(sin θ/λ)max (Å−1) 0.648 0.731 0.731
 
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.056, 0.133, 1.07 0.069, 0.152, 1.07 0.048, 0.102, 1.11
No. of reflections 3032 3294 3374
No. of parameters 190 163 163
No. of restraints 0 0 1
H-atom treatment H-atom parameters constrained H-atom parameters constrained H-atom parameters constrained
Δρmax, Δρmin (e Å−3) 0.30, −0.25 0.51, −0.44 0.32, −0.21
Computer programs: CrystalClear-SM Expert (Rigaku, 2012[Rigaku (2012). CrystalClear SM Expert. Rigaku Corporation, Tokyo, Japan.]), SHELXS (Sheldrick, 2015[Sheldrick, G. M. (2015). Acta Cryst. C71, 3-8.]), SHELXL2014/17 (Sheldrick, 2015[Sheldrick, G. M. (2015). Acta Cryst. C71, 3-8.]) PLATON (Spek, 2009[Spek, A. L. (2009). Acta Cryst. D65, 148-155.]) Flipper 25 (Oszlányi & Sütő, 2004[Oszlányi, G. & Sütő, A. (2004). Acta Cryst. A60, 134-141.]) OLEX2 (Dolomanov et al., 2009[Dolomanov, O. V., Bourhis, L. J., Gildea, R. J., Howard, J. A. K. & Puschmann, H. (2009). J. Appl. Cryst. 42, 339-341.], OSCAIL (McArdle et al., 2004[McArdle, P., Gilligan, K., Cunningham, D., Dark, R. & Mahon, M. (2004). CrystEngComm, 6, 303-309.]), ShelXle (Hübschle et al., 2011[Hübschle, C. B., Sheldrick, G. M. & Dittrich, B. (2011). J. Appl. Cryst. 44, 1281-1284.]) and Mercury (Macrae et al., 2006[Macrae, C. F., Edgington, P. R., McCabe, P., Pidcock, E., Shields, G. P., Taylor, R., Towler, M. & van de Streek, J. (2006). J. Appl. Cryst. 39, 453-457.]).

Supporting information

CCDC references: 1427459; 1427458; 1025355

Crystal structure: contains datablocks general, 1, 3, 4. DOI: https://doi.org/10.1107/S2056989015017958/lh5791sup1.cif

Structure factors: contains datablock 1. DOI: https://doi.org/10.1107/S2056989015017958/lh57911sup2.hkl

Structure factors: contains datablock 3. DOI: https://doi.org/10.1107/S2056989015017958/lh57913sup3.hkl

Structure factors: contains datablock 4. DOI: https://doi.org/10.1107/S2056989015017958/lh57914sup4.hkl

Supporting information file. DOI: https://doi.org/10.1107/S2056989015017958/lh57911sup5.cml

Supporting information file. DOI: https://doi.org/10.1107/S2056989015017958/lh57913sup6.cml

Supporting information file. DOI: https://doi.org/10.1107/S2056989015017958/lh57914sup7.cml

checkCIF report


Computing details top

For all compounds, data collection: CrystalClear-SM Expert (Rigaku, 2012); cell refinement: CrystalClear-SM Expert (Rigaku, 2012); data reduction: CrystalClear-SM Expert (Rigaku, 2012). Program(s) used to solve structure: SHELXS (Sheldrick, 2015), PLATON (Spek, 2009), Flipper 25 (Oszlányi & Sütő, 2004) and Olex2 (Dolomanov et al., 2009 for (1); SHELXS (Sheldrick, 2015), PLATON (Spek, 2009), Flipper 25 (Oszlányi & Sütő, 2004) and Olex2 (Dolomanov et al., 2009). for (3); SHELXS (Sheldrick, 2015), PLATON (Spek, 2009), Flipper 25 (Oszlányi & Sütő, 2004) and Olex2 (Dolomanov et al., 2009) for (4). For all compounds, program(s) used to refine structure: OSCAIL (McArdle et al., 2004), ShelXle (Hübschle et al., 2011) and SHELXL2014/17 (Sheldrick, 2015); molecular graphics: Mercury (Macrae et al., 2006); software used to prepare material for publication: OSCAIL (McArdle et al., 2004), SHELXL2014/17 (Sheldrick, 2015) and PLATON (Spek, 2009).

