Buy article online - an online subscription or single-article purchase is required to access this article.
The title compound, C12H19NO, presents a two-dimensional hydrogen-bonding pattern, where amine and hydroxyl functionalities serve as both donors and acceptors.
Supporting information
CCDC reference: 287597
Key indicators
- Single-crystal X-ray study
- T = 296 K
- Mean (C-C) = 0.006 Å
- R factor = 0.053
- wR factor = 0.170
- Data-to-parameter ratio = 9.8
checkCIF/PLATON results
No syntax errors found
Alert level B
PLAT027_ALERT_3_B _diffrn_reflns_theta_full (too) Low ............ 24.99 Deg.
Alert level C
PLAT220_ALERT_2_C Large Non-Solvent C Ueq(max)/Ueq(min) ... 2.97 Ratio
PLAT222_ALERT_3_C Large Non-Solvent H Ueq(max)/Ueq(min) ... 3.30 Ratio
PLAT340_ALERT_3_C Low Bond Precision on C-C bonds (x 1000) Ang ... 6
PLAT352_ALERT_3_C Short N-H Bond (0.87A) N1 - H1B ... 0.75 Ang.
Alert level G
REFLT03_ALERT_4_G Please check that the estimate of the number of Friedel pairs is
correct. If it is not, please give the correct count in the
_publ_section_exptl_refinement section of the submitted CIF.
From the CIF: _diffrn_reflns_theta_max 24.99
From the CIF: _reflns_number_total 1327
Count of symmetry unique reflns 1338
Completeness (_total/calc) 99.18%
TEST3: Check Friedels for noncentro structure
Estimate of Friedel pairs measured 0
Fraction of Friedel pairs measured 0.000
Are heavy atom types Z>Si present no
0 ALERT level A = In general: serious problem
1 ALERT level B = Potentially serious problem
4 ALERT level C = Check and explain
1 ALERT level G = General alerts; check
0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data
1 ALERT type 2 Indicator that the structure model may be wrong or deficient
4 ALERT type 3 Indicator that the structure quality may be low
1 ALERT type 4 Improvement, methodology, query or suggestion
To a solution of 4-aminophenol (1 g, 9 mmol) in cyclohexanone was added finely powdered K2CO3 (2.53 g, 18 mmol) under an argon atmosphere. The mixture was refluxed for 2 h and then 1-bromohexane (1.82 g, 11 mmol) was added in small portions. The reaction was continued under reflux for 24 h and the mixture was then cooled and filtered to remove KBr and unreacted K2CO3. After evaporation of the solvent, the residue was dissolved in acetone and this solution was poured into hexane in order to precipitate unreacted 4-aminophenol and the solution reduced under reduced pressure at T < 323 K. This procedure was repeated until pure (I) was isolated as brown crystals (yield 0.82 g, 70%, m.p. 348 K). Analysis found: C 74.6, H 9.7, O 8.2, N 7.3%; calculated for C12H19NO: C 74.6, H 9.8, O 8.2, N 7.2%. 1H NMR (400 MHz, CDCl3): δ 0.89 (m, J = 8.8 Hz, 3H, CH3), 1.30 (m, J = 7.2, 6H, 3 × CH2), 1.58 (m, J = 6.8 Hz, 2H, CH2), 3.05 (m, J = 6.8 Hz, 2H, NCH2), 4.01 (s, 1H, OH), 6.55 (d, J = 8.4 Hz, 2H, Ph), 6.68 (d, J = 8.4 Hz, 2H, Ph).
The H atoms bonded to heteroatoms N1 and O1 were found in a difference map and refined with free coordinates and isotropic U parameters. H atoms bonded to C atoms were placed in idealized positions and refined as riding on their parent C atom [restrained C—H distances and isotropic Uiso(H) parameters: methylene 0.97 Å and 1.2Ueq(C); methyl 0.96 Å and 1.5Ueq(C); aromatic 0.93 Å and 1.2Ueq(C)]. In the absence of significant anomalous scattering effects, Friedel pairs were merged.
Data collection: XSCANS (Siemens, 1996); cell refinement: XSCANS; data reduction: XSCANS; program(s) used to solve structure: SHELXTL-Plus (Sheldrick, 1998); program(s) used to refine structure: SHELXTL-Plus; molecular graphics: SHELXTL-Plus; software used to prepare material for publication: SHELXTL-Plus.
