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The stereogenic centre in the title compound, C14H19NO4S2, is substituted with a dithiocarbonate, an ethyloximino and a 3,4-dimethoxyphenyl group, as well as an H atom. Tandem hydrogen-bonding occurs between enantiomers to produce dimers, in which the oxime H atom serves as donor toward the oxime N atom of an adjacent molecule.
Supporting information
CCDC reference: 287557
Key indicators
- Single-crystal X-ray study
- T = 299 K
- Mean (C-C) = 0.006 Å
- R factor = 0.071
- wR factor = 0.220
- Data-to-parameter ratio = 16.4
checkCIF/PLATON results
No syntax errors found
Alert level A
PLAT029_ALERT_3_A _diffrn_measured_fraction_theta_full Low ....... 0.92
| Author Response: I wish to point out that the data set only has a completeness of 95%
up to theta=22.5\%. Up to theta =26.4\%, the completeness reaches a value of
91.5%, which still is considered to be sufficient in order to
unambigiously solve the structure and refine the structure model reliably.
|
Alert level B
PLAT417_ALERT_2_B Short Inter D-H..H-D H1 .. H1 .. 2.00 Ang.
Alert level C
ABSTM02_ALERT_3_C The ratio of Tmax/Tmin expected RT(exp) is > 1.10
Absorption corrections should be applied.
Tmin and Tmax expected: 0.809 0.924
RT(exp) = 1.142
REFLT03_ALERT_3_C Reflection count < 95% complete
From the CIF: _diffrn_reflns_theta_max 26.37
From the CIF: _diffrn_reflns_theta_full 26.37
From the CIF: _reflns_number_total 3161
TEST2: Reflns within _diffrn_reflns_theta_max
Count of symmetry unique reflns 3452
Completeness (_total/calc) 91.57%
PLAT022_ALERT_3_C Ratio Unique / Expected Reflections too Low .... 0.92
PLAT057_ALERT_3_C Correction for Absorption Required RT(exp) ... 1.15
PLAT063_ALERT_3_C Crystal Probably too Large for Beam Size ....... 0.66 mm
PLAT125_ALERT_4_C No _symmetry_space_group_name_Hall Given ....... ?
PLAT340_ALERT_3_C Low Bond Precision on C-C bonds (x 1000) Ang ... 6
PLAT380_ALERT_4_C Check Incorrectly? Oriented X(sp2)-Methyl Moiety C2
PLAT790_ALERT_4_C Centre of Gravity not Within Unit Cell: Resd. # 1
C14 H19 N O4 S2
1 ALERT level A = In general: serious problem
1 ALERT level B = Potentially serious problem
9 ALERT level C = Check and explain
0 ALERT level G = General alerts; check
0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data
1 ALERT type 2 Indicator that the structure model may be wrong or deficient
7 ALERT type 3 Indicator that the structure quality may be low
3 ALERT type 4 Improvement, methodology, query or suggestion
Crystals of (I) suitable for X-ray diffraction were obtained by slowly concentrating a saturated solution of (I) in CH2Cl2 at 298 K. (m.p. 375–377 K). Rf = 0.35 [SiO2, petroleum ether/Et2O = 2/1 (v/v)]. Analysis, calculated for C14H19NO4S2: C 51.04, H 5.81, N 4.25, S 19.47%; found: C 51.21, H 5.63, N 4.33, S 19.31%. MS (70 eV, EI): m/z (%) 329 (1), 300 (3), 208 (100), 191 (33), 182 (30). 1H NMR (CDCl3, 400 MHz, δ, p.p.m.): 1.38 (t, 3H, J = 7.2 Hz), 1.91 (s, 3H), 3.86 (s, 3H), 3.87 (s, 3H), 4.61 (q, 2H, J = 7.1 Hz), 5.50 (s, 1H), 6.81 (d, 1H, J = 8.2 Hz), 6.88 (d, 1H, J = 1.9 Hz), 6.93 (dd, 1H, J = 1.9, 8.2 Hz). 13C NMR (CDCl3, 100 MHz, δ, p.p.m.): 13.9, 14.1, 56.3, 56.4, 58.6, 70.6, 111.6, 112.0, 121.5, 128.8, 149.4, 156.4, 213.6 (C═S).
