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organic compounds
In the title compound, methyl (22S)-11β-hydroxy-16α,17α-[(methoxy)(methyl)methylenedioxypregna-1,4-diene-3,20-dione-21-acetate, C26H34O8, part of the orthoacetate group forms the dioxalane ring (E) fused with the steroid skeleton at the C16 and C17 atoms. Ring A is planar, rings B and C adopt chair conformations, while rings D and E have conformations midway between half-chair and envelope. Intermolecular O11—H
O3 hydrogen bonds are formed. The new chiral center at atom C22 of the dioxolane ring has an S configuration and the conformation of the ring, closed at C22, is comparable with the conformations found for the (22R) diastereoisomers of similar compounds.
O3 hydrogen bonds are formed. The new chiral center at atom C22 of the dioxolane ring has an S configuration and the conformation of the ring, closed at C22, is comparable with the conformations found for the (22R) diastereoisomers of similar compounds.
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