(1) N-Methyl-4-oxo-N-phenyl-4H-chromene-3-carboxamide top
Crystal data top
C17H13NO3Z = 4
Mr = 279.28F(000) = 584
Monoclinic, P21/cDx = 1.383 Mg m−3
a = 6.716 (4) ÅMo Kα radiation, λ = 0.71075 Å
b = 6.809 (4) ŵ = 0.10 mm−1
c = 29.425 (17) ÅT = 100 K
β = 94.784 (7)°Rod, colourless
V = 1340.9 (14) Å30.25 × 0.07 × 0.06 mm
Data collection top
Rigaku Saturn724+
diffractometer		3032 independent reflections
Radiation source: Rotating Anode2304 reflections with I > 2σ(I)
Confocal monochromatorRint = 0.043
Detector resolution: 28.5714 pixels mm-1θmax = 27.4°, θmin = 3.0°
profile data from ω–scansh = −8→8
Absorption correction: multi-scan
(CrystalClear-SM Expert; Rigaku, 2012)		k = −8→8
Tmin = 0.572, Tmax = 1.000l = −17→38
6206 measured reflections
Refinement top
Refinement on F20 restraints
Least-squares matrix: fullHydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.056H-atom parameters constrained
wR(F2) = 0.133 w = 1/[σ2(Fo2) + (0.0336P)2 + 1.136P]
where P = (Fo2 + 2Fc2)/3
S = 1.07(Δ/σ)max < 0.001
3032 reflectionsΔρmax = 0.30 e Å−3
190 parametersΔρmin = −0.25 e Å−3
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
O10.6806 (2)0.7176 (2)0.54188 (5)0.0226 (3)
O30.6513 (2)0.4530 (2)0.66760 (5)0.0351 (4)
O40.1517 (2)0.5956 (2)0.59524 (5)0.0219 (3)
N30.4090 (3)0.6598 (2)0.68645 (5)0.0204 (4)
C20.6722 (3)0.6736 (3)0.58634 (7)0.0206 (4)
H20.79520.66040.60450.025*
C30.5026 (3)0.6467 (3)0.60699 (6)0.0181 (4)
C40.3091 (3)0.6483 (3)0.58017 (6)0.0176 (4)
C4A0.3200 (3)0.7089 (3)0.53230 (6)0.0175 (4)
C50.1473 (3)0.7317 (3)0.50257 (7)0.0225 (4)
H50.01960.71390.51360.027*
C60.1615 (3)0.7800 (3)0.45738 (7)0.0262 (5)
H60.04370.79700.43760.031*
C70.3497 (3)0.8040 (3)0.44074 (7)0.0250 (5)
H70.35860.83420.40950.030*
C80.5213 (3)0.7842 (3)0.46923 (7)0.0228 (4)
H80.64880.80180.45810.027*
C8A0.5041 (3)0.7376 (3)0.51492 (6)0.0184 (4)
C310.5272 (3)0.5798 (3)0.65592 (7)0.0218 (4)
C320.4238 (4)0.5723 (3)0.73235 (7)0.0329 (6)
H32A0.33280.64090.75130.049*
H32B0.38720.43310.73020.049*
H32C0.56120.58480.74610.049*
C3110.2721 (3)0.8175 (3)0.67737 (6)0.0180 (4)
C3120.0764 (3)0.7959 (4)0.68895 (7)0.0296 (5)
H3120.03380.67520.70110.036*
C313−0.0547 (4)0.9506 (5)0.68268 (8)0.0428 (7)
H313−0.18790.93610.69080.051*
C3140.0046 (4)1.1271 (4)0.66470 (8)0.0450 (8)
H314−0.08731.23300.66050.054*
C3150.1985 (4)1.1481 (3)0.65283 (8)0.0352 (6)
H3150.23941.26790.63990.042*
C3160.3337 (3)0.9941 (3)0.65974 (6)0.0225 (4)
H3160.46791.00980.65240.027*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
O10.0171 (7)0.0268 (8)0.0242 (7)0.0015 (6)0.0046 (6)−0.0019 (6)
O30.0367 (10)0.0375 (9)0.0303 (8)0.0219 (8)−0.0014 (7)0.0022 (7)
O40.0176 (7)0.0269 (8)0.0215 (7)−0.0015 (6)0.0035 (5)0.0009 (6)
N30.0232 (9)0.0203 (8)0.0178 (8)0.0059 (7)0.0024 (7)0.0032 (6)
C20.0162 (10)0.0218 (10)0.0236 (10)0.0045 (8)−0.0001 (8)−0.0030 (8)
C30.0151 (10)0.0187 (9)0.0206 (9)0.0021 (8)0.0018 (7)−0.0025 (7)
C40.0164 (10)0.0161 (9)0.0203 (9)0.0013 (8)0.0024 (7)−0.0019 (7)
