structural genomics papers
Crystal structures are reported for free and coenzyme A (CoA) bound forms of the YfdW protein from Escherichia coli, a representative type III CoA transferase. The structures reveal a two-domain protomer with interdomain connections forming a ring-like structure with a large central hole. Two protomers associate to form a highly intertwined dimer in which the hole of each ring is filled by the partner molecule. Each protomer binds a single CoA molecule and these CoA-binding sites are distant from one another in the dimer.
Supporting information
PDB references: YfdW at 2.35 Å resolution, 1pqy, r1pqysf; YfdW at 1.6 Å resolution, 1q7e, r1q7esf; YfdW–CoA complex, 1q6y, r1q6ysf