Atom H1 was located in a difference Fourier map and its atomic coordinates were refined, with Uiso(H1) = 1.2Ueq(O1). All other H atoms were positioned geometrically and treated as riding atoms, with C—H distances in the range 0.93–0.96 Å and with Uiso(H) = 1.2Ueq(C).
Data collection: CrysAlis CCD (Oxford Diffraction, 2002); cell refinement: CrysAlis RED (Oxford Diffraction, 2002); data reduction: CrysAlis RED; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: PLATON2002 (Spek, 1990, 2003) and ORTEP-3 (Farrugia, 1997,
2005); software used to prepare material for publication: SHELXL97.
O-Ethyl-
S-[1-(3,4-dimethoxyphenyl)-2-oximinopropyl]dithiocarbonate
top
Crystal data top
C14H19NO4S2 | Dx = 1.297 Mg m−3 |
Mr = 329.42 | Melting point: 375 K |
Monoclinic, P21/c | Mo Kα radiation, λ = 0.71073 Å |
a = 9.114 (2) Å | Cell parameters from 1190 reflections |
b = 7.319 (2) Å | θ = 2.6–22.0° |
c = 25.575 (6) Å | µ = 0.33 mm−1 |
β = 98.66 (2)° | T = 299 K |
V = 1686.5 (7) Å3 | Prism, light brown |
Z = 4 | 0.66 × 0.60 × 0.24 mm |
F(000) = 696 | |
Data collection top
Oxford Diffraction Xcalibur CCD diffractometer | 1809 reflections with I > 2σ(I) |
Radiation source: fine-focus sealed tube | Rint = 0.047 |
Graphite monochromator | θmax = 26.4°, θmin = 4.1° |
Detector resolution: Sapphire CCD detector pixels mm-1 | h = −11→11 |
Rotation method data acquisition using phi scans | k = −9→8 |
4733 measured reflections | l = −31→31 |
3161 independent reflections | |
Refinement top
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.071 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.220 | H atoms treated by a mixture of independent and constrained refinement |
S = 0.93 | w = 1/[σ2(Fo2) + (0.124P)2 + 1.166P] where P = (Fo2 + 2Fc2)/3 |
3161 reflections | (Δ/σ)max = 0.002 |
193 parameters | Δρmax = 0.40 e Å−3 |
0 restraints | Δρmin = −0.42 e Å−3 |
Crystal data top
C14H19NO4S2 | V = 1686.5 (7) Å3 |
Mr = 329.42 | Z = 4 |
Monoclinic, P21/c | Mo Kα radiation |
a = 9.114 (2) Å | µ = 0.33 mm−1 |
b = 7.319 (2) Å | T = 299 K |
c = 25.575 (6) Å | 0.66 × 0.60 × 0.24 mm |
β = 98.66 (2)° | |
Data collection top
Oxford Diffraction Xcalibur CCD diffractometer | 1809 reflections with I > 2σ(I) |
4733 measured reflections | Rint = 0.047 |
3161 independent reflections | |
Refinement top
R[F2 > 2σ(F2)] = 0.071 | 0 restraints |
wR(F2) = 0.220 | H atoms treated by a mixture of independent and constrained refinement |
S = 0.93 | Δρmax = 0.40 e Å−3 |
3161 reflections | Δρmin = −0.42 e Å−3 |
193 parameters | |
Special details top
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top | x | y | z | Uiso*/Ueq | |
C1 | −0.0010 (4) | 0.8794 (6) | 0.07504 (14) | 0.0523 (9) | |
