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ISSN: 2056-9890

5-Ethyl-2-(4-fluoro­phen­yl)-4-phen­­oxy-1H-pyrazol-3(2H)-one

aX-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia, and bOrganic Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, India
*Correspondence e-mail: hkfun@usm.my

(Received 5 January 2011; accepted 6 January 2011; online 22 January 2011)

In the title compound, C17H15FN2O2, the essentially planar pyrazole ring [maximum deviation = 0.026 (1) Å] makes dihedral angles of 72.06 (7) and 33.05 (7)°, with the phenyl and fluoro­benzene rings, respectively. The dihedral angle between the two six-membered rings is 87.88 (7)°. In the crystal, inter­molecular N—H⋯O and C—H⋯F hydrogen bonds link the mol­ecules into layers lying parallel to the bc plane.

Related literature

For pyrazole derivatives and their microbial activity, see: Ragavan et al. (2009[Ragavan, R. V., Vijayakumar, V. & Kumari, N. S. (2009). Eur. J. Med. Chem. 44, 3852-3857.], 2010[Ragavan, R. V., Vijayakumar, V. & Kumari, N. S. (2010). Eur. J. Med. Chem. 45, 1173-1180.]). For the synthesis, see: Ragavan et al. (2009[Ragavan, R. V., Vijayakumar, V. & Kumari, N. S. (2009). Eur. J. Med. Chem. 44, 3852-3857.]). For related structures, see: Shahani et al. (2009[Shahani, T., Fun, H.-K., Ragavan, R. V., Vijayakumar, V. & Sarveswari, S. (2009). Acta Cryst. E65, o3249-o3250.], 2010a[Shahani, T., Fun, H.-K., Ragavan, R. V., Vijayakumar, V. & Sarveswari, S. (2010a). Acta Cryst. E66, o142-o143.],b[Shahani, T., Fun, H.-K., Ragavan, R. V., Vijayakumar, V. & Sarveswari, S. (2010b). Acta Cryst. E66, o1357-o1358.]). For hydrogen-bond motifs, see: Bernstein et al. (1995[Bernstein, J., Davis, R. E., Shimoni, L. & Chang, N.-L. (1995). Angew. Chem. Int. Ed. Engl. 34, 1555-1573.]). For bond-length data, see: Allen et al. (1987[Allen, F. H., Kennard, O., Watson, D. G., Brammer, L., Orpen, A. G. & Taylor, R. (1987). J. Chem. Soc. Perkin Trans. 2, pp. S1-19.]). For the stability of the temperature controller used in the data collection, see: Cosier & Glazer (1986[Cosier, J. & Glazer, A. M. (1986). J. Appl. Cryst. 19, 105-107.]).

[Scheme 1]

Experimental

Crystal data
  • C17H15FN2O2

  • Mr = 298.31

  • Monoclinic, P 21 /c

  • a = 15.332 (2) Å

  • b = 8.6833 (14) Å

  • c = 11.6066 (19) Å

  • β = 109.916 (3)°

  • V = 1452.8 (4) Å3

  • Z = 4

  • Mo Kα radiation

  • μ = 0.10 mm−1

  • T = 100 K

  • 0.55 × 0.14 × 0.08 mm

Data collection
  • Bruker APEXII DUO CCD diffractometer

  • Absorption correction: multi-scan (SADABS; Bruker, 2009[Bruker (2009). APEX2, SAINT and SADABS. Bruker AXS Inc., Madison, Wiscosin, USA.]) Tmin = 0.947, Tmax = 0.992

  • 12927 measured reflections

  • 4247 independent reflections

  • 3207 reflections with I > 2σ(I)

  • Rint = 0.036

Refinement
  • R[F2 > 2σ(F2)] = 0.044

  • wR(F2) = 0.119

  • S = 1.05

  • 4247 reflections

  • 204 parameters

  • H atoms treated by a mixture of independent and constrained refinement

  • Δρmax = 0.34 e Å−3

  • Δρmin = −0.24 e Å−3

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A D—H H⋯A DA D—H⋯A
N2—H1N2⋯O2i 0.899 (18) 1.803 (18) 2.6865 (14) 167.1 (16)
C11—H11A⋯F1ii 0.93 2.52 3.3441 (16) 147
Symmetry codes: (i) [x, -y+{\script{3\over 2}}, z-{\script{1\over 2}}]; (ii) [-x+1, y-{\script{1\over 2}}, -z+{\script{1\over 2}}].

