Acta Crystallographica Section D

Biological Crystallography

Volume 58, Part 12 (December 2002)


research papers



Acta Cryst. (2002). D58, 2082-2086    [ doi:10.1107/S0907444902016360 ]

Statistical density modification with non-crystallographic symmetry

T. C. Terwilliger

Abstract: Statistical density modification is a technique for phase improvement through a calculation of the posterior probability of the phases, given experimental phase information and expectations about features of the electron-density map. The technique can take advantage of both estimates of electron density in the map and uncertainties or probability distributions for those estimates. For crystals with non-crystallographic symmetry (NCS), this allows the use of the expected similarity of electron density at NCS-related points without requiring an implicit assumption that these regions are identical.

Keywords: density modification; non-crystallographic symmetry.

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