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The sequence d(TGCGCG)·d(CGCGCA) crystallized in two crystal forms, orthorhombic and hexagonal, in the presence of cobalt hexammine chloride, a known inducer of the left-handed Z-form of DNA. The crystal structures have been solved and refined at 1.71 Å resolution in space group P212121 and 2.0 Å resolution in space group P65. The orthorhombic structure contains one Z-DNA hexamer duplex, while the hexagonal structure contains two hexamer duplexes in the structure. Of the latter, one is situated on a crystallographic sixfold screw axis, leading to disorder. This paper reports the effects of sequence and crystal packing on the structure of Z-­type DNA. The structures lend additional support to the authors' earlier conclusion that a stretch of four C·G base pairs is sufficient to nucleate and define the regular model of the left-handed helix based on the structure of d(CGCGCG)2.

Supporting information

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Portable Document Format (PDF) file https://doi.org/10.1107/S0907444905016781/dz5045sup1.pdf
Supplementary material

NDB references: ZD0013; ZD0014


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