C2 | 0.3430 (5) | 1.4444 (5) | 0.04715 (18) | 0.0647 (11) | |
H2A | 0.4235 | 1.4745 | 0.0285 | 0.078* | |
H2B | 0.3648 | 1.4879 | 0.0829 | 0.078* | |
H2C | 0.2535 | 1.5009 | 0.0299 | 0.078* | |
C3 | 0.3229 (4) | 1.2427 (5) | 0.04738 (14) | 0.0484 (9) | |
C4 | 0.2029 (4) | 1.1649 (5) | 0.07455 (14) | 0.0468 (9) | |
H4 | 0.1122 | 1.2357 | 0.0635 | 0.056* | |
C5 | 0.2445 (4) | 1.1841 (5) | 0.13463 (14) | 0.0455 (8) | |
C6 | 0.1792 (4) | 1.3210 (5) | 0.16146 (14) | 0.0494 (9) | |
H6 | 0.1089 | 1.3986 | 0.1430 | 0.059* | |
C7 | 0.2189 (4) | 1.3412 (5) | 0.21547 (15) | 0.0509 (9) | |
C8 | 0.3220 (4) | 1.2242 (6) | 0.24348 (14) | 0.0524 (9) | |
C9 | 0.3886 (5) | 1.0923 (6) | 0.21735 (16) | 0.0643 (11) | |
H9 | 0.4591 | 1.0148 | 0.2358 | 0.077* | |
C10 | 0.3494 (5) | 1.0753 (6) | 0.16247 (17) | 0.0619 (11) | |
H10 | 0.3963 | 0.9873 | 0.1446 | 0.074* | |
C11 | 0.0659 (8) | 1.6037 (9) | 0.2184 (2) | 0.113 (2) | |
H11A | 0.0337 | 1.6854 | 0.2438 | 0.135* | |
H11B | −0.0188 | 1.5445 | 0.1986 | 0.135* | |
H11C | 0.1177 | 1.6715 | 0.1947 | 0.135* | |
C12 | 0.4408 (7) | 1.1231 (8) | 0.32818 (19) | 0.0921 (17) | |
H12C | 0.5407 | 1.1325 | 0.3207 | 0.110* | |
H12B | 0.4039 | 1.0021 | 0.3198 | 0.110* | |
H12A | 0.4397 | 1.1471 | 0.3650 | 0.110* | |
C13 | −0.2032 (5) | 0.9993 (7) | 0.1135 (2) | 0.0775 (14) | |
H13A | −0.1927 | 0.9192 | 0.1441 | 0.093* | |
H13B | −0.2758 | 0.9466 | 0.0860 | 0.093* | |
C14 | −0.2513 (6) | 1.1834 (9) | 0.1279 (3) | 0.107 (2) | |
H14A | −0.2610 | 1.2613 | 0.0974 | 0.128* | |
H14B | −0.1789 | 1.2337 | 0.1552 | 0.128* | |
H14C | −0.3452 | 1.1745 | 0.1404 | 0.128* | |
N1 | 0.4023 (4) | 1.1293 (5) | 0.02587 (13) | 0.0568 (9) | |
O1 | 0.5120 (4) | 1.2189 (4) | 0.00144 (14) | 0.0753 (10) | |
H1 | 0.558 (6) | 1.113 (8) | −0.0050 (19) | 0.090* | |
O2 | −0.0617 (3) | 1.0207 (4) | 0.09477 (11) | 0.0606 (8) | |
O3 | 0.1610 (4) | 1.4719 (5) | 0.24482 (11) | 0.0753 (9) | |
O4 | 0.3500 (3) | 1.2518 (4) | 0.29732 (11) | 0.0696 (8) | |
S1 | −0.06609 (14) | 0.67062 (17) | 0.06848 (5) | 0.0759 (4) | |
S2 | 0.16706 (11) | 0.92796 (14) | 0.05342 (4) | 0.0576 (4) | |
Atomic displacement parameters (Å2) top | U11 | U22 | U33 | U12 | U13 | U23 |
C1 | 0.057 (2) | 0.055 (2) | 0.045 (2) | −0.0034 (19) | 0.0096 (16) | 0.0060 (18) |
C2 | 0.082 (3) | 0.049 (2) | 0.069 (3) | −0.001 (2) | 0.032 (2) | −0.006 (2) |
C3 | 0.055 (2) | 0.046 (2) | 0.0460 (19) | −0.0016 (18) | 0.0154 (16) | −0.0014 (16) |
C4 | 0.056 (2) | 0.042 (2) | 0.0464 (19) | −0.0010 (17) | 0.0197 (16) | −0.0024 (16) |
C5 | 0.0499 (18) | 0.040 (2) | 0.051 (2) | 0.0018 (17) | 0.0212 (15) | −0.0030 (16) |
C6 | 0.0524 (19) | 0.047 (2) | 0.052 (2) | 0.0091 (17) | 0.0173 (16) | 0.0034 (17) |