4-(n-Hexylamino)phenol
top
Crystal data top
C12H19NO | Dx = 1.026 Mg m−3 |
Mr = 193.28 | Melting point: 348 K |
Orthorhombic, P212121 | Mo Kα radiation, λ = 0.71073 Å |
Hall symbol: P 2ac 2ab | Cell parameters from 55 reflections |
a = 4.7016 (6) Å | θ = 4.8–11.9° |
b = 10.1325 (14) Å | µ = 0.07 mm−1 |
c = 26.273 (3) Å | T = 296 K |
V = 1251.6 (3) Å3 | Prism, brown |
Z = 4 | 0.55 × 0.28 × 0.20 mm |
F(000) = 424 | |
Data collection top
Bruker P4 diffractometer | Rint = 0.048 |
Radiation source: fine-focus sealed tube, FN4 | θmax = 25.0°, θmin = 2.2° |
Graphite monochromator | h = −5→5 |
2θ/ω scans | k = −12→12 |
5524 measured reflections | l = −31→31 |
1327 independent reflections | 3 standard reflections every 97 reflections |
833 reflections with I > 2σ(I) | intensity decay: 3% |
Refinement top
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.053 | Hydrogen site location: See text |
wR(F2) = 0.170 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.04 | w = 1/[σ2(Fo2) + (0.1)2] where P = (Fo2 + 2Fc2)/3 |
1327 reflections | (Δ/σ)max < 0.001 |
136 parameters | Δρmax = 0.11 e Å−3 |
0 restraints | Δρmin = −0.17 e Å−3 |
Crystal data top
C12H19NO | V = 1251.6 (3) Å3 |
Mr = 193.28 | Z = 4 |
Orthorhombic, P212121 | Mo Kα radiation |
a = 4.7016 (6) Å | µ = 0.07 mm−1 |
b = 10.1325 (14) Å | T = 296 K |
c = 26.273 (3) Å | 0.55 × 0.28 × 0.20 mm |
Data collection top
Bruker P4 diffractometer | Rint = 0.048 |
5524 measured reflections | 3 standard reflections every 97 reflections |
1327 independent reflections | intensity decay: 3% |
833 reflections with I > 2σ(I) | |
Refinement top
R[F2 > 2σ(F2)] = 0.053 | 0 restraints |
wR(F2) = 0.170 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.04 | Δρmax = 0.11 e Å−3 |
1327 reflections | Δρmin = −0.17 e Å−3 |
136 parameters | |
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top | x | y | z | Uiso*/Ueq | |
O1 | 0.1149 (7) | 0.5685 (3) | 0.32994 (10) | 0.0833 (8) | |
H1A | −0.028 (11) | 0.542 (4) | 0.3307 (16) | 0.098 (18)* | |
N1 | 0.3464 (8) | 0.8998 (3) | 0.16515 (12) | 0.0754 (9) | |
H1B | 0.495 (10) | 0.925 (4) | 0.1686 (15) | 0.093 (15)* | |
C1 | 0.1688 (6) | 0.6457 (3) | 0.28791 (13) | 0.0659 (9) | |
C2 | 0.0336 (7) | 0.6269 (4) | 0.24204 (14) | 0.0756 (10) | |
H2A | −0.1008 | 0.5602 | 0.2387 | 0.091* | |
C3 | 0.0971 (7) | 0.7073 (3) | 0.20079 (13) | 0.0768 (10) | |
H3A | 0.0050 | 0.6933 | 0.1699 | 0.092* | |
C4 | 0.2953 (6) | 0.8079 (3) | 0.20483 (13) | 0.0660 (9) | |
C5 | 0.4315 (7) | 0.8240 (4) | 0.25173 (13) | 0.0744 (9) | |
H5A | 0.5675 | 0.8899 | 0.2555 | 0.089* | |
C6 | 0.3674 (7) | 0.7438 (3) | 0.29239 (14) | 0.0765 (9) | |
H6A | 0.4600 | 0.7564 | 0.3233 | 0.092* | |
