research papers
AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine β-synthase) domains in the regulatory γ subunit. The structure of a CBS-domain pair from human AMPK γ1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.
Supporting information
PDB references: AMP complex, 2uv4, r2uv4sf; ZMP complex, 2uv5, r2uv5sf; R299Q AMP complex, 2uv6, r2uv6sf; R299G AMP complex, 2uv7, r2uv7sf