3-(m-Bromophenyl)-1-(3-methyl-2-pyridyl)pyrrolidin-2,5-dione

The title compound C₁₆H₁₃BrN₂O₂ is one of the 27 phenylsuccinimides for which the correlation between structure and anticonvulsant activity was examined in an earlier study. All of the possible minimum-energy conformations for all of the compounds were found using molecular modelling. For eight of the 27 derivatives the X-ray structures were determined and these were used as a guide to find the correct conformations among the minimum-energy conformations derived from calculations. The results of the present study show that the title compound also has a conformation similar to that calculated previously which confirms that the correct conformation was selected to calculate the structure-activity correlations.

-1