C7 | 0.3220 (9) | 0.8555 (4) | 0.11289 (14) | 0.0878 (11) | |
H7A | 0.1276 | 0.8287 | 0.1061 | 0.105* | |
H7B | 0.4444 | 0.7797 | 0.1075 | 0.105* | |
C8 | 0.4068 (10) | 0.9663 (4) | 0.07655 (15) | 0.0992 (13) | |
H8A | 0.2828 | 1.0413 | 0.0823 | 0.119* | |
H8B | 0.5995 | 0.9938 | 0.0844 | 0.119* | |
C9 | 0.3925 (13) | 0.9294 (5) | 0.02187 (16) | 0.1203 (16) | |
H9A | 0.1998 | 0.9026 | 0.0137 | 0.144* | |
H9B | 0.5166 | 0.8545 | 0.0158 | 0.144* | |
C10 | 0.4811 (15) | 1.0442 (5) | −0.01366 (18) | 0.1311 (18) | |
H10A | 0.3490 | 1.1168 | −0.0091 | 0.157* | |
H10B | 0.6683 | 1.0750 | −0.0037 | 0.157* | |
C11 | 0.4880 (19) | 1.0084 (6) | −0.0677 (2) | 0.168 (2) | |
H11A | 0.2979 | 0.9838 | −0.0785 | 0.202* | |
H11B | 0.6101 | 0.9321 | −0.0721 | 0.202* | |
C12 | 0.593 (2) | 1.1177 (7) | −0.1009 (2) | 0.196 (3) | |
H12A | 0.5281 | 1.1040 | −0.1351 | 0.294* | |
H12B | 0.7975 | 1.1189 | −0.1004 | 0.294* | |
H12C | 0.5221 | 1.2005 | −0.0885 | 0.294* | |
Atomic displacement parameters (Å2) top | U11 | U22 | U33 | U12 | U13 | U23 |
O1 | 0.0817 (19) | 0.0811 (17) | 0.0870 (17) | −0.0060 (15) | −0.0013 (15) | 0.0114 (14) |
N1 | 0.077 (2) | 0.0712 (19) | 0.078 (2) | −0.0101 (17) | 0.0024 (16) | 0.0022 (16) |
C1 | 0.0611 (16) | 0.0558 (18) | 0.081 (2) | 0.0055 (16) | 0.0013 (17) | 0.0081 (18) |
C2 | 0.0687 (18) | 0.063 (2) | 0.095 (2) | −0.0132 (16) | −0.0019 (19) | 0.002 (2) |
C3 | 0.079 (2) | 0.074 (2) | 0.077 (2) | −0.0062 (19) | −0.0107 (19) | −0.005 (2) |
C4 | 0.0651 (16) | 0.0561 (17) | 0.077 (2) | 0.0022 (15) | 0.0044 (17) | −0.0031 (19) |
C5 | 0.0671 (17) | 0.070 (2) | 0.086 (2) | −0.0114 (17) | −0.005 (2) | −0.0006 (18) |
C6 | 0.0724 (19) | 0.075 (2) | 0.082 (2) | −0.0036 (19) | −0.0073 (19) | −0.005 (2) |
C7 | 0.102 (2) | 0.079 (2) | 0.082 (2) | −0.005 (2) | 0.011 (2) | −0.007 (2) |
C8 | 0.115 (3) | 0.099 (3) | 0.083 (3) | −0.010 (3) | 0.006 (2) | 0.002 (2) |
C9 | 0.151 (4) | 0.115 (3) | 0.095 (3) | −0.004 (4) | 0.016 (3) | −0.003 (3) |
C10 | 0.163 (5) | 0.135 (4) | 0.095 (3) | −0.009 (4) | 0.003 (3) | 0.006 (3) |
C11 | 0.226 (6) | 0.150 (5) | 0.127 (5) | −0.003 (6) | 0.019 (4) | 0.012 (4) |
C12 | 0.259 (9) | 0.187 (6) | 0.143 (5) | −0.027 (7) | 0.026 (6) | 0.058 (5) |
Geometric parameters (Å, º) top
O1—C1 | 1.377 (4) | C7—H7B | 0.9700 |
O1—H1A | 0.72 (5) | C8—C9 | 1.486 (6) |
N1—C4 | 1.419 (4) | C8—H8A | 0.9700 |
N1—C7 | 1.449 (5) | C8—H8B | 0.9700 |
N1—H1B | 0.75 (5) | C9—C10 | 1.549 (7) |
C1—C6 | 1.369 (4) | C9—H9A | 0.9700 |
C1—C2 | 1.376 (5) | C9—H9B | 0.9700 |
C2—C3 | 1.388 (5) | C10—C11 | 1.466 (8) |
C2—H2A | 0.9300 | C10—H10A | 0.9700 |
C3—C4 | 1.385 (4) | C10—H10B | 0.9700 |
C3—H3A | 0.9300 | C11—C12 | 1.494 (8) |
C4—C5 | 1.398 (4) | C11—H11A | 0.9700 |