C7 | 0.057 (2) | 0.047 (2) | 0.053 (2) | 0.0045 (18) | 0.0215 (17) | −0.0044 (17) |
C8 | 0.060 (2) | 0.053 (2) | 0.046 (2) | 0.0010 (19) | 0.0160 (17) | 0.0059 (17) |
C9 | 0.068 (2) | 0.067 (3) | 0.060 (3) | 0.017 (2) | 0.013 (2) | 0.011 (2) |
C10 | 0.070 (2) | 0.054 (3) | 0.065 (3) | 0.020 (2) | 0.023 (2) | 0.001 (2) |
C11 | 0.141 (5) | 0.115 (5) | 0.079 (4) | 0.078 (4) | 0.009 (3) | −0.026 (3) |
C12 | 0.128 (5) | 0.079 (4) | 0.064 (3) | 0.020 (4) | −0.002 (3) | 0.013 (3) |
C13 | 0.064 (3) | 0.097 (4) | 0.079 (3) | −0.013 (3) | 0.035 (2) | −0.008 (3) |
C14 | 0.077 (3) | 0.121 (5) | 0.130 (5) | 0.005 (4) | 0.042 (3) | −0.023 (4) |
N1 | 0.0624 (19) | 0.050 (2) | 0.066 (2) | 0.0010 (16) | 0.0365 (16) | 0.0082 (16) |
O1 | 0.085 (2) | 0.0531 (18) | 0.102 (2) | −0.0042 (16) | 0.0606 (18) | 0.0027 (17) |
O2 | 0.0580 (15) | 0.0671 (19) | 0.0624 (17) | −0.0074 (14) | 0.0272 (13) | −0.0030 (14) |
O3 | 0.097 (2) | 0.079 (2) | 0.0514 (16) | 0.0354 (18) | 0.0134 (15) | −0.0110 (15) |
O4 | 0.086 (2) | 0.073 (2) | 0.0508 (16) | 0.0123 (17) | 0.0118 (14) | 0.0061 (14) |
S1 | 0.0790 (8) | 0.0609 (8) | 0.0857 (9) | −0.0157 (6) | 0.0057 (6) | 0.0069 (6) |
S2 | 0.0633 (6) | 0.0487 (6) | 0.0655 (7) | −0.0025 (5) | 0.0253 (5) | −0.0077 (5) |
Geometric parameters (Å, º) top
C1—O2 | 1.309 (5) | C9—C10 | 1.401 (6) |
C1—S1 | 1.639 (4) | C9—H9 | 0.9300 |
C1—S2 | 1.741 (4) | C10—H10 | 0.9300 |
C2—C3 | 1.488 (5) | C11—O3 | 1.400 (6) |
C2—H2A | 0.9600 | C11—H11A | 0.9600 |
C2—H2B | 0.9600 | C11—H11B | 0.9600 |
C2—H2C | 0.9600 | C11—H11C | 0.9600 |
C3—N1 | 1.278 (5) | C12—O4 | 1.414 (6) |
C3—C4 | 1.494 (5) | C12—H12C | 0.9600 |
C4—C5 | 1.533 (5) | C12—H12B | 0.9600 |
C4—S2 | 1.831 (4) | C12—H12A | 0.9600 |
C4—H4 | 0.9800 | C13—O2 | 1.451 (5) |
C5—C10 | 1.360 (5) | C13—C14 | 1.480 (7) |
C5—C6 | 1.397 (5) | C13—H13A | 0.9700 |
C6—C7 | 1.382 (5) | C13—H13B | 0.9700 |
C6—H6 | 0.9300 | C14—H14A | 0.9600 |
C7—C8 | 1.388 (5) | C14—H14B | 0.9600 |
C7—O3 | 1.370 (4) | C14—H14C | 0.9600 |
C8—C9 | 1.368 (6) | N1—O1 | 1.417 (4) |
C8—O4 | 1.377 (5) | O1—H1 | 0.91 (6) |
| | | |
O2—C1—S1 | 127.5 (3) | C5—C10—C9 | 121.7 (4) |
O2—C1—S2 | 113.9 (3) | C5—C10—H10 | 119.1 |
S1—C1—S2 | 118.7 (2) | C9—C10—H10 | 119.1 |
C3—C2—H2A | 109.5 | O3—C11—H11A | 109.5 |
C3—C2—H2B | 109.5 | O3—C11—H11B | 109.5 |
H2A—C2—H2B | 109.5 | H11A—C11—H11B | 109.5 |
C3—C2—H2C | 109.5 | O3—C11—H11C | 109.5 |
H2A—C2—H2C | 109.5 | H11A—C11—H11C | 109.5 |
H2B—C2—H2C | 109.5 | H11B—C11—H11C | 109.5 |
N1—C3—C2 | 124.4 (3) | O4—C12—H12C | 109.5 |
N1—C3—C4 | 117.0 (3) | O4—C12—H12B | 109.5 |
C2—C3—C4 | 118.6 (3) | H12C—C12—H12B | 109.5 |
C3—C4—C5 | 110.1 (3) | O4—C12—H12A | 109.5 |