Data collection: APEX2 (Bruker, 2009[Bruker (2009). APEX2, SAINT and SADABS. Bruker AXS Inc., Madison, Wiscosin, USA.]); cell refinement: SAINT (Bruker, 2009[Bruker (2009). APEX2, SAINT and SADABS. Bruker AXS Inc., Madison, Wiscosin, USA.]); data reduction: SAINT; program(s) used to solve structure: SHELXTL (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL; software used to prepare material for publication: SHELXTL and PLATON (Spek, 2009[Spek, A. L. (2009). Acta Cryst. D65, 148-155.]).

Supporting information


Comment top

Antibacterial and antifungal activities of the azoles are most widely studied and some of them are in clinical practice as anti-microbial agents. However, the azole-resistant strain had led to the development of new antimicrobial compounds. In particular pyrazole derivatives are extensively studied and used as antimicrobial agents. Pyrazole is an important class of heterocyclic compounds and many pyrazole derivatives are reported to have the broad spectrum of biological properties, such as anti-inflammatory, antifungal, herbicidal,anti-tumour, cytotoxic, molecular modelling, and antiviral activities. Pyrazole derivatives also act as antiangiogenic agents, A3 adenosine receptor antagonists, neuropeptide YY5 receptor antagonists, kinase inhibitor for treatment of type 2 diabetes, hyperlipidemia, obesity, and thrombopiotinmimetics. Recently urea derivatives of pyrazoles have been reported as potent inhibitors of p38 kinase. Since the high electronegativity of halogens (particularly chlorine and fluorine) in the aromatic part of the drug molecules play an important role in enhancing their biological activity, we are interested to have 4-fluoro or 4-chloro substitution in the aryls of 1,5-diaryl pyrazoles. As part of our on-going research aiming the synthesis of new antimicrobial compounds, we have reported the synthesis of novel pyrazole derivatives and their microbial activities (Ragavan et al., 2009; 2010). The structure of the title compound, (I), is presented here.

In the title compound (Fig. 1), the molecule consists of two phenyl (C10—C15 and C1—C6) and one pyrazole (N1/N2/C7—C9) rings, all rings are essentially planar. The pyrazole ring (maximum deviation of 0.026 (1) Å at atom N1) makes dihedral angles of 72.06 (7) and 33.05 (7)°, with phenyl (C10—C15) and fluoro substituted phenyl (C1—C6) rings, respectively. The dihedral angle between the two six-membered rings,(C1—C6) and (C10—C15), is 87.88 (7)°. The bond lengths (Allen et al., 1987) and angles are within normal ranges and are comparable to the closely related structures (Shahani et al.,2009; 2010a,b).

In the crystal (Fig. 2), intermolecular N2–H1N2···O2 and C11–H11A···F1 (Table 1) hydrogen bonds link the molecules into two-dimensional arrays parallel to the bc plane.

Related literature top

For pyrazole derivatives and their microbial activity, see: Ragavan et al. (2009, 2010). For the synthesis, see: Ragavan et al. (2009). For related structures, see: Shahani et al. (2009, 2010a,b). For hydrogen-bond motifs, see: Bernstein et al. (1995). For bond-length data, see: Allen et al. (1987). For the stability of the temperature controller used in the data collection, see: Cosier & Glazer (1986).

Experimental top

The compound was synthesized using the literature method (Ragavan et al.,2009) and recrystallized using an ethanol-chloroform 1:1 mixture to yield colourless needles of (I). Yield: 61%. M.p.: 441 K.