C4A0.0180 (10)0.0153 (9)0.0195 (9)0.0008 (8)0.0032 (7)−0.0026 (7)
C50.0181 (10)0.0257 (11)0.0238 (10)−0.0004 (9)0.0025 (8)−0.0009 (8)
C60.0254 (11)0.0299 (12)0.0227 (10)0.0018 (10)−0.0019 (8)0.0010 (8)
C70.0343 (12)0.0213 (10)0.0202 (9)−0.0002 (9)0.0063 (9)0.0007 (8)
C80.0254 (11)0.0181 (10)0.0263 (10)0.0004 (9)0.0101 (8)−0.0027 (8)
C8A0.0178 (10)0.0148 (9)0.0227 (9)0.0012 (8)0.0024 (8)−0.0029 (7)
C310.0190 (10)0.0226 (10)0.0235 (10)0.0049 (9)−0.0005 (8)0.0002 (8)
C320.0523 (16)0.0281 (12)0.0183 (10)0.0063 (11)0.0021 (10)0.0045 (8)
C3110.0160 (10)0.0215 (10)0.0162 (8)0.0055 (8)−0.0006 (7)−0.0028 (7)
C3120.0219 (11)0.0415 (13)0.0257 (10)0.0011 (10)0.0035 (9)−0.0075 (9)
C3130.0223 (12)0.071 (2)0.0347 (13)0.0161 (13)−0.0016 (10)−0.0213 (13)
C3140.0448 (16)0.0515 (17)0.0355 (13)0.0353 (14)−0.0166 (12)−0.0195 (12)
C3150.0542 (16)0.0229 (11)0.0257 (11)0.0127 (11)−0.0121 (11)−0.0039 (9)
C3160.0254 (11)0.0232 (10)0.0181 (9)0.0021 (9)−0.0023 (8)−0.0017 (8)
Geometric parameters (Å, º) top
O1—C21.348 (2)C7—C81.374 (3)
O1—C8A1.377 (2)C7—H70.9500
O3—C311.229 (2)C8—C8A1.395 (3)
O4—C41.233 (2)C8—H80.9500
N3—C311.361 (3)C32—H32A0.9800
N3—C3111.425 (3)C32—H32B0.9800
N3—C321.472 (3)C32—H32C0.9800
C2—C31.347 (3)C311—C3161.386 (3)
C2—H20.9500C311—C3121.393 (3)
C3—C41.464 (3)C312—C3131.375 (3)
C3—C311.506 (3)C312—H3120.9500
C4—C4A1.476 (3)C313—C3141.385 (4)
C4A—C8A1.391 (3)C313—H3130.9500
C4A—C51.402 (3)C314—C3151.384 (4)
C5—C61.381 (3)C314—H3140.9500
C5—H50.9500C315—C3161.391 (3)
C6—C71.403 (3)C315—H3150.9500
C6—H60.9500C316—H3160.9500
C2—O1—C8A118.54 (16)O1—C8A—C8116.18 (18)
C31—N3—C311125.50 (16)C4A—C8A—C8122.26 (19)
C31—N3—C32116.47 (17)O3—C31—N3121.05 (18)
C311—N3—C32118.03 (17)O3—C31—C3119.82 (18)
C3—C2—O1124.97 (19)N3—C31—C3119.13 (17)
C3—C2—H2117.5N3—C32—H32A109.5
O1—C2—H2117.5N3—C32—H32B109.5
C2—C3—C4120.15 (18)H32A—C32—H32B109.5
C2—C3—C31116.29 (18)N3—C32—H32C109.5
C4—C3—C31122.62 (17)H32A—C32—H32C109.5
O4—C4—C3123.61 (18)H32B—C32—H32C109.5
O4—C4—C4A122.49 (18)C316—C311—C312120.02 (19)
C3—C4—C4A113.82 (17)C316—C311—N3121.05 (18)
C8A—C4A—C5118.01 (18)C312—C311—N3118.83 (19)
C8A—C4A—C4120.47 (17)C313—C312—C311119.6 (2)
C5—C4A—C4121.47 (18)C313—C312—H312120.2
C6—C5—C4A120.51 (19)C311—C312—H312120.2
C6—C5—H5119.7C312—C313—C314121.0 (2)
C4A—C5—H5119.7C312—C313—H313119.5
C5—C6—C7120.01 (19)C314—C313—H313119.5
C5—C6—H6120.0C315—C314—C313119.5 (2)
C7—C6—H6120.0C315—C314—H314120.2
C8—C7—C6120.68 (19)C313—C314—H314120.2
C8—C7—H7119.7C314—C315—C316120.1 (2)
C6—C7—H7119.7C314—C315—H315119.9
C7—C8—C8A118.51 (19)C316—C315—H315119.9
C7—C8—H8120.7C311—C316—C315119.8 (2)
C8A—C8—H8120.7C311—C316—H316120.1
O1—C8A—C4A121.54 (17)C315—C316—H316120.1
C8A—O1—C2—C30.1 (3)C7—C8—C8A—O1179.39 (17)
O1—C2—C3—C45.2 (3)C7—C8—C8A—C4A0.7 (3)
O1—C2—C3—C31174.45 (18)C311—N3—C31—O3174.8 (2)
C2—C3—C4—O4168.55 (19)C32—N3—C31—O3−6.1 (3)
C31—C3—C4—O40.0 (3)C311—N3—C31—C3−6.0 (3)
C2—C3—C4—C4A−8.3 (3)C32—N3—C31—C3173.13 (19)
C31—C3—C4—C4A−176.85 (17)C2—C3—C31—O3−42.0 (3)