C3—C4—S2 | 109.5 (2) | H12C—C12—H12A | 109.5 |
C5—C4—S2 | 112.9 (3) | H12B—C12—H12A | 109.5 |
C3—C4—H4 | 108.1 | O2—C13—C14 | 107.2 (4) |
C5—C4—H4 | 108.1 | O2—C13—H13A | 110.3 |
S2—C4—H4 | 108.1 | C14—C13—H13A | 110.3 |
C10—C5—C6 | 118.7 (3) | O2—C13—H13B | 110.3 |
C10—C5—C4 | 121.3 (3) | C14—C13—H13B | 110.3 |
C6—C5—C4 | 119.9 (3) | H13A—C13—H13B | 108.5 |
C5—C6—C7 | 120.0 (3) | C13—C14—H14A | 109.5 |
C5—C6—H6 | 120.0 | C13—C14—H14B | 109.5 |
C7—C6—H6 | 120.0 | H14A—C14—H14B | 109.5 |
C8—C7—O3 | 115.8 (3) | C13—C14—H14C | 109.5 |
C8—C7—C6 | 120.3 (3) | H14A—C14—H14C | 109.5 |
O3—C7—C6 | 123.9 (3) | H14B—C14—H14C | 109.5 |
C9—C8—C7 | 120.0 (4) | C3—N1—O1 | 111.8 (3) |
C9—C8—O4 | 124.3 (4) | N1—O1—H1 | 93 (3) |
C7—C8—O4 | 115.8 (3) | C1—O2—C13 | 119.4 (3) |
C8—C9—C10 | 119.1 (4) | C7—O3—C11 | 118.6 (3) |
C8—C9—H9 | 120.4 | C8—O4—C12 | 117.7 (3) |
C10—C9—H9 | 120.4 | C1—S2—C4 | 103.05 (18) |
| | | |
N1—C3—C4—C5 | 108.4 (4) | O4—C8—C9—C10 | 179.0 (4) |
C2—C3—C4—C5 | −71.4 (5) | C6—C5—C10—C9 | 2.6 (6) |
N1—C3—C4—S2 | −16.3 (4) | C4—C5—C10—C9 | 179.7 (4) |
C2—C3—C4—S2 | 164.0 (3) | C8—C9—C10—C5 | −1.4 (7) |
C3—C4—C5—C10 | −74.3 (4) | C2—C3—N1—O1 | −0.2 (6) |
S2—C4—C5—C10 | 48.4 (4) | C4—C3—N1—O1 | −180.0 (3) |
C3—C4—C5—C6 | 102.8 (4) | S1—C1—O2—C13 | −0.3 (5) |
S2—C4—C5—C6 | −134.5 (3) | S2—C1—O2—C13 | 179.1 (3) |
C10—C5—C6—C7 | −1.5 (6) | C14—C13—O2—C1 | −174.0 (4) |
C4—C5—C6—C7 | −178.6 (3) | C8—C7—O3—C11 | 174.7 (5) |
C5—C6—C7—C8 | −1.0 (6) | C6—C7—O3—C11 | −6.0 (7) |
C5—C6—C7—O3 | 179.7 (4) | C9—C8—O4—C12 | −7.4 (6) |
O3—C7—C8—C9 | −178.3 (4) | C7—C8—O4—C12 | 172.8 (4) |
C6—C7—C8—C9 | 2.3 (6) | O2—C1—S2—C4 | 6.1 (3) |
O3—C7—C8—O4 | 1.5 (5) | S1—C1—S2—C4 | −174.5 (2) |
C6—C7—C8—O4 | −177.8 (3) | C3—C4—S2—C1 | −165.9 (3) |
C7—C8—C9—C10 | −1.1 (6) | C5—C4—S2—C1 | 71.1 (3) |
Hydrogen-bond geometry (Å, º) top
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1···N1i | 0.91 (6) | 1.90 (6) | 2.786 (5) | 164 (5) |
Symmetry code: (i) −x+1, −y+2, −z. |
Experimental details
Crystal data |
Chemical formula | C14H19NO4S2 |
Mr | 329.42 |
Crystal system, space group | Monoclinic, P21/c |
Temperature (K) | 299 |
a, b, c (Å) | 9.114 (2), 7.319 (2), 25.575 (6) |
β (°) | 98.66 (2) |
V (Å3) | 1686.5 (7) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.33 |
Crystal size (mm) | 0.66 × 0.60 × 0.24 |
|
Data collection |
Diffractometer | Oxford Diffraction Xcalibur CCD diffractometer |
Absorption correction | – |
No. of measured, independent and observed [I > 2σ(I)] reflections | 4733, 3161, 1809 |
Rint | 0.047 |
(sin θ/λ)max (Å−1) | 0.625 |
|
Refinement |
R[F2 > 2σ(F2)], wR(F2), S | 0.071, 0.220, 0.93 |
No. of reflections | 3161 |
