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The crystal structures of 2',3'-dideoxy-3'-nitrothymidine, C10H13N3O6 and 2'-propoxy-3'-nitrothymidine, C13H19N3O7, are reported. Both compounds are analogous to the anti-HIV nucleoside 3'-azido-2',3'-dideoxythymidine (AZT). The replacement of the azido group in AZT by the nitro group in these two compounds has resulted in a sugar pucker preference of C2'-endo type, as observed in both structures, AZT itself and several of its derivatives.

Supporting information

cif

Crystallographic Information File (CIF)
Contains datablocks I, II, global

CCDC references: 128331; 128332

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