O4—C4—C4A—C8A−169.94 (18)C4—C3—C31—O3126.9 (2)
C3—C4—C4A—C8A7.0 (3)C2—C3—C31—N3138.8 (2)
O4—C4—C4A—C57.5 (3)C4—C3—C31—N3−52.3 (3)
C3—C4—C4A—C5−175.54 (18)C31—N3—C311—C316−54.2 (3)
C8A—C4A—C5—C60.5 (3)C32—N3—C311—C316126.7 (2)
C4—C4A—C5—C6−177.09 (19)C31—N3—C311—C312129.5 (2)
C4A—C5—C6—C70.9 (3)C32—N3—C311—C312−49.6 (3)
C5—C6—C7—C8−1.4 (3)C316—C311—C312—C3130.1 (3)
C6—C7—C8—C8A0.7 (3)N3—C311—C312—C313176.53 (19)
C2—O1—C8A—C4A−1.6 (3)C311—C312—C313—C3140.5 (3)
C2—O1—C8A—C8179.71 (17)C312—C313—C314—C3150.1 (4)
C5—C4A—C8A—O1−179.89 (17)C313—C314—C315—C316−1.2 (3)
C4—C4A—C8A—O1−2.3 (3)C312—C311—C316—C315−1.3 (3)
C5—C4A—C8A—C8−1.2 (3)N3—C311—C316—C315−177.58 (18)
C4—C4A—C8A—C8176.34 (18)C314—C315—C316—C3111.8 (3)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
C2—H2···O4i0.952.473.253 (3)140
C5—H5···O1ii0.952.493.432 (3)172
C314—H314···O3iii0.952.333.255 (3)164
Symmetry codes: (i) x+1, y, z; (ii) x−1, y, z; (iii) x−1, y+1, z.
(3) 3-(Pyrrolidine-1-carbonyl)-4H-chromen-4-one top
Crystal data top
C14H13NO3Dx = 1.437 Mg m−3
Mr = 243.25Mo Kα radiation, λ = 0.71075 Å
Orthorhombic, P212121Cell parameters from 4253 reflections
a = 7.430 (3) Åθ = 2.3–31.2°
b = 11.963 (6) ŵ = 0.10 mm−1
c = 12.648 (6) ÅT = 100 K
V = 1124.2 (9) Å3Lath, colourless
Z = 40.22 × 0.07 × 0.03 mm
F(000) = 512
Data collection top
Rigaku Saturn724+
diffractometer		3294 independent reflections
Radiation source: Rotating Anode3066 reflections with I > 2σ(I)
Confocal monochromatorRint = 0.031
Detector resolution: 28.5714 pixels mm-1θmax = 31.3°, θmin = 2.3°
profile data from ω–scansh = −8→10
Absorption correction: multi-scan
(CrystalClear-SM Expert; Rigaku, 2012)		k = −17→15
Tmin = 0.978, Tmax = 0.997l = −18→18
7547 measured reflections
Refinement top
Refinement on F2Hydrogen site location: inferred from neighbouring sites
Least-squares matrix: fullH-atom parameters constrained
R[F2 > 2σ(F2)] = 0.069 w = 1/[σ2(Fo2) + (0.0459P)2 + 1.1472P]
where P = (Fo2 + 2Fc2)/3
wR(F2) = 0.152(Δ/σ)max < 0.001
S = 1.07Δρmax = 0.51 e Å−3
3294 reflectionsΔρmin = −0.44 e Å−3
163 parametersAbsolute structure: Flack x determined using 946 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons et al., 2013)
0 restraintsAbsolute structure parameter: −0.1 (6)
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
O10.8069 (3)0.5658 (2)0.58566 (17)0.0247 (5)
O30.6707 (4)0.8949 (2)0.5280 (2)0.0362 (6)
O40.5779 (3)0.66383 (19)0.30612 (18)0.0255 (5)
N3110.7972 (4)0.8846 (2)0.3665 (2)0.0292 (6)
C20.7960 (5)0.6739 (3)0.5573 (2)0.0254 (7)
H20.83740.72770.60680.030*
C30.7316 (4)0.7126 (3)0.4646 (2)0.0224 (6)
C40.6548 (4)0.6348 (3)0.3885 (2)0.0215 (6)
C4A0.6710 (4)0.5165 (3)0.4186 (2)0.0212 (6)
C50.6124 (4)0.4305 (3)0.3517 (2)0.0236 (6)
H50.55960.44850.28550.028*
C60.6304 (5)0.3197 (3)0.3812 (3)0.0263 (7)
H60.59100.26200.33510.032*
C70.7069 (5)0.2928 (3)0.4790 (3)0.0271 (7)
H70.71850.21660.49920.033*
C80.7659 (5)0.3762 (3)0.5466 (3)0.0259 (6)
H80.81780.35810.61310.031*
C8A0.7474 (4)0.4865 (3)0.5153 (2)0.0223 (6)
