Acta Crystallographica Section B

Structural Science

Volume 56, Part 4 (August 2000)


research papers



Acta Cryst. (2000). B56, 715-719    [ doi:10.1107/S0108768100002172 ]

Non-centrosymmetric racemates: space-group frequencies and conformational similarities between crystallographically independent molecules

B. Dalhus and C. H. Görbitz

Abstract: DL-Allylglycine (DL-2-amino-4-pentenoic acid, C5H9NO2) yields crystals with Pca21 symmetry and two crystallographically independent yet pseudo-inversion-related enantiomers. The distribution among the common space groups of other crystalline racemates with more than one molecule in the asymmetric unit has been established. The conformational similarities between crystallographically independent enantiomers in 114 non-centrosymmetric racemates were quantified using the r.m.s. deviation for a molecular superposition. The analysis shows that in the majority of crystals the conformations of the crystallographically independent molecules are very similar with mean r.m.s. deviation = 0.190 Å. In almost 80% of the structures the mean r.m.s. deviations is in the interval 0-0.2 Å. It is estimated that racemates constitute 23% of the centrosymmetric organic structures in the Cambridge Structural Database.

Keywords: Non-centrosymmetric racemates; Space-group frequencies; Conformation; DL-Allylglycine.

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