Spirapril Hydrochloride Hydrate

The crystal structure of the monohydrate form of spirapril hydrochloride, (8S-{7[R*(R*)],8R*})-7-(2-{[1-(ethoxycarbonyl)-3-phenylpropyl]amino}-1- oxopropyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid hydrochloride, C₂₂H₃₁N₂O₅S₂⁺.Cl^-.H₂O, was determined. The spirapril molecules adopt a trans conformation along the amide bond. The incorporated water molecules form hydrogen bonds with the host molecules.

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