C310.7301 (5)0.8378 (3)0.4541 (3)0.0259 (6)
C3120.8921 (6)0.8294 (3)0.2780 (3)0.0318 (8)
H31A0.82450.76340.25230.038*
H31B1.01470.80570.29910.038*
C3130.8989 (7)0.9193 (3)0.1957 (4)0.0430 (10)
H31C0.78810.91920.15220.052*
H31D1.00430.90930.14870.052*
C3140.9147 (8)1.0274 (4)0.2587 (3)0.0477 (12)
H31E0.86851.09160.21750.057*
H31F1.04141.04210.27840.057*
C3150.7994 (5)1.0074 (3)0.3571 (3)0.0360 (8)
H31G0.85421.04240.42030.043*
H31H0.67631.03740.34740.043*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
O10.0315 (12)0.0273 (11)0.0153 (9)−0.0027 (10)−0.0022 (9)−0.0007 (8)
O30.0401 (14)0.0323 (13)0.0362 (14)0.0008 (11)0.0038 (12)−0.0126 (11)
O40.0296 (12)0.0265 (11)0.0202 (10)0.0029 (10)−0.0052 (9)0.0009 (9)
N3110.0379 (16)0.0207 (12)0.0288 (14)−0.0021 (12)−0.0007 (13)−0.0022 (11)
C20.0289 (16)0.0275 (15)0.0196 (14)−0.0026 (13)−0.0011 (13)−0.0041 (12)
C30.0221 (14)0.0245 (14)0.0208 (14)0.0004 (12)0.0003 (12)−0.0033 (11)
C40.0209 (13)0.0247 (14)0.0188 (13)0.0017 (11)0.0018 (11)−0.0011 (11)
C4A0.0195 (13)0.0259 (14)0.0180 (13)−0.0005 (12)0.0013 (11)0.0002 (11)
C50.0246 (14)0.0289 (15)0.0174 (13)−0.0008 (12)0.0003 (12)−0.0013 (11)
C60.0300 (17)0.0246 (15)0.0243 (15)−0.0042 (12)0.0012 (13)−0.0017 (12)
C70.0325 (17)0.0236 (14)0.0252 (15)−0.0005 (13)0.0028 (14)0.0053 (12)
C80.0274 (15)0.0310 (16)0.0193 (14)0.0007 (13)−0.0019 (13)0.0044 (12)
C8A0.0205 (14)0.0292 (15)0.0171 (13)−0.0013 (12)0.0008 (11)−0.0012 (11)
C310.0267 (15)0.0261 (15)0.0250 (14)−0.0003 (13)−0.0040 (13)−0.0043 (12)
C3120.045 (2)0.0271 (16)0.0229 (15)−0.0047 (16)0.0005 (15)0.0001 (13)
C3130.047 (2)0.042 (2)0.040 (2)0.0007 (19)0.010 (2)0.0069 (17)
C3140.076 (3)0.036 (2)0.030 (2)−0.019 (2)−0.009 (2)0.0046 (16)
C3150.042 (2)0.0226 (15)0.044 (2)−0.0042 (15)−0.0086 (17)0.0010 (14)
Geometric parameters (Å, º) top
O1—C21.345 (4)C6—H60.9500
O1—C8A1.374 (4)C7—C81.386 (5)
O3—C311.239 (4)C7—H70.9500
O4—C41.238 (4)C8—C8A1.384 (4)
N311—C311.337 (4)C8—H80.9500
N311—C3151.474 (4)C312—C3131.498 (5)
N311—C3121.480 (5)C312—H31A0.9900
C2—C31.348 (4)C312—H31B0.9900
C2—H20.9500C313—C3141.524 (6)
C3—C41.455 (4)C313—H31C0.9900
C3—C311.504 (4)C313—H31D0.9900
C4—C4A1.471 (4)C314—C3151.529 (6)
C4A—C8A1.396 (4)C314—H31E0.9900
C4A—C51.401 (4)C314—H31F0.9900
C5—C61.383 (5)C315—H31G0.9900
C5—H50.9500C315—H31H0.9900
C6—C71.399 (5)
C2—O1—C8A118.2 (2)O1—C8A—C4A121.4 (3)
C31—N311—C315119.2 (3)C8—C8A—C4A122.4 (3)
C31—N311—C312128.2 (3)O3—C31—N311121.8 (3)
C315—N311—C312112.2 (3)O3—C31—C3119.0 (3)
O1—C2—C3125.7 (3)N311—C31—C3119.2 (3)
O1—C2—H2117.2N311—C312—C313102.8 (3)
C3—C2—H2117.2N311—C312—H31A111.2
C2—C3—C4119.7 (3)C313—C312—H31A111.2
C2—C3—C31114.9 (3)N311—C312—H31B111.2
C4—C3—C31125.1 (3)C313—C312—H31B111.2
O4—C4—C3124.0 (3)H31A—C312—H31B109.1
O4—C4—C4A121.7 (3)C312—C313—C314104.4 (3)
C3—C4—C4A114.3 (3)C312—C313—H31C110.9
C8A—C4A—C5117.8 (3)C314—C313—H31C110.9
C8A—C4A—C4120.5 (3)C312—C313—H31D110.9
C5—C4A—C4121.7 (3)C314—C313—H31D110.9
C6—C5—C4A120.7 (3)H31C—C313—H31D108.9