Refinement top

The hydrogen atom bound to the N2 atom was located in a difference map and allow to refine freely [N–H = 0.899 (18) Å]. All other H atoms were positioned geometrically [range of C–H = 0.93 to 0.97 Å] with Uiso(H) = 1.2 or 1.5 Ueq(C). A rotating-group model was applied for the methyl group

Computing details top

Data collection: APEX2 (Bruker, 2009); cell refinement: SAINT (Bruker, 2009); data reduction: SAINT (Bruker, 2009); program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008) and PLATON (Spek, 2009).

Figures top
[Figure 1] Fig. 1. The molecular structure of (I), showing 50% probability displacement ellipsoids.
[Figure 2] Fig. 2. The crystal packing of (I), viewed along b axis. Intermolecular hydrogen bonds linked the molecules into two-dimensional arrays parallel to the bc plane. H atoms not involved in hydrogen bonds (dashed lines) have been omitted for clarity.
5-Ethyl-2-(4-fluorophenyl)-4-phenoxy-1H-pyrazol-3(2H)-one top
Crystal data top
C17H15FN2O2F(000) = 624
Mr = 298.31Dx = 1.364 Mg m3
Monoclinic, P21/cMo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybcCell parameters from 2971 reflections
a = 15.332 (2) Åθ = 3.0–33.0°
b = 8.6833 (14) ŵ = 0.10 mm1
c = 11.6066 (19) ÅT = 100 K
β = 109.916 (3)°Needle, colourless
V = 1452.8 (4) Å30.55 × 0.14 × 0.08 mm
Z = 4
Data collection top
Bruker APEXII DUO CCD
diffractometer
4247 independent reflections
Radiation source: fine-focus sealed tube3207 reflections with I > 2σ(I)
Graphite monochromatorRint = 0.036
ϕ and ω scansθmax = 30.0°, θmin = 3.0°
Absorption correction: multi-scan
(SADABS; Bruker, 2009)
h = 2120
Tmin = 0.947, Tmax = 0.992k = 129
12927 measured reflectionsl = 1616
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.044Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.119H atoms treated by a mixture of independent and constrained refinement
S = 1.05 w = 1/[σ2(Fo2) + (0.047P)2 + 0.4776P]
where P = (Fo2 + 2Fc2)/3
4247 reflections(Δ/σ)max < 0.001
204 parametersΔρmax = 0.34 e Å3
0 restraintsΔρmin = 0.24 e Å3
Crystal data top
C17H15FN2O2V = 1452.8 (4) Å3
Mr = 298.31Z = 4
Monoclinic, P21/cMo Kα radiation
a = 15.332 (2) ŵ = 0.10 mm1
b = 8.6833 (14) ÅT = 100 K
c = 11.6066 (19) Å0.55 × 0.14 × 0.08 mm
β = 109.916 (3)°
Data collection top
Bruker APEXII DUO CCD
diffractometer
4247 independent reflections
Absorption correction: multi-scan
(SADABS; Bruker, 2009)
3207 reflections with I > 2σ(I)
Tmin = 0.947, Tmax = 0.992Rint = 0.036
12927 measured reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0440 restraints
wR(F2) = 0.119H atoms treated by a mixture of independent and constrained refinement
S = 1.05Δρmax = 0.34 e Å3
4247 reflectionsΔρmin = 0.24 e Å3
204 parameters
Special details top

Experimental. The crystal was placed in the cold stream of an Oxford Cyrosystems Cobra open-flow nitrogen cryostat (Cosier & Glazer, 1986) operating at 100.0 (1) K.