C5—C6 | 1.376 (4) | C11—H11B | 0.9700 |
C5—H5A | 0.9300 | C12—H12A | 0.9600 |
C6—H6A | 0.9300 | C12—H12B | 0.9600 |
C7—C8 | 1.527 (5) | C12—H12C | 0.9600 |
C7—H7A | 0.9700 | | |
| | | |
C1—O1—H1A | 114 (3) | C9—C8—H8A | 108.7 |
C4—N1—C7 | 118.6 (3) | C7—C8—H8A | 108.7 |
C4—N1—H1B | 107 (3) | C9—C8—H8B | 108.7 |
C7—N1—H1B | 107 (3) | C7—C8—H8B | 108.7 |
C6—C1—C2 | 119.4 (3) | H8A—C8—H8B | 107.6 |
C6—C1—O1 | 118.0 (3) | C8—C9—C10 | 112.4 (4) |
C2—C1—O1 | 122.6 (3) | C8—C9—H9A | 109.1 |
C1—C2—C3 | 120.2 (3) | C10—C9—H9A | 109.1 |
C1—C2—H2A | 119.9 | C8—C9—H9B | 109.1 |
C3—C2—H2A | 119.9 | C10—C9—H9B | 109.1 |
C4—C3—C2 | 121.1 (3) | H9A—C9—H9B | 107.9 |
C4—C3—H3A | 119.5 | C11—C10—C9 | 113.8 (5) |
C2—C3—H3A | 119.5 | C11—C10—H10A | 108.8 |
C3—C4—C5 | 117.5 (3) | C9—C10—H10A | 108.8 |
C3—C4—N1 | 122.8 (3) | C11—C10—H10B | 108.8 |
C5—C4—N1 | 119.6 (3) | C9—C10—H10B | 108.8 |
C6—C5—C4 | 121.0 (3) | H10A—C10—H10B | 107.7 |
C6—C5—H5A | 119.5 | C10—C11—C12 | 112.9 (6) |
C4—C5—H5A | 119.5 | C10—C11—H11A | 109.0 |
C1—C6—C5 | 120.8 (3) | C12—C11—H11A | 109.0 |
C1—C6—H6A | 119.6 | C10—C11—H11B | 109.0 |
C5—C6—H6A | 119.6 | C12—C11—H11B | 109.0 |
N1—C7—C8 | 110.1 (3) | H11A—C11—H11B | 107.8 |
N1—C7—H7A | 109.6 | C11—C12—H12A | 109.5 |
C8—C7—H7A | 109.6 | C11—C12—H12B | 109.5 |
N1—C7—H7B | 109.6 | H12A—C12—H12B | 109.5 |
C8—C7—H7B | 109.6 | C11—C12—H12C | 109.5 |
H7A—C7—H7B | 108.2 | H12A—C12—H12C | 109.5 |
C9—C8—C7 | 114.1 (4) | H12B—C12—H12C | 109.5 |
| | | |
C6—C1—C2—C3 | −0.3 (5) | C2—C1—C6—C5 | 0.4 (5) |
O1—C1—C2—C3 | −179.7 (3) | O1—C1—C6—C5 | 179.8 (3) |
C1—C2—C3—C4 | −0.3 (5) | C4—C5—C6—C1 | 0.2 (5) |
C2—C3—C4—C5 | 0.9 (5) | C4—N1—C7—C8 | −175.8 (3) |
C2—C3—C4—N1 | −173.8 (3) | N1—C7—C8—C9 | 179.2 (4) |
C7—N1—C4—C3 | −33.8 (5) | C7—C8—C9—C10 | −179.8 (4) |
C7—N1—C4—C5 | 151.5 (3) | C8—C9—C10—C11 | 176.1 (7) |
C3—C4—C5—C6 | −0.9 (5) | C9—C10—C11—C12 | −176.0 (6) |
N1—C4—C5—C6 | 174.1 (3) | | |
Hydrogen-bond geometry (Å, º) top
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1A···N1i | 0.72 (5) | 2.08 (5) | 2.764 (5) | 158 (5) |
N1—H1B···O1ii | 0.75 (5) | 2.34 (5) | 3.058 (5) | 161 (4) |
Symmetry codes: (i) −x, y−1/2, −z+1/2; (ii) −x+1, y+1/2, −z+1/2. |
Experimental details
Crystal data |
Chemical formula | C12H19NO |
Mr | 193.28 |
Crystal system, space group | Orthorhombic, P212121 |
Temperature (K) | 296 |
a, b, c (Å) | 4.7016 (6), 10.1325 (14), 26.273 (3) |
V (Å3) | 1251.6 (3) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.07 |
Crystal size (mm) | 0.55 × 0.28 × 0.20 |
|
Data collection |
Diffractometer | Bruker P4 diffractometer |
Absorption correction | – |
No. of measured, independent and observed [I > 2σ(I)] reflections | 5524, 1327, 833 |