C6—C5—H5119.7C313—C314—C315104.5 (3)
C4A—C5—H5119.7C313—C314—H31E110.9
C5—C6—C7119.9 (3)C315—C314—H31E110.9
C5—C6—H6120.0C313—C314—H31F110.9
C7—C6—H6120.0C315—C314—H31F110.9
C8—C7—C6120.6 (3)H31E—C314—H31F108.9
C8—C7—H7119.7N311—C315—C314103.2 (3)
C6—C7—H7119.7N311—C315—H31G111.1
C8A—C8—C7118.6 (3)C314—C315—H31G111.1
C8A—C8—H8120.7N311—C315—H31H111.1
C7—C8—H8120.7C314—C315—H31H111.1
O1—C8A—C8116.2 (3)H31G—C315—H31H109.1
C8A—O1—C2—C3−0.2 (5)C5—C4A—C8A—O1−179.5 (3)
O1—C2—C3—C44.3 (5)C4—C4A—C8A—O11.0 (4)
O1—C2—C3—C31178.5 (3)C5—C4A—C8A—C8−0.3 (5)
C2—C3—C4—O4173.1 (3)C4—C4A—C8A—C8−179.8 (3)
C31—C3—C4—O4−0.4 (5)C315—N311—C31—O3−0.5 (5)
C2—C3—C4—C4A−5.3 (4)C312—N311—C31—O3171.9 (3)
C31—C3—C4—C4A−178.8 (3)C315—N311—C31—C3−178.7 (3)
O4—C4—C4A—C8A−175.6 (3)C312—N311—C31—C3−6.3 (5)
C3—C4—C4A—C8A2.8 (4)C2—C3—C31—O3−46.6 (4)
O4—C4—C4A—C54.9 (5)C4—C3—C31—O3127.2 (4)
C3—C4—C4A—C5−176.7 (3)C2—C3—C31—N311131.6 (3)
C8A—C4A—C5—C6−0.1 (5)C4—C3—C31—N311−54.6 (5)
C4—C4A—C5—C6179.4 (3)C31—N311—C312—C313168.7 (4)
C4A—C5—C6—C70.4 (5)C315—N311—C312—C313−18.4 (4)
C5—C6—C7—C8−0.4 (5)N311—C312—C313—C31432.8 (5)
C6—C7—C8—C8A0.0 (5)C312—C313—C314—C315−36.0 (5)
C2—O1—C8A—C8178.2 (3)C31—N311—C315—C314169.9 (3)
C2—O1—C8A—C4A−2.5 (4)C312—N311—C315—C314−3.6 (4)
C7—C8—C8A—O1179.6 (3)C313—C314—C315—N31124.0 (4)
C7—C8—C8A—C4A0.3 (5)
Hydrogen-bond geometry (Å, º) top
Cg is the centroid of the benzene ring C4A/C5–C8/C8A
D—H···AD—HH···AD···AD—H···A
C312—H31A···O40.992.293.082 (5)136
C2—H2···O4i0.952.473.338 (4)152
C6—H6···O4ii0.952.483.389 (4)161
C8—H8···O4iii0.952.573.514 (4)170
C314—H31E···O3iv0.992.423.128 (5)128
C313—H31D···Cgv0.992.593.570 (6)170
Symmetry codes: (i) x+1/2, −y+3/2, −z+1; (ii) −x+1, y−1/2, −z+1/2; (iii) −x+3/2, −y+1, z+1/2; (iv) −x+3/2, −y+2, z−1/2; (v) x−1/2, −y+3/2, −z+1.
(4) 2-(Pyrrolidine-1-carbonyl)-4H-chromen-4-one top
Crystal data top
C14H13NO3Dx = 1.411 Mg m−3
Mr = 243.25Mo Kα radiation, λ = 0.71075 Å
Orthorhombic, Aba2Cell parameters from 3760 reflections
a = 15.337 (6) Åθ = 2.3–31.2°
b = 21.940 (8) ŵ = 0.10 mm−1
c = 6.808 (3) ÅT = 100 K
V = 2290.8 (16) Å3Needle, colourless
Z = 80.50 × 0.04 × 0.02 mm
F(000) = 1024
Data collection top
Rigaku Saturn724+
diffractometer		3374 independent reflections
Radiation source: Rotating Anode3079 reflections with I > 2σ(I)
Confocal monochromatorRint = 0.034
Detector resolution: 28.5714 pixels mm-1θmax = 31.3°, θmin = 2.3°
profile data from ω–scansh = −21→17
Absorption correction: multi-scan
(CrystalClear-SM Expert; Rigaku, 2012)		k = −29→31
Tmin = 0.952, Tmax = 0.998l = −9→8
9598 measured reflections
Refinement top
Refinement on F2Hydrogen site location: inferred from neighbouring sites
Least-squares matrix: fullH-atom parameters constrained
R[F2 > 2σ(F2)] = 0.048 w = 1/[σ2(Fo2) + (0.0386P)2 + 1.0329P]
where P = (Fo2 + 2Fc2)/3
wR(F2) = 0.102(Δ/σ)max < 0.001
S = 1.11Δρmax = 0.32 e Å−3
3374 reflectionsΔρmin = −0.21 e Å−3
163 parametersAbsolute structure: Flack x determined using 1043 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons et al., 2013)
