crystallization communications
The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4+ T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 α-I (PQPELPYPQ) and DQ8 α-I (EGSFQPSQE), respectively, are reported.
Supporting information
Portable Document Format (PDF) file https://doi.org/10.1107/S1744309107051408/en5259sup1.pdf | |
Portable Document Format (PDF) file https://doi.org/10.1107/S1744309107051408/en5259sup2.pdf |