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
F10.77686 (5)0.90535 (11)0.09196 (7)0.0332 (2)
O10.22938 (6)0.55499 (11)0.07275 (8)0.0226 (2)
O20.40598 (6)0.72722 (11)0.20071 (7)0.0243 (2)
N10.41488 (7)0.72695 (13)0.00442 (8)0.0187 (2)
N20.36358 (7)0.66422 (13)0.10812 (9)0.0192 (2)
C10.55898 (8)0.70430 (15)0.03872 (10)0.0191 (2)
H1A0.53200.62890.09690.023*
C20.64946 (9)0.75124 (16)0.01831 (11)0.0215 (3)
H2A0.68360.70980.06340.026*
C30.68736 (8)0.86072 (16)0.07039 (11)0.0222 (3)
C40.63952 (9)0.92659 (15)0.13937 (11)0.0215 (3)
H4A0.66770.99920.19940.026*
C50.54850 (8)0.88198 (15)0.11691 (10)0.0200 (3)
H5A0.51420.92610.16070.024*
C60.50869 (8)0.77049 (14)0.02820 (10)0.0172 (2)
C70.37115 (8)0.69697 (15)0.08861 (10)0.0187 (2)
C80.28708 (8)0.62287 (15)0.01905 (10)0.0190 (2)
C90.28418 (8)0.60586 (15)0.09962 (10)0.0190 (2)
C100.14644 (8)0.62813 (16)0.06414 (11)0.0204 (3)
C110.10224 (9)0.56911 (18)0.14043 (11)0.0254 (3)
H11A0.12840.48810.19330.030*
C120.01814 (10)0.6329 (2)0.13677 (13)0.0337 (4)
H12A0.01200.59470.18800.040*
C130.02094 (10)0.7526 (2)0.05755 (14)0.0378 (4)
H13A0.07720.79500.05540.045*
C140.02428 (10)0.8092 (2)0.01883 (13)0.0330 (3)
H14A0.00230.88920.07270.040*
C150.10888 (9)0.74771 (17)0.01581 (11)0.0252 (3)
H15A0.13940.78630.06650.030*
C160.21135 (9)0.53400 (17)0.20637 (11)0.0246 (3)
H16A0.16730.61270.24910.030*
H16B0.17810.45780.17640.030*
C170.25005 (10)0.45693 (18)0.29685 (12)0.0282 (3)
H17A0.20090.40510.35900.042*
H17B0.29680.38360.25420.042*
H17C0.27690.53360.33420.042*
H1N20.3689 (12)0.706 (2)0.1764 (16)0.035 (4)*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
F10.0199 (4)0.0497 (6)0.0311 (4)0.0092 (4)0.0103 (3)0.0079 (4)
O10.0193 (4)0.0301 (5)0.0232 (4)0.0039 (4)0.0136 (3)0.0076 (4)
O20.0251 (4)0.0367 (6)0.0138 (4)0.0009 (4)0.0100 (3)0.0019 (3)
N10.0179 (5)0.0274 (6)0.0124 (4)0.0018 (4)0.0071 (4)0.0017 (4)
N20.0192 (5)0.0275 (6)0.0120 (4)0.0024 (4)0.0067 (4)0.0009 (4)
C10.0208 (5)0.0212 (6)0.0166 (5)0.0005 (5)0.0080 (4)0.0013 (4)
C20.0211 (6)0.0265 (7)0.0200 (5)0.0019 (5)0.0109 (5)0.0001 (5)
C30.0179 (5)0.0281 (7)0.0202 (5)0.0016 (5)0.0060 (4)0.0021 (5)
C40.0220 (6)0.0243 (6)0.0174 (5)0.0009 (5)0.0059 (4)0.0019 (4)
C50.0217 (6)0.0237 (6)0.0159 (5)0.0031 (5)0.0082 (4)0.0002 (4)
C60.0174 (5)0.0209 (6)0.0143 (5)0.0013 (4)0.0067 (4)0.0027 (4)
C70.0203 (5)0.0224 (6)0.0160 (5)0.0042 (5)0.0097 (4)0.0019 (4)
C80.0178 (5)0.0244 (6)0.0177 (5)0.0016 (5)0.0099 (4)0.0023 (4)
C90.0181 (5)0.0225 (6)0.0177 (5)0.0016 (5)0.0078 (4)0.0015 (4)
C100.0163 (5)0.0283 (7)0.0175 (5)0.0002 (5)0.0070 (4)0.0029 (4)
C110.0191 (6)0.0394 (8)0.0193 (6)0.0026 (5)0.0087 (5)0.0010 (5)
C120.0207 (6)0.0588 (11)0.0263 (6)0.0031 (7)0.0142 (5)0.0045 (6)
C130.0218 (6)0.0590 (11)0.0344 (7)0.0097 (7)0.0119 (6)0.0071 (7)
C140.0295 (7)0.0401 (9)0.0288 (7)0.0129 (6)0.0090 (6)0.0007 (6)
C150.0246 (6)0.0314 (7)0.0221 (6)0.0039 (6)0.0110 (5)0.0006 (5)
C160.0211 (6)0.0321 (7)0.0207 (6)0.0027 (5)0.0071 (5)0.0019 (5)
C170.0301 (7)0.0347 (8)0.0194 (6)0.0042 (6)0.0078 (5)0.0055 (5)