1 restraintAbsolute structure parameter: 1.2 (5)
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
O10.60596 (8)0.22901 (6)0.4803 (2)0.0186 (3)
O20.42149 (9)0.32316 (7)0.4657 (3)0.0254 (4)
O40.42290 (10)0.09521 (7)0.4038 (3)0.0244 (4)
C20.52132 (12)0.24216 (9)0.4484 (3)0.0176 (4)
C30.45851 (13)0.19980 (9)0.4233 (3)0.0193 (4)
H30.39990.21240.40380.023*
C40.47910 (13)0.13519 (9)0.4255 (3)0.0191 (4)
C4A0.57164 (13)0.12141 (9)0.4559 (3)0.0182 (4)
C50.60362 (13)0.06129 (9)0.4609 (4)0.0207 (4)
H50.56470.02810.44230.025*
C60.69058 (14)0.05020 (9)0.4923 (4)0.0227 (5)
H60.71130.00940.49730.027*
C70.74912 (15)0.09874 (9)0.5172 (4)0.0220 (4)
H70.80930.09060.53750.026*
C80.71978 (14)0.15805 (9)0.5122 (3)0.0203 (4)
H80.75920.19110.52860.024*
C8A0.63128 (13)0.16867 (9)0.4826 (3)0.0174 (4)
C210.49892 (13)0.30951 (9)0.4482 (3)0.0186 (4)
N2110.56212 (11)0.35131 (7)0.4300 (3)0.0185 (4)
C2120.53740 (13)0.41656 (8)0.4348 (4)0.0203 (4)
H21G0.50170.42590.55220.024*
H21H0.50430.42800.31560.024*
C2130.62437 (14)0.44949 (9)0.4428 (4)0.0233 (5)
H21E0.64420.45480.58010.028*
H21F0.62070.48990.37890.028*
C2140.68522 (14)0.40700 (10)0.3296 (4)0.0231 (5)
H21C0.67800.41230.18610.028*
H21D0.74690.41460.36480.028*
C2150.65665 (13)0.34367 (9)0.3941 (4)0.0208 (4)
H21A0.66760.31320.28960.025*
H21B0.68740.33090.51520.025*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
O10.0133 (6)0.0152 (6)0.0271 (8)−0.0003 (5)−0.0021 (6)0.0001 (7)
O20.0154 (7)0.0248 (7)0.0360 (10)0.0030 (5)−0.0001 (7)0.0003 (8)
O40.0199 (8)0.0242 (7)0.0289 (10)−0.0073 (6)0.0007 (7)−0.0016 (7)
C20.0166 (9)0.0184 (8)0.0177 (10)0.0008 (7)0.0000 (8)−0.0008 (9)
C30.0155 (9)0.0211 (9)0.0213 (11)−0.0005 (7)0.0013 (8)0.0010 (10)
C40.0191 (10)0.0209 (9)0.0173 (11)−0.0035 (7)0.0021 (8)−0.0006 (9)
C4A0.0188 (9)0.0181 (8)0.0177 (11)−0.0024 (7)0.0028 (8)0.0002 (9)
C50.0212 (10)0.0175 (8)0.0235 (11)−0.0027 (7)0.0028 (9)0.0009 (9)
C60.0245 (11)0.0167 (9)0.0267 (12)0.0018 (7)0.0039 (9)0.0013 (10)
C70.0185 (10)0.0230 (10)0.0244 (12)0.0018 (8)0.0010 (9)0.0030 (10)
C80.0179 (10)0.0197 (9)0.0233 (11)−0.0014 (7)−0.0008 (8)0.0002 (9)
C8A0.0172 (9)0.0161 (8)0.0189 (10)0.0002 (7)−0.0004 (8)0.0009 (8)
C210.0174 (9)0.0199 (9)0.0185 (11)0.0022 (7)−0.0011 (8)−0.0006 (9)
N2110.0160 (8)0.0163 (7)0.0231 (10)0.0013 (6)−0.0010 (7)−0.0011 (8)
C2120.0216 (10)0.0167 (9)0.0225 (11)0.0034 (7)−0.0021 (9)0.0005 (9)
C2130.0242 (10)0.0165 (9)0.0291 (13)−0.0021 (7)−0.0011 (9)0.0011 (10)
C2140.0190 (11)0.0238 (11)0.0263 (12)−0.0028 (8)−0.0009 (9)0.0022 (10)
C2150.0143 (9)0.0185 (9)0.0295 (12)0.0004 (7)−0.0004 (8)0.0008 (9)
Geometric parameters (Å, º) top
O1—C21.347 (2)C8—C8A1.392 (3)
O1—C8A1.380 (2)C8—H80.9500
O2—C211.230 (2)C21—N2111.340 (3)
O4—C41.239 (2)N211—C2151.480 (3)
C2—C31.349 (3)N211—C2121.481 (2)
C2—C211.517 (3)C212—C2131.518 (3)
C3—C41.452 (3)C212—H21G0.9900
C3—H30.9500C212—H21H0.9900
C4—C4A1.466 (3)C213—C2141.528 (3)
C4A—C8A1.395 (3)C213—H21E0.9900
C4A—C51.408 (3)C213—H21F0.9900