No. of parameters | 193 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.40, −0.42 |
Selected geometric parameters (Å, º) topC1—O2 | 1.309 (5) | C4—S2 | 1.831 (4) |
C1—S1 | 1.639 (4) | C7—O3 | 1.370 (4) |
C1—S2 | 1.741 (4) | C8—O4 | 1.377 (5) |
C3—N1 | 1.278 (5) | N1—O1 | 1.417 (4) |
| | | |
O2—C1—S1 | 127.5 (3) | C3—C4—C5 | 110.1 (3) |
O2—C1—S2 | 113.9 (3) | C3—C4—S2 | 109.5 (2) |
S1—C1—S2 | 118.7 (2) | C5—C4—S2 | 112.9 (3) |
N1—C3—C2 | 124.4 (3) | C3—N1—O1 | 111.8 (3) |
N1—C3—C4 | 117.0 (3) | N1—O1—H1 | 93 (3) |
C2—C3—C4 | 118.6 (3) | | |
| | | |
C2—C3—N1—O1 | −0.2 (6) | C8—C7—O3—C11 | 174.7 (5) |
C4—C3—N1—O1 | −180.0 (3) | C7—C8—O4—C12 | 172.8 (4) |
Hydrogen-bond geometry (Å, º) top
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1···N1i | 0.91 (6) | 1.90 (6) | 2.786 (5) | 164 (5) |
Symmetry code: (i) −x+1, −y+2, −z. |
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The title compound, (I), is the starting material for the synthesis of N-hydroxy-5-(3,4-dimethoxyphenyl)-4-methylthiazole-2(3H)-thione, a molecule of notable interest for investigating substituent effects on the location of absorption bands caused by visible to near-UV light excitations in heterocyclic alkoxyl radical precursors (Hartung, Špehar et al., 2005). Compound (I) has been crystallized and studied by X-ray diffraction in order to gain an understanding of its structural details in the solid state.
The stereogenic centre, atom C4, is substituted by three virtually planar groups, viz a 3,4-dimethoxyphenyl, an O-ethyl dithiocarbonate and an ethyloximino group, and by one H atom (Fig. 1). The heteroatoms and the central C atom of the dithiocarbonate group are located in a plane [deviation of O2 = 0.012 (1) Å]. The stereogenic bonds associated with the latter entity adopt an (E) arrangement for C1—S2 and (Z) geometry for C1—O2. The C1—S1 distance [1.639 (4) Å] is smaller than the mean value for the C═S double bond in O,S-dialkyldithiocarbonates [1.67 (2) Å; Abrahamson & Innes, 1974; Allen et al., 1987; Duarte et al., 1989]. The connectivities S2—C1 and S2—C4 differ in length due to different hybridization of the associated C atoms (Zhang et al., 2003, Hartung, Schmidt et al., 2005). The oxime group adopts an (E) configuration. The distances N1—O1 and N1═C3 distances agree with mean values for both types of connectivities (Allen et al., 1987; Hartung et al., 2004).
The unit cell (Z = 4) comprises a 1:1 mixture of (S) and (R) enantiomers. A view along 001 indicates that these enantiomers are linked via a tandem hydrogen bond to provide dimers. The oxime H atom serves as the donor toward the oxime N atom of an adjacent molecule (Fig. 2, Table 2).