Geometric parameters (Å, º) top
F1—C31.3644 (14)C8—C91.3708 (16)
O1—C81.3763 (15)C9—C161.4928 (17)
O1—C101.3941 (15)C10—C151.3809 (18)
O2—C71.2544 (14)C10—C111.3837 (18)
N1—C71.3851 (15)C11—C121.3907 (19)
N1—N21.3862 (13)C11—H11A0.9300
N1—C61.4202 (16)C12—C131.382 (2)
N2—C91.3529 (16)C12—H12A0.9300
N2—H1N20.899 (18)C13—C141.388 (2)
C1—C21.3866 (17)C13—H13A0.9300
C1—C61.3915 (17)C14—C151.3922 (19)
C1—H1A0.9300C14—H14A0.9300
C2—C31.3761 (18)C15—H15A0.9300
C2—H2A0.9300C16—C171.5255 (19)
C3—C41.3806 (18)C16—H16A0.9700
C4—C51.3848 (17)C16—H16B0.9700
C4—H4A0.9300C17—H17A0.9600
C5—C61.3934 (17)C17—H17B0.9600
C5—H5A0.9300C17—H17C0.9600
C7—C81.4206 (17)
C8—O1—C10118.93 (10)N2—C9—C16122.23 (11)
C7—N1—N2109.59 (10)C8—C9—C16129.65 (12)
C7—N1—C6127.91 (9)C15—C10—C11121.70 (12)
N2—N1—C6119.98 (9)C15—C10—O1123.51 (11)
C9—N2—N1108.32 (9)C11—C10—O1114.77 (11)
C9—N2—H1N2124.6 (11)C10—C11—C12118.95 (13)
N1—N2—H1N2118.8 (11)C10—C11—H11A120.5
C2—C1—C6119.70 (11)C12—C11—H11A120.5
C2—C1—H1A120.1C13—C12—C11120.48 (14)
C6—C1—H1A120.1C13—C12—H12A119.8
C3—C2—C1118.28 (12)C11—C12—H12A119.8
C3—C2—H2A120.9C12—C13—C14119.58 (14)
C1—C2—H2A120.9C12—C13—H13A120.2
F1—C3—C2118.39 (12)C14—C13—H13A120.2
F1—C3—C4118.40 (11)C13—C14—C15120.79 (14)
C2—C3—C4123.20 (12)C13—C14—H14A119.6
C3—C4—C5118.38 (12)C15—C14—H14A119.6
C3—C4—H4A120.8C10—C15—C14118.50 (13)
C5—C4—H4A120.8C10—C15—H15A120.8
C4—C5—C6119.55 (11)C14—C15—H15A120.8
C4—C5—H5A120.2C9—C16—C17113.48 (11)
C6—C5—H5A120.2C9—C16—H16A108.9
C1—C6—C5120.86 (11)C17—C16—H16A108.9
C1—C6—N1119.90 (11)C9—C16—H16B108.9
C5—C6—N1119.23 (11)C17—C16—H16B108.9
O2—C7—N1123.71 (11)H16A—C16—H16B107.7
O2—C7—C8131.88 (11)C16—C17—H17A109.5
N1—C7—C8104.34 (10)C16—C17—H17B109.5
C9—C8—O1127.09 (11)H17A—C17—H17B109.5
C9—C8—C7109.42 (11)C16—C17—H17C109.5
O1—C8—C7122.36 (10)H17A—C17—H17C109.5
N2—C9—C8108.11 (10)H17B—C17—H17C109.5
C7—N1—N2—C94.94 (14)O2—C7—C8—C9174.87 (14)
C6—N1—N2—C9168.32 (11)N1—C7—C8—C92.11 (14)
C6—C1—C2—C31.35 (18)O2—C7—C8—O16.2 (2)
C1—C2—C3—F1179.00 (11)N1—C7—C8—O1170.74 (11)
C1—C2—C3—C40.4 (2)N1—N2—C9—C83.48 (14)
F1—C3—C4—C5179.60 (11)N1—N2—C9—C16177.94 (12)
C2—C3—C4—C51.0 (2)O1—C8—C9—N2167.13 (12)
C3—C4—C5—C61.43 (18)C7—C8—C9—N20.83 (15)
C2—C1—C6—C50.93 (18)O1—C8—C9—C1611.3 (2)
C2—C1—C6—N1177.66 (11)C7—C8—C9—C16179.27 (13)
C4—C5—C6—C10.49 (18)C8—O1—C10—C1513.96 (18)
C4—C5—C6—N1179.09 (11)C8—O1—C10—C11167.62 (11)
C7—N1—C6—C1137.38 (13)C15—C10—C11—C120.4 (2)
N2—N1—C6—C122.65 (17)O1—C10—C11—C12178.89 (12)
C7—N1—C6—C544.01 (18)C10—C11—C12—C130.4 (2)
N2—N1—C6—C5155.96 (11)C11—C12—C13—C140.1 (2)
N2—N1—C7—O2173.06 (12)C12—C13—C14—C150.6 (2)
C6—N1—C7—O211.4 (2)C11—C10—C15—C140.1 (2)
N2—N1—C7—C84.24 (13)O1—C10—C15—C14178.25 (12)
C6—N1—C7—C8165.94 (12)C13—C14—C15—C100.6 (2)
C10—O1—C8—C987.43 (16)N2—C9—C16—C1730.45 (18)
C10—O1—C8—C7106.04 (13)C8—C9—C16—C17147.80 (14)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N2—H1N2···O2i0.899 (18)1.803 (18)2.6865 (14)167.1 (16)
C11—H11A···F1ii0.932.523.3441 (16)147
Symmetry codes: (i) x, y+3/2, z1/2; (ii) x+1, y1/2, z+1/2.

