J. Synchrotron Rad. (2003). 10, 96-102 [ doi:10.1107/S0909049502017259 ]
Abstract: X-ray absorption spectroscopy provides valuable information on metallic speciation and so has a wide range of applications in bioinorganic systems. In this paper, low-molar-mass metallic complexes as used in pharmaceutical science are focused on. The results of structural studies on metal-based drugs applied as disease treatments, nutritional supplements or tools for diagnostic methods are presented. Then metal speciation (spatial and chemical distribution) in biological samples through micro-XANES imaging experiments are dealt with. Problems arising from the analysis of noisy data collected from these diluted samples are discussed.
Keywords: X-ray absorption near-edge structure (XANES); X-ray absorption spectroscopy; biological speciation; pharmaceutical science; metal-based drugs.
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