Journal of Synchrotron Radiation

Volume 15, Part 3 (May 2008)

diffraction structural biology

J. Synchrotron Rad. (2008). 15, 215-218 [ doi:10.1107/S0909049508000824 ]

Protein structures by spallation neutron crystallography

P. Langan, Z. Fisher, A. Kovalevsky, M. Mustyakimov, A. Sutcliffe Valone, C. Unkefer, M. J. Waltman, L. Coates, P. D. Adams, P. V. Afonine, B. Bennett, C. Dealwis and B. P. Schoenborn

Abstract: The Protein Crystallography Station at Los Alamos Neutron Science Center is a high-performance beamline that forms the core of a capability for neutron macromolecular structure and function determination. This capability also includes the Macromolecular Neutron Crystallography (MNC) consortium between Los Alamos (LANL) and Lawrence Berkeley National Laboratories for developing computational tools for neutron protein crystallography, a biological deuteration laboratory, the National Stable Isotope Production Facility, and an MNC drug design consortium between LANL and Case Western Reserve University.

Keywords: neutrons; proteins; macromolecular crystallography; deuteration; enzyme mechanisms; drug binding; hydration; joint XN structure refinement.

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