Experimental details

Crystal data
Chemical formulaC17H15FN2O2
Mr298.31
Crystal system, space groupMonoclinic, P21/c
Temperature (K)100
a, b, c (Å)15.332 (2), 8.6833 (14), 11.6066 (19)
β (°) 109.916 (3)
V3)1452.8 (4)
Z4
Radiation typeMo Kα
µ (mm1)0.10
Crystal size (mm)0.55 × 0.14 × 0.08
Data collection
DiffractometerBruker APEXII DUO CCD
diffractometer
Absorption correctionMulti-scan
(SADABS; Bruker, 2009)
Tmin, Tmax0.947, 0.992
No. of measured, independent and
observed [I > 2σ(I)] reflections
12927, 4247, 3207
Rint0.036
(sin θ/λ)max1)0.703
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.044, 0.119, 1.05
No. of reflections4247
No. of parameters204
H-atom treatmentH atoms treated by a mixture of independent and constrained refinement
Δρmax, Δρmin (e Å3)0.34, 0.24

Computer programs: APEX2 (Bruker, 2009), SAINT (Bruker, 2009), SHELXTL (Sheldrick, 2008) and PLATON (Spek, 2009).

Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
N2—H1N2···O2i0.899 (18)1.803 (18)2.6865 (14)167.1 (16)
C11—H11A···F1ii0.932.523.3441 (16)147
Symmetry codes: (i) x, y+3/2, z1/2; (ii) x+1, y1/2, z+1/2.
 

Footnotes

Thomson Reuters ResearcherID: A-3561-2009.

Acknowledgements

HKF and TSH thank Universiti Sains Malaysia (USM) for the Research University Grant (1001/PFIZIK/811160). TSH also thanks USM for the award of a research fellowship. VV is grateful to the DST–India for funding through the Young Scientist Scheme (Fast Track Proposal).

References

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