Rint | 0.048 |
(sin θ/λ)max (Å−1) | 0.594 |
|
Refinement |
R[F2 > 2σ(F2)], wR(F2), S | 0.053, 0.170, 1.04 |
No. of reflections | 1327 |
No. of parameters | 136 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.11, −0.17 |
Selected geometric parameters (Å, º) topO1—C1 | 1.377 (4) | C7—C8 | 1.527 (5) |
O1—H1A | 0.72 (5) | C8—C9 | 1.486 (6) |
N1—C4 | 1.419 (4) | C9—C10 | 1.549 (7) |
N1—C7 | 1.449 (5) | C10—C11 | 1.466 (8) |
N1—H1B | 0.75 (5) | C11—C12 | 1.494 (8) |
| | | |
C1—O1—H1A | 114 (3) | C4—N1—H1B | 107 (3) |
C4—N1—C7 | 118.6 (3) | C7—N1—H1B | 107 (3) |
Hydrogen-bond geometry (Å, º) top
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1A···N1i | 0.72 (5) | 2.08 (5) | 2.764 (5) | 158 (5) |
N1—H1B···O1ii | 0.75 (5) | 2.34 (5) | 3.058 (5) | 161 (4) |
Symmetry codes: (i) −x, y−1/2, −z+1/2; (ii) −x+1, y+1/2, −z+1/2. |
Subscribe to Acta Crystallographica Section E: Crystallographic Communications
The full text of this article is available to subscribers to the journal.
If you have already registered and are using a computer listed in your registration details, please email
support@iucr.org for assistance.
Secondary amines are ubiquitous in polymer synthesis, where they are used as monomer chain extenders and crosslinking agents (Herman et al., 1990; Choi et al., 2004). The title compound, (I), is an amphiphilic monomer belonging to this class of compounds, including an hydrophobic alkyl-chain moiety and a polar hydroxyl functionality. It was obtained by reacting 4-aminophenol with 1-bromohexane (see Experimental), demonstrating that, as expected, the amine functionality is more reactive than the hydroxy group when 4-aminophenol undergoes an SN2 reaction with primary alkyl halides.
The asymmetric unit of (I) consists of one molecule in a general position with the expected geometry (Fig. 1 and Table 1). O—H and N—H bond lengths are short [0.72 (5) and 0.75 (5) Å, respectively] compared to those found, for example, in 4-aminophenol [0.87 and 0.90–0.96 Å, respectively; Ermer & Eling, 1994]. These groups are involved in a network of hydrogen bonds of moderate strength (Table 2); hydroxyl and amine functionalities serve both as donor and acceptor groups, forming a directed two-membered chain ···O—H···N—H···O—H··· running along the short axis [100]. The complete network has a two-dimensional pattern (Fig. 2), giving an arrangement which avoids π–π interactions; the dihedral angle between two adjacent phenol rings belonging to two hydrogen-bonded molecules is 78.99 (9)° (symmetry code: 1 − x, 1/2 + y, 1 − z). The crystal structure is based on segregated stacks of aryl groups and alkyl groups, parallel to the [100] axis (Fig. 2, inset).