C5—C61.373 (3)C214—C2151.522 (3)
C5—H50.9500C214—H21C0.9900
C6—C71.403 (3)C214—H21D0.9900
C6—H60.9500C215—H21A0.9900
C7—C81.377 (3)C215—H21B0.9900
C7—H70.9500
C2—O1—C8A118.59 (15)O2—C21—C2117.10 (17)
O1—C2—C3124.10 (18)N211—C21—C2120.19 (17)
O1—C2—C21115.27 (16)C21—N211—C215130.26 (16)
C3—C2—C21120.60 (17)C21—N211—C212118.31 (16)
C2—C3—C4121.05 (19)C215—N211—C212111.34 (15)
C2—C3—H3119.5N211—C212—C213103.65 (16)
C4—C3—H3119.5N211—C212—H21G111.0
O4—C4—C3122.60 (19)C213—C212—H21G111.0
O4—C4—C4A122.99 (19)N211—C212—H21H111.0
C3—C4—C4A114.41 (17)C213—C212—H21H111.0
C8A—C4A—C5117.71 (18)H21G—C212—H21H109.0
C8A—C4A—C4120.01 (18)C212—C213—C214103.19 (17)
C5—C4A—C4122.28 (17)C212—C213—H21E111.1
C6—C5—C4A120.57 (18)C214—C213—H21E111.1
C6—C5—H5119.7C212—C213—H21F111.1
C4A—C5—H5119.7C214—C213—H21F111.1
C5—C6—C7120.39 (19)H21E—C213—H21F109.1
C5—C6—H6119.8C215—C214—C213103.63 (19)
C7—C6—H6119.8C215—C214—H21C111.0
C8—C7—C6120.3 (2)C213—C214—H21C111.0
C8—C7—H7119.8C215—C214—H21D111.0
C6—C7—H7119.8C213—C214—H21D111.0
C7—C8—C8A118.71 (19)H21C—C214—H21D109.0
C7—C8—H8120.6N211—C215—C214103.08 (17)
C8A—C8—H8120.6N211—C215—H21A111.1
O1—C8A—C8115.90 (17)C214—C215—H21A111.1
O1—C8A—C4A121.82 (17)N211—C215—H21B111.1
C8—C8A—C4A122.28 (18)C214—C215—H21B111.1
O2—C21—N211122.71 (18)H21A—C215—H21B109.1
C8A—O1—C2—C31.8 (3)C5—C4A—C8A—O1−179.9 (2)
C8A—O1—C2—C21179.99 (19)C4—C4A—C8A—O1−0.3 (3)
O1—C2—C3—C4−1.2 (4)C5—C4A—C8A—C80.4 (3)
C21—C2—C3—C4−179.3 (2)C4—C4A—C8A—C8180.0 (2)
C2—C3—C4—O4179.6 (2)O1—C2—C21—O2−163.5 (2)
C2—C3—C4—C4A−0.2 (3)C3—C2—C21—O214.8 (3)
O4—C4—C4A—C8A−178.9 (2)O1—C2—C21—N21116.3 (3)
C3—C4—C4A—C8A0.9 (3)C3—C2—C21—N211−165.4 (2)
O4—C4—C4A—C50.6 (4)O2—C21—N211—C215−175.3 (2)
C3—C4—C4A—C5−179.5 (2)C2—C21—N211—C2155.0 (4)
C8A—C4A—C5—C60.4 (4)O2—C21—N211—C2121.1 (3)
C4—C4A—C5—C6−179.1 (2)C2—C21—N211—C212−178.7 (2)
C4A—C5—C6—C7−0.9 (4)C21—N211—C212—C213171.5 (2)
C5—C6—C7—C80.6 (4)C215—N211—C212—C213−11.5 (3)
C6—C7—C8—C8A0.1 (3)N211—C212—C213—C21431.0 (2)
C2—O1—C8A—C8178.7 (2)C212—C213—C214—C215−39.4 (2)
C2—O1—C8A—C4A−1.0 (3)C21—N211—C215—C214163.8 (2)
C7—C8—C8A—O1179.6 (2)C212—N211—C215—C214−12.8 (3)
C7—C8—C8A—C4A−0.7 (3)C213—C214—C215—N21131.8 (2)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
C8—H8···O2i0.952.553.137 (3)121
C214—H21C···O4ii0.992.473.340 (3)146
Symmetry codes: (i) x+1/2, −y+1/2, z; (ii) −x+1, −y+1/2, z−1/2.
 

Acknowledgements

The authors thank the staff at the National Crystallographic Service, University of Southampton (Coles & Gale, 2012[Coles, S. J. & Gale, P. A. (2012). Chem. Sci. 3, 683-689.]), for the data collection, help and advice and the Foundation for Science and Technology (FCT) of Portugal (QUI/UI0081/2015). FC (SFRH/BPD/74491/2010) is supported by an FCT grant.

References

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ISSN: 2056-9890
Volume 71| Part 11| November 2015| Pages 1270-1277
https://doi.org/10.1